High Ki67, Low Mitotic Index?

tshire

I'm wondering how many other women were given a high Ki67 score with a very low mitotic index.

My only Ki67 measurement was from my biopsy, it was 34%. They did not re-test on the surgical pathology. My mitotic index however was a grade 1, with less than 1 mitotic feature seen per 10 HPF. My surgeon could not explain the discrepancy. I am still waiting for appointments with MOs.

However, I did ask a professor and PhD in microbiology at UT Southwestern Medical School in Dallas why this could happen. He explained in layman's terms to me:

"There are many regulators of mitosis in the cell that control certain checkpoints that allow the phases of cell division to proceed. You may have one marker that says "ok, go" and that leads to Ki67 expression. But another checkpoint protein might say "stop", and then mitosis, despite Ki67 being high, does not progress. In most cases the Ki67 correlates to the mitotic rate. But in your case, when they've actually seen the absence of mitosis under the microscope, and the Ki67 is the oddball result, it doesn't correlate. Ki67 is a valuable data point, but it doesn't negate the fact that pathology shows that the cells are not actually dividing."

Anyone else have any info or thoughts on this? I think my Ki67 is the only reason I got a 20 Oncotype instead of a much lower score.

MarieTherese

I had Ki67 35 and mitotic 1. Waiting for oncotype. Fingers crossed

MT

tshire

Please let me know how it goes!

Meow13

I don't know my ki67 but my oncodx was 34. My mitotic rate was 1.