Anyone else a carrier of X-linked Ichthyosis?

grandma3X

I posted this on the hormone therapy thread but thought this may be a better place for it. Sorry for the cross-posting

X-linked ichthyosis is a genetic disorder. It's a mutation or (more likely) a deletion of the gene for steroid sulfatase (STS). This gene is present on the X-chromosome so may be passed from the mother to her children. Boys who inherit this gene usually have very dry scaly skin, while girls typically have no symptoms, since they have the normal gene on their other X-chromosome to compensate for the defective one. However, women who are carriers of the gene do have reduced STS activity - anywhere from 70-98% less STS activity than women who don't carry this gene.

Why is this interesting? Because STS is involved in production of estrogen and there has been an interest in developing dual inhibitors that inhibit both aromatase and STS. I'm curious if there has ever been a study of ER+ breast cancer in patients who are carriers of X-linked ichthyosis. It seems to me that X-linked ichthyosis may confer added protection to women who are on aromatase inhibitors.

If you are a carrier of X-linked ichthyosis and are on AI, or if you know of any studies on the relationship between X-linked ichthyosis and ER+ breast cancer, I'd love it if you would post a comment here. Thanks!