Nelfinavir ... Inhibit Growth Of HER2-Positive BC cells

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Nelfinavir May Selectively Inhibit Growth Of HER2-Positive Breast Cancer Cells.

Medwire (10/15, Williams) reports, "A drug used to treat HIV infection may be a new treatment line for patients with an aggressive type of breast cancer," according to a study published in the Journal of the National Cancer Institute. "In vitro findings show that the aspartyl protease inhibitor, nelfinavir, selectively inhibits growth of HER2-positive breast cancer cells in vitro and in vivo, including cell lines with proven resistance to the current HER2-positive agents trastuzumab and/or lapatinib."

http://www.medwire-news.md/494/101940/Pathology/HIV_agent_offers_HER2-positive_breast_cancer_hope.html