HER2 Equivocal but treated as TN?

AlishaCatherine

UPDATE:

My mom will be receiving Herceptin.

I was able to find the new algorithm which has been updated based on an October 7th clinical guideline updates. Now based on the current guidelines criteria for being Her2 positive status is indeed a FISH ratio >=2. Her oncologist confirmed this. Though what's worrisome is she only realized after I brought her the new information. I hope other patients don't miss out on an opportunity for targeted treatment.

This is huge news for us and probably many others who were right on the border.

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My mom's original biopsy came back with a HER2 score of 1.8. For some reason, just this weekend, I realized we never got the FISH test results back from after the lumpectomy when a new biopsy was sent for pathology. I asked to see it today. FISH came back at a 2.0. This is technically still equivocal, but now I believe she qualifies for Herceptin. In fact, at the bottom of the new report it reads, "Available clinical trial data do not support excluding patients from trastuzumab treatment with an HER2 FISH ratio of 2.0 or greater." Up to this point she has been treated as Triple Negative.

I am looking for information, experiences, opinions about Herceptin treatment for those with equivocal HER2 results. Please share. (I also posted this in the HER2+ boards.)

AlishaCatherine

No one?

AlishaCatherine

Updated post.