Failed Tamoxifen & chemo metastatic now ! need your experience

Havefaith79

I have mucinous breast cancer stage IIb, had no chemo because the doctors thought that mucinous type doesn't respond to chemotherapy and they convinced me that my best treatment is Tamoxifen since my tumourbwas progesterone and estrogen positive

So i was on Tamoxifen for 3years and mamo has vern always clear and clean

Until Last November i found a lump in my thyroid which turned to be benign,i was so happy however another doctor suggested ct scan for neck and chest , by May 2016 i did all the required scans and analysis which showed multiple cancerous nodules in my mediastinal and both lungs Plus a number of lymph nodes (diagnosed with metastatic mucinous breast cancer )

I changed the oncologist and he recommended 6 cycles of chemo ! After 3 cycles ct sac shied progression of the tumours so he decided to stop chemo and go back to hormonal therapy

He put me now on Zoladex injunction once a month/ daily tablet of 25 mg of Aromasin / daily tablet of 30 mg of everolimus This sounds to my last option of treatment, I'm so scared what if it didn't work either

Bestbird

I am sorry to hear your initial treatments didn't work as well as hoped, but you have many more options to try! Hormonal treatment depends on your menopausal status, which I am assuming is pre-menopausal.

Whenever a patient is faced with changing a treatment, it is helpful to seek a second opinion.

Below from my MBC Guide is a list of possible therapies for premenopausal mbc. You (and others) are welcome to request a complimentary copy of the 120+ page booklet by visiting: https://community.breastcancer.org/forum/8/topics/831507?page=2#idx_32

In general, the sequence of providing hormonal therapy for premenopausal women is as follows:

• Upon diagnosis, Tamoxifen along with a Luteinizing Hormone-Releasing Hormone (LHRH) agonist such as Zoladex or Lupron are recommended.(LHRH agonists work by telling the pituitary gland located in the brain to stop producing luteinizing hormone, which in women stimulates the ovaries to release estrogen. The drug does not have a direct effect on breast cancer, only on the ovaries. The resulting lack of estrogen interferes with stimulating cell growth in estrogen dependent cancer cells).
• After progression (when the cancer has begun to grow again despite treatment), ovarian ablation (removal of the ovaries, called "oopherectomy") is appropriate as second-line therapy because it removes a substantial source of estrogen from being produced by the body. The good news is that women who have undergone ovarian ablation may then begin to take advantage of hormonal therapies that are available to postmenopausal women such as Femara (Letrozole), Arimidex (Anastrozole), Exemestane (Aromasin) and possibly Faslodex.

Kandy

So sorry you are joining this group. I hope your new treatment works well. Like Bestbird said, there are lots of options for you. Wishing you the best

Havefaith79

Thanks for kindnessBestbird,, kandy