FYI - brand new longitudinal LCIS study published

boobymcferrin

Hi all,

In case you are interested, the Journal of Clinical Oncology just published the results of a 29-year longitudinal study on LCIS and breast cancer risk. (September 14, 2015) You can go to to their website and request a free copy through patient access. Basically, they found that LCIS confers a 2% risk per year following diagnosis, with a 26% rate at 15 years (at which it may or may not plateau - there haven't been enough follow-up studies beyond 15 years to really determine).

The only factor they found that increased the overall risk above 2% was the ratio of total pathology slides to the ratio of slides that showed LCIS. The only factor they found to decrease the overall risk was chemoprevention (which reduced the risk to approximately 1% per year).

The full text was interesting and wasn't that hard to get a copy of. I'd encourage you to check it out!

http://jco.ascopubs.org/content/early/2015/09/14/J...

Girl53

Booby: Thanks for this...will look forward to reviewing it. Meantime, I have a question about LCIS: Does it remain a factor for elevated risk contralaterally, even with treament of a breast cancer on one side? In other words, if I had been diagnosed with LCIS previously, and then diagnsosed with and treated for a cancer in my right breast, isn't my left breast still at elevated risk throughout my lifetime? And now new info says this risk is 2% per year (without chemopreventive), not 1%?

boobymcferrin

hi girl53,

I am not sure about the first part of your question (my guess is the answer is "probably"), but yes this new study suggests 2% per year instead of the previously suggested 1%. They of course though say this is just their study and others showed the 1% risk. But it is one of the first longitudinal studies of LCIS for this many patients, so I'm tending to trust the info.

boobymcferrin

Somebody just published a quick recap of the study for those who would rather read that.

http://www.pm360online.com/lcis-2-annual-cancer-ri...

leaf

A belated thank you for posting this, boobymcferrin! I think its interesting that they concluded that Common clinical factors used for risk prediction, including age and family history, were not associated with breast cancer risk. (emphasis mine). Since I've been on this site for almost 10 years, I thought I'd never see a study this large about longer-term LCIS. (I've seen some LCIS studies that describe a 2-5 year followup as 'long term' (excuse me??). I am having trouble in getting a copy of the original article though. Did you pay for your copy?

boobymcferrin

Hi Leaf,

I did not end up paying. Here's what I did:

I clicked "full text" to access it.

Then I clicked "patient access" at the bottom.

Then you'll see the name of the article and the price listed as $0.00

Click continue, agree to the terms and conditions, then click accept.

You'll eventually have to input your email and some other stuff and then they will email the full PDF of the article to you within 24 hours. It took about 4 hours for me to get mine.

Hope this helps!

Alittleknowledgeisdangerous

yes, I am interested and thanks for your post. LCIS is not widely studied and this was encouraging to see.

I have pretty much forgotten my LCIS diagnosis, and only think of it when I have an appointment, but checked in today to see what's new. The article prompted me to look again at my biopsy report from lumpectomy. I hoped to find my tumor volume, the ratio of positive slides to total slides. The report describes where 13 slides originated, but does not say which ones had LCIS. Microscopic diagnosis : lobular neoplasia ranging from atypical lobular hyperplasia to lobular carcinoma in situ, extensively present.

I am presuming, therefore, that LCIS was in each slide and tumor volume was high. I will ask at my next appointment. Meanwhile, any lab savvy people have an opinion?

And I will continue the Aromasin. Side effects are calming down after eight months.

Abutterfly

Amazing information. Met with Genetic doctor last week and she confirmed that my decision not to take tamoxifin was a wise one for me. I am on a screening schedule.

Crescent5

Huh?

Abutterfly

I have extensive medical history. Tamoxifin could be potentially harmful for me. I am presuming that the Huh? was directed my way.