making triple negative bc more susceptible to chemotherapy

besa

http://www.sciencedaily.com/releases/2014/12/14120...

http://medicalxpress.com/news/2014-12-toughest-bre...

http://www.pnas.org/content/early/2014/11/26/14214...

"In mice that were implanted with triple-negative breast cancer cells, treatment with digoxin and paclitaxel decreased tumor size by 30 percent more than treatment with paclitaxel alone. The combination therapy also decreased the number of breast cancer stem cells and the levels of MDR1. Treatment with digoxin plus a different chemotherapy drug, gemcitabine, brought tumor volumes to zero within three weeks and prevented the immediate relapse at the end of treatment that was seen in mice treated with gemcitabine alone."

note: as the abstract states - some of these HIF inhibitors are already FDA approved.

Meadow

Thanks for sharing these articles!