BRCA1, BRCA2 AND BART negative

mbetts

My identical twin and I both had breast cancer. I was diagnosed 10 years after her diagnosis and now 4 years later she has breast cancer again. Could there be another gene or mutation or could we have gotten a false negative BRCA test? Any information would be appreciated. Thanks!

Moderators

You may find these links about genetics and breast cancer helpful, or interesting.

http://www.breastcancer.org/symptoms/testing/genetic

http://www.breastcancer.org/risk/factors/genetics

http://www.breastcancer.org/risk/factors/ask_expert/2008_03

Thinking of you and your twin! 

The Mods

thirdgenerationmomof2

Check with your insurance company and see if they will cover BreastNext testing. This test covers 14 other genes that are linked to breast cancer. I had mine done in April and waiting for results. Results take 12-16 wks to get back. I have my mom, gmom and me all with bc. Genetic counselor thinks I may be positive for one of these other genes. I am both BRCA and BART negative as well.



Good luck!

argynis

I was also tested negative for a BRCA1/2 mutation and was offered to do a p53 test after that.

They found that I have a genetic mutation on the p53 gene - also called Li-Fraumeni syndrome which unfortunately increases your risk not only for breast cancer...