HERCEPTIN AND TYKERB FOR HER2+ HORMONE POS.

momallthetime

Hi everyone, I actually do the legwork for my daughter. She is 31 with MBC for awhile already. i will try to make this short. She has been on just about all tx already.!!

Now Onco wants to try HERCEPTIN/TYKERB along with Ibrance/Letrozole she is already taking. I will give you some info.

Last year after very aggressive progression and after much nagging the Onco, she finally had a rebiopsy from the original DX, and voila, it showed that HER2 status changed from HER2- to HER2+ fish +++ . Biopsy sent to F1, and of course it showed she SHOULD be good for all the good stuff afforded to HER2+ (but it failed her, Herceptin/Perjeta/ TDM1 all for naught). Original DX: ER+PR+HER2- changed to ER+PR+HER2+

She has extensive bone mets, all throughout her skeleton including more than 20 lesions to the skull. She had GammaKnife done last year, for some lesions really pushing into the Dura, (it got a bit smaller). The last few days she has had numbing and tingling on partial side of face, she had a facial MRI but it did not show any nerves being pressed so we are on wait and see.

Changed Onco, this year he put her on Ibrance/Letrozole for 3 cycles, just did scans 2 wks ago, crazy report, it read like a comic book, some stability, some clearing of some lesions that have been there for a long awhile, and some NEW lesions!. So after much back and forth, he decided he will put her back on Herceptin/Perjeta with Ibrance/Letrozole. At first I could not understand altogether about IBR/Letr with someone with Her2+ , but I've come to learn from the wonderful ladies in a different thread here, that there are many Pathways to Her2 and they are targeting IT with different target therapies.

Well, Perjeta for unknown reason to us, was rejected by Insurance. Herceptin was confirmed. So now Onco prescribed Herceptin and TYKERB for her to take along with Ibrance/Letrozole.

So ladies, could I ask you about this mixture? What say you? At least about the Herceptin/Tykerb. We would love to hear what your experience with these are. Also, What strength are you taking TYKERB, all 1000 a day?

Thanks so much for any info you guys could offer