BC study suggests new potential drug targets and combinations

cp418

http://medicalxpress.com/news/2016-01-breast-cance...

Breast cancer study suggests new potential drug targets and combinations

JohnSmith

This is interesting, though very technical.

The details of the study, referenced in the article, can be found here:
"Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance"

Highlights
- We screened 77 breast cancer cell lines using a genome-wide pooled shRNA library
- We developed an algorithm (siMEM) to improve identification of context-dependent genes
- Integrating screen results with genomic data reveals potential "drivers"
- BRD4 is essential for luminal cancer, and mutant PIK3CA confers BET-I resistance