I'm I one of these " High Risk Women"???

1american

Just came across this today...... Clear link between neurotensin and Cardiovascular disease, type 2 diabetes, and breast cancer. Neurotensin is a satiation hormone that is produced in the brain and the gastrointestinal tract. This is the first time a satiation hormone has been linked to these three common diseases in women. I had some very interesting reading today ..... But now I might be getting a little concerned . The little bit of background i put in my other post did not include that within the last year I was diagnosed with type 2 diabetes then a few motnths later it was high cholesterol ( over 300 ) and now I'm waiting for my biopsy ( birad 4 )..... Now for these three being common in women ...... Are they common all at the same time??? I called dr office and now have an appt for the 30th to get blood test. That is one day before the biopsy.

The findings of this study is to catch these things early to help prevent them from happening but my question is .....if this is the case of having elevated levels of this hormone and already developing at least two out of three at this point ( really hoping on not having the third ) ... What can be done????

leaf

There are links of breast cancer to many, many other conditions.  Remember, the science of breast cancer risk is in its infancy.  There are certain conditions that may significantly increase your risk of breast cancer, such as having a deleterious BRCA mutation, or perhaps a significant family history such as having a 1st degree relative with breast cancer particularly premenopausal, or having radiation *therapy* (not simple diagnostic chest Xrays), such as treatment for Hodgkin's lymphoma, or being involved in significant radiation exposure such as Hiroshima atomic bomb blasts.  Remember, about 70% of women who get breast cancer have no obvious risk factors for breast cancer besides being a woman.  Even all the other factors associated with breast cancer risk listed in the Gail model http://www.cancer.gov/bcrisktool/  do NOT give significantly better information on whether *you* as an individual will get breast cancer.

In other words, I have classic LCIS, but many places do NOT categorize me as being a 'high risk woman'.  There is a lot unknown about LCIS, but most people estimate my lifetime risk of breast cancer is about 25-40%.  This is more than the 'average' woman's lifetime risk of about 13%.

Even known breast cancer risk conditions such as having LCIS or dense breasts do not get the risk curves different enough to be able to separate the people who will or won't get breast cancer. (LCIS is thought to be one of the largest non-cancerous breast cancer risk conditions that can be seen under the microscope.  Certain deleterious BRCA mutations are thought to have up to a 95% lifetime incidence of breast cancer, and I don't know what the rate is for Hodgkin's disease survivors, but its probably higher than the numbers that are usually tossed around for LCIS, about 20-40%; my 2nd opinion said 10-60%, but probably closer to the lower end of that than the upper end.)

They can link many factors with increased breast cancer risk - but these are *in populations*.  In other words, they might know that more cases of breast cancer are found in a population with risk factor X.  But predicting WHICH of these individuals in this group with risk factor X will get breast cancer is a whole different ball of wax.  For more complex statistical information, you may want to check out this editorial in a peer-reviewed medical journal.  http://jnci.oxfordjournals.org/content/98/23/1673.full.pdf