Researchers discover a mechanism that reverses resistance....

cp418

https://www.sciencedaily.com/releases/2016/06/1606...

Researchers discover a mechanism that reverses resistance to antiangiogenic drugs

Antiangiogenics like TKIs are one of the most widely used cancer treatments but patients eventually develop resistance. Adding an antidiabetic to the drug regimen eliminates resistance to TKIs and inhibits tumor growth up to 92 percent in animal models

Fallleaves

This is very interesting. I wonder why they didn't use metformin, though? From this article it seems like metformin has fewer side effects: http://www.nature.com/nrendo/journal/v10/n3/fig_ta...

Also, phenformin is metabolized via CYP2D6, which raises the same issues as with tamoxifen, some people don't metabolize it well.