Hypofractionation vs conventional fractionation-bc radiotherapy

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http://www.sciencedaily.com/releases/2015/08/15080...

http://www.medpagetoday.com/HematologyOncology/Bre...

'"AMA Oncology will publish two studies, a commentary and an author audio interview examining outcomes in women with breast cancer who had breast-conserving surgery and were treated with hypofractionated radiation therapy (shorter courses of radiation treatment administered in larger daily fraction sizes) compared with longer courses of conventionally fractionated radiation therapy.".........

"These studies collectively illustrate significantly lower rates of patient- and physician-reported early morbidities with hypofractionated therapy, providing critical support for this growing treatment modality. ... With comparable tumor control, lower costs and reduced morbidity, hypofractionation should be strongly considered for the majority of patients with early-stage disease."

Journal References:

1. Benjamin D. Smith, MD et al. Acute and Short-term Toxic Effects of Conventionally Fractionated vs Hypofractionated Whole-Breast Irradiation. JAMA Oncology, August 2015 DOI:10.1001/jamaoncol.2015.2666
2. Lori J. Pierce, MD et al. Differences in the Acute Toxic Effects of Breast Radiotherapy by Fractionation Schedule: Comparative Analysis of Physician-Assessed and Patient-Reported Outcomes in a Large Multicenter Cohort. JAMA Oncology, August 2015 DOI:10.1001/jamaoncol.2015.2590
3. Jennifer R. Bellon, MD et al. Hypofractionation for Early-Stage Breast Cancer: No More Excuses. JAMA Oncology, August 2015 DOI:10.1001/jamaoncol.2015.2605