How red wine prevents cancer

Heidihill

http://www.sciencedaily.com/releases/2014/12/141203161134.htm

I knew grapes alone didn't cut it for me. 

dlb823

Thanks for the article, Heidihill. I wonder if there's any research pointing to a resveratrol benefit for breast cancer? In the past, when I was inbetween dx's, my ND didn't think it was necessary; and since the better brands are pretty pricey, I have never added it to my regimen. So I'm just wondering if anyone has seen research suggesting a specific benefit to us?

I still tend to believe some research from maybe two years ago that made a distinction between wine being okay if you have or had IDC, but possibly not as safe if you've had ILC. For that reason, my wine consumption will regretfully remain limited to an occasional glass for special occasions. Deanna

new_direction

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710299/
Concentrations are greater in red compared to white wine, due to the variable amounts of time that red grape skins are present during processing (17). However, resveratrol is metabolized quickly: consistent intake of two glasses of red wine daily would be equivalent to a dose of ~27 µg/kg body weight for a 70 kg individual, leading to detectable concentrations of derivatives but not free resveratrol (9). Thus these low levels may not result in bioeffective concentrations.

http://www.ncbi.nlm.nih.gov/pubmed/24559007
a bit off-topic but interesting to see recommendations of dietary patterns.

http://www.ncbi.nlm.nih.gov/pubmed/9324209
A relative risk of 3.96 (95% CI: 1.59-9.84) was found for a monthly consumption higher than 4 liters per month.

http://www.ncbi.nlm.nih.gov/pubmed/18440826
Although no association between the pattern of total alcohol consumption and breast cancer was found, the type of alcoholic beverage seemed to play an important role in this association. Our results support the hypothesis that there is a threshold effect that risk decreased or was not modified for consumption under a certain threshold. Above that threshold, risk increased, however. The drinking pattern of each type of specific beverage, especially wine, seems important in terms of alcohol-breast cancer association. Low and regular wine consumption does not increase breast cancer risk.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046451/
Risk factors for ductal and lobular breast cancer: results
There was suggestion of a stronger positive association between increasing daily alcohol intake and risk of lobular cancer (P-het = 0.11 for each five-unit increase).
Although we did not observe significant heterogeneity between daily alcohol consumption and risk overall, we did observe a positive association between increasing intake and risk which was suggestively stronger for lobular cancers (P-het = 0.11). Despite these findings, there was significant heterogeneity for this association when we limited the analysis to ER-positive and PR-positive tumors (P-het = 0.02).

Heidihill

Deanna, your ND is probably right. I wouldn't go for supplements because how resveratrol works is still a mystery. It is supposedly chemically similar to estrogen. Whether that's a good thing or not, who knows?

Heidihill

Thanks for the links, newdirection!