UCSF Study on Genetic Predisposition for LE

kira66715

UCSF Study on Genetic Predisposition for LE

kira66715

Now they say they're the first, but Finegold at Pitt has already published that women with certain genes that are present in primary LE will get secondary LE easily. They did use bioimpedance (this was done at Stanford who has gotten a big grant from impedimed) but it's still a valuable study, IMO. PLOs one is a free on-line journal--I'm not finding the link to the article yet.

http://www.ucsf.edu/news/2013/04/105101/genetic-markers-linked-development-lymphedema-breast-cancer-survivors

A new UC San Francisco study has found a clear association between certain genes and the development of lymphedema, a painful and chronic condition that often occurs after breast cancer surgery and some other cancer treatments.

The researchers also learned that the risks of developing lymphedema increased significantly for women who had more advanced breast cancer at the time of diagnosis, more lymph nodes removed or a significantly higher body mass index.

Bradley Aouizerat, PhD

The study is the first to evaluate genetic predictors of lymphedema in a large group of women using a type of technology, bioimpedance spectroscopy, to measure increases in fluid in the arm. Bioimpedance spectroscopy is a noninvasive procedure that allows one to measure body composition including an increase in fluid in an arm or a leg.

The study, which involved some 400 women who were tracked over four to five years, will be published online on April 16 in PLOS ONE.

“The genetic markers found in our study make perfect sense,” said senior author Bradley Aouizerat, PhD, a professor at the UCSF School of Nursing in the department of physiological nursing. “These genes are ‘turned on’ later in the development of our lymph system and blood vessels. They appear to play a role in the ability of our lymphatic system to function on an ongoing basis. It is possible in some individuals who have changes in these genes, that lymphedema could develop after an injury like breast cancer surgery because these genes do not function properly.” 

Christine Miaskowski, RN, PhD

Lymphedema is a swelling or buildup of fluid in the lymphatic tissues, typically in the arms and fingers but also commonly in the patient’s legs and trunk. It can occur after treatment for any form of cancer that affects lymph node drainage. The exact prevalence is unknown, and the onset of the condition can greatly vary, but as many as 56 percent of women who undergo breast cancer surgery develop lymphedema within two years, according to the National Cancer Institute. More than a half-million breast cancer survivors in the United States are estimated to be afflicted with the condition.

Lymphedema can be debilitating, causing scarring, discomfort, disfigurement, difficulty in exercising, walking or other daily activities. Some patients are unable to wear their usual clothing or jewelry because of the increased weight and size of their affected limbs. There’s no cure for the condition – treatment generally centers on controlling pain and reducing swelling.

Genomic Determinants of Lymphedema

To date, much of the research on lymphedema focused on identifying which women were at greater risk for the development of the condition, and relied only on patient self-reporting or on data from their medical charts.

In the new study, the authors hypothesized that genomic determinants were behind some of the variations in the occurrence of lymphedema as well as the time of onset of the condition.

The study involved 410 women who were at least six months post-treatment for breast cancer surgery on one breast, and either had lymphedema in their upper extremity or did not have the condition.

The women were assessed at the Clinical Research Center at the UCSF Medical Center at Mt. Zion, one of eight clinical sites in the Bay Area managed by UCSF’s Clinical and Translational Science Institute.

As part of the research, the women underwent spectroscopy measurements of their arms, and genomic DNA was extracted. Genotyping was performed blinded to the women’s lymphedema status.

The researchers found that women with lymphedema had:

• More advanced breast cancer at the time of diagnosis;
• A higher number of positive lymph nodes;
• Were more likely to have a significantly higher body mass index.
• The authors also found associations between lymphedema and four genes known to play a role in the development of lymphedema.

“These findings suggest that complex interactions may exist between a variety of patient characteristics and genetic markers that place some women at higher risk for the development of lymphedema,’’ said lead author Christine Miaskowski, RN, PhD, a professor at the UCSF School of Nursing in the department of physiological nursing. “Our hope is that once our findings are confirmed in a future study, we will be able to identify women at higher risk for lymphedema prior to breast cancer surgery, and initiate measures to prevent the development of this devastating condition.”

The study was funded by grants from the National Cancer Institute (CA107091 and CA118658) and the American Cancer Society.

Here's the link to the article:

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0060164

NatsFan

So all those surgeons and hospitals who swear no patient of theirs ever gets LE must be genetically screening all their patients before accepting them, right??? 

On a serious note, I know some of us on this thread have speculated about a genetic predisposition for LE.  I just found out a few months ago that a maternal aunt of mine who had a MX in the 60's suffered from horrible LE for the rest of her life.  I was astonished and began to wonder if the fact I developed LE was just a coincidence or not.  Interesting stuff.

purple32

Intriguing!  thanks kira.

I know a girl who has lower primary, got BC but never developed secondary  ( thank goodness)

I was studying genotypes in jr. college. WTH couldnt they have developed a test and just gave it to all of us ?  grrr... wrong thread/sorry.

Marple

My maternal grandmother developed LE after a radical mast. and radiation.  This was back in the 60's.  So maybe for me there is a genetic predisposition.  On the other hand, she lived to be over 100.

Purple, VERY glad for your friend. 

M360

Like this article but find it funny that I have Breast Cancer and Lymph-edema but UCSF sends it's cancer patients like myself who have such out to another hospital to have treatment of such?!

Never even heard or recommended for the study and I'm at UCSF every three weeks.

My sister who is a year older than myself, has Lymph edema and uses a Flex machine which I never heard of but her doctor has her using at home on the East Coast.  My Mother and two of my Aunts also suffered from Lymph-edema.  I've had Genetic Testing at UCSF wonder if they will tell me if this is so also for LE?

vlnrph

Bumping. Also want to mention that the testing M360 refers to in the comment above probably mostly looked at the BRCA genes, the ones possibly involved in LE are different...

purple32

ADDITIONALLY
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629060/

full text free