TapImmune Phase 2 Vaccine Trial - Mayo Clinic

TectonicShift

Saw this just today on the Yahoo Finance page:

http://finance.yahoo.com/news/tapimmunes-phase-ii-...

I would assume (hope) this phase 2 vaccine trial will be enrolling at all three Mayo locations, Arizona, Florida, and Minnesota.

excerpt:

Recently, TapImmune displayed new data authored by Mayo Clinic researchers, supporting strong generation of T-cell immunity at higher levels than seen with other drugs for breast cancer and prompting initiation of a Phase II clinical study at Mayo for TPIV 100/TPIV 110. An astonishing 90% of patients in Phase I led to belief the drugs could prevent disease recurrence, control metastases, and, possibly, regress tumors which would allow TPIV 100/TPIV 110 to manage breast cancer as a chronic disease. If later studies show similar results, TapImmune's therapy would outpace competitors in the cancer immunotherapy arena and create a new age for breast cancer survivors.

TapImmune has shown breast cancer data at the American Society of Clinical Oncology (ASCO), proving its drugs motivate human immune cells to biologically stimulate other cells to effectively treat disease. Their vaccines are clearly creating a robust T-cell response. Use of TapImmune's technology in combination with checkpoint inhibitors and antibodies creates a multi-billion market opportunity. Partners like Mayo, unsurpassed in clinical talent and, recently, the Vaccine & Gene Therapy Institute of Florida, a nonprofit research institution committed to the study of the human immune system, will be valuable to TapImmune's future goals.

In September 2015, TapImmune released good news from Phase I studies in triple negative breast cancer (TNBC) that led to the Department of Defense's (DOD) $13.3 million grant to fund a 280 patient Phase II to be done at Mayo. TNBC occurs in 20% of all breast cancers that lack important hormones found in breast ducts that would otherwise thwart abnormal cell growth. Fatality is high - a 53% risk of death if chemotherapy is not undertaken very soon after diagnosis.