Bone Drugs (bisphosphonates) May Thwart HER-Driven Tumors

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http://www.medpagetoday.com/HematologyOncology/Oth...

"Researchers have discovered that bisphosphonates inactivate human epidermal growth factor (EGF) receptors to exert antitumor effects, and they say the widely prescribed osteoporosis drugs may prove to be a cheap and useful adjuvant to current therapies for HER-driven cancers."

"Bisphosphonates directly bind to and inhibit HER kinases, including commonly mutated forms that drive non-small-cell lung cancer and other cancer growth and resistance to tyrosine kinase inhibitors, according to two studies published online this week in the journal PNAS Early Edition, by researcher Mone Zaidi, MD, of Mount Sinai School of Medicine, in New York City, and colleagues.

Bisphosphonates Lower Risk for Some Breast, Colon Cancers

If the findings are confirmed, bisphosphonates could potentially be repurposed for the prevention and adjuvant treatment of breast, lung, and colorectal cancers that are driven by HER (human EGF receptor), the researchers wrote."