Some BC tumors Hijack Patient Epigenetics to Evade Drug Therapy

cp418

http://www.healthcanal.com/cancers/breast-cancer/49197-some-breast-cancer-tumors-hijack-patient-epigenetic-machinery-to-evade-drug-therapy.html

Some Breast Cancer Tumors Hijack Patient Epigenetic Machinery to Evade Drug Therapy

PITTSBURGH – A breast cancer therapy that blocks estrogen synthesis to activate cancer-killing genes sometimes loses its effectiveness because the cancer takes over epigenetic mechanisms, including permanent DNA modifications in the patient’s tumor, once again allowing tumor growth, according to an international team headed by the University of Pittsburgh Cancer Institute.