Splitting Tamoxifen Tablet - IMPORTANT INFO!!!!!

SugarCane

I asked my oncologist about halving tamoxifen (1/2 in am, 1/2 in pm) because it really helped with my side effects (advice I got from some sweet ladies here His nurse called the manufacturer and they said DO NOT break the tablet. They said tamoxifen loses its effectiveness by splitting the tablet. I didn't get an explanation as to why this happens, but they said it does. I felt this was too important not to share. ❤️

Marietje

Potential Consequences of Splitting, Crushing and Opening

Crushing products with carcinogenic (e.g. tamoxifen; methotrexate) or teratogenic (e.g. valganciclovir) potential may expose carers or healthcare professionals to health risks through powder aerosolisation and as such should not be undertaken. Similarly, preparations containing hormones (oral contraceptives; hormonal replacement therapy), corticosteroids (such as dexamethasone) and some other drugs (finasteride; mycophenolate) should not be crushed due to the risks associated with powder aerosolisation.3-6 It should be noted that the effects of many other drugs when inhaled are largely unknown.

In addition several drug substances may also cause irritation if the powder is aerosolised and inhaled or comes into contact with the eyes, skin, or other mucous membranes e.g. alendronate, diflunisal, isotretinoin, piroxicam. Ganciclovir is known to be a skin irritant, and exposing the skin to hydroxycarbamide powder can cause serious skin toxicity.

coraleliz

Tamoxifen comes in 10mg strength. Or it use to. Ask your MO to order it that way.

rodeogirl

my boyfriend took 4 of them in one hit did nothing lol

Bounce

Why would he take 4 Tamoxifen?