dendrogenin A and tamoxifen

Lojo

Found this in ScienceDaily today - - not a very well-written summary, but I thought I'd post in case anyone can make something out of it.

http://www.sciencedaily.com/releases/2016/01/16011...

Link to abstract: http://www.eurekaselect.com/133292/article

From ScienceDaily:

"These researchers recently identified an enzyme involved in cholesterol metabolism as a target of the antitumor drug, Tamoxifen: the cholesterol-5,6-epoxide hydrolase. They postulated that a new metabolic pathway could exist from the metabolic transformation 5,6α-epoxycholesterol (5,6α-EC), a natural oxidation product of cholesterol. A conjugation product of 5,6α-EC with histamine was synthesized to give DDA. DDA showed a strong potency to induce cell differentiation activity at low dose suggesting its possible existence as an endogenous metabolite. This was next established by these researchers and they found that DDA levels were strongly decreased in tumors suggesting a deregulation in DDA metabolism in cancers. "