Clinical trails for metastatic HER2+ PIK3CA

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fight2s
fight2s Member Posts: 5

Hi,
My mom is taking treatment for HER2+ ER-/PR-. I have collected some of the clinical trails which are specific to HER2+ ER-/PR- condition as listed below. If anyone has more info, please do add to the list below.

After finding these many trails I got more confused on how to select a better suited one.
I'm in India and am preparing to take my mom to US but would like to finalize the trail before I come there due to logistical reasons (many of the trails are available at some hospitals only). Please share if anyone has information on if there is a way to consult experts in HER2+ breast cancer who can guide me make that decision before coming to US .

Phase 3

Neratinib Plus Capecitabine https://clinicaltrials.gov/ct2/show/study/NCT01808...

Phase 2
Targeted
Lapatinib, Everolimus and Capecitabine https://clinicaltrials.gov/ct2/show/NCT01783756
Poziotinib https://clinicaltrials.gov/ct2/show/NCT02659514
ONT-380 with Capecitabine & Trastuzumab https://clinicaltrials.gov/ct2/show/study/NCT02614...
Everolimus, Trastuzumab And Vinorelbine https://clinicaltrials.gov/ct2/show/NCT01305941
Ribociclib with TDM1 https://clinicaltrials.gov/ct2/show/NCT02657343
Neratinib https://clinicaltrials.gov/ct2/show/study/NCT01953...
Palbociclib with TDM1 https://clinicaltrials.gov/ct2/show/NCT01976169
Enzalutamide With Trastuzumab https://clinicaltrials.gov/ct2/show/study/NCT02091...
Eribulin Mesylate, Trastuzumab, and Pertuzumab https://clinicaltrials.gov/ct2/show/NCT01912963
Gemcitabine, Trastuzumab, and Pertuzumab https://clinicaltrials.gov/ct2/show/NCT02252887
https://clinicaltrials.gov/ct2/show/NCT02139358
Cabozantinib With Trastuzumab https://clinicaltrials.gov/ct2/show/NCT02260531
PD 0332991 https://clinicaltrials.gov/ct2/show/NCT01037790
PIK3CA
Albumin-Bound Rapamycin https://clinicaltrials.gov/ct2/show/NCT02646319
BGJ398/BYL719 https://clinicaltrials.gov/ct2/show/NCT01928459
https://clinicaltrials.gov/ct2/show/NCT02038010
LJM716, BYL719 and Trastuzumab https://clinicaltrials.gov/ct2/show/NCT02167854
PM01183 https://clinicaltrials.gov/ct2/show/NCT01525589
Taselisib https://clinicaltrials.gov/ct2/show/NCT02390427
Immunotherapy
Pembrolizumab + TDM1 https://clinicaltrials.gov/ct2/show/NCT02318901

Phase 1
PIK3CA
Temsirolimus With Metformin https://clinicaltrials.gov/ct2/show/NCT01529593
BKM120 or BYL719 https://clinicaltrials.gov/ct2/show/study/NCT01300...
AZD5363 https://clinicaltrials.gov/ct2/show/NCT01226316
Targeted
Ruxolitinib With Trastuzumab https://clinicaltrials.gov/ct2/show/NCT02066532
TDM1 With Abraxane and Lapatinib https://clinicaltrials.gov/ct2/show/NCT02073916
T-DM1 With Neratinib https://clinicaltrials.gov/ct2/show/NCT02236000
Ganetespib, Paclitaxel, Trastuzumab and Pertuzumab https://clinicaltrials.gov/ct2/show/NCT02060253
Pyrotinib https://clinicaltrials.gov/ct2/show/NCT02500199 FS102 https://clinicaltrials.gov/ct2/show/NCT02286219
Vorinostat With Paclitaxel and Carboplatin https://clinicaltrials.gov/ct2/show/NCT01249443 MEDI4276 https://clinicaltrials.gov/ct2/show/NCT02576548 https://clinicaltrials.gov/ct2/show/NCT01421524 BAY1125976 https://clinicaltrials.gov/ct2/show/NCT01915576
Ribocilcib (LEE011) https://clinicaltrials.gov/ct2/show/NCT02599363
Immunotherapy
Autologous Dendritic Cells Loaded With Oncofetal Antigen/iLRP https://clinicaltrials.gov/ct2/show/NCT00715832 https://clinicaltrials.gov/ct2/show/NCT02479230 https://clinicaltrials.gov/ct2/show/NCT01376505 https://clinicaltrials.gov/ct2/show/NCT02048709
TAA-Specific CTLS https://clinicaltrials.gov/ct2/show/NCT02239861 https://clinicaltrials.gov/ct2/show/NCT02276300
AVX901 https://clinicaltrials.gov/ct2/show/NCT01526473


Thanks

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