Endoxifen Shows Promise as Breast Cancer Treatment

cp418

http://www.sciencedaily.com/releases/2013/12/131212185835.htm

First In-Human Trial of Endoxifen Shows Promise as Breast Cancer Treatment

 A Phase I trial of endoxifen, an active metabolite of the cancer drug tamoxifen, indicates that the experimental drug is safe, with early evidence for anti-tumor activity, a Mayo Clinic study has found. The findings indicate that Z-endoxifen, co-developed by Mayo Clinic Cancer Center and the National Cancer Institute (NCI), may provide a new and better treatment for some women with estrogen positive breast cancer and, in particular, for those women who do not respond to tamoxifen and aromatase inhibitors. Results of the first in-human trial were presented today during the 2013 San Antonio Breast Cancer Symposium.

Fallleaves

I thought tamoxifen had to convert to endoxifen to be effective, so it sounds like this just cuts to the chase, and eliminates any interference in the conversion (genetics or low vitamin D). Seems like it will be more effective.