Natural Aromotase inhibitors

lightandwind

Is anyone using natural aromatase inhibitors, if so what, and how much? is it working? I am beside myself because my body cannot take the AIs. I have a weak liver and have been flat on my face, w/ no appetite. I have chrysin, querticin, dim, reservatol, d3, curcumin, and green tea extract. What am I missing? How much chrysin do you take? how much of all of these do you take? what will do the job? what has worked for you? I know some of you are doing this and want to hear from you.  I had an oophorectmy and mastectomy 3 weeks ago. I am 43. Please help! Thank you! 

Anonymous

lightandwind, the combo I take includes I3C, DIM, calcium D glucarate, turmeric, green tea extract, rosemary leaf extract and a trademark of sulforaphane.  I've researched all of those; they all process excess estrogen and aid the liver in doing its job.  I need to add grape seed extract to my protocol

Here's a copy of my post on the Natural Girls thread, priceless btw 

Phase I clinical trials have begun on the botanical dietary supplement IH636 grape seed extract for the prevention of breast cancer in postmenopausal women who are at increased risk of developing breast cancer. The IH636 extract has a high concentration of proanthocyanidins and has been shown to inhibit aromatase using in vitro and in vivo models

The most active natural product extracts from testing in the microsomal aromatase inhibition assay, reported as % inhibition, comprise the ethyl acetate partition of Dioon spinulosum Dyer ex Eichl. [104], the ethyl acetate partition of Encephalartos ferox Bertol. f. [104], a 75% methanol reflux extract of Riedelia Meisn. sp. [105], a 75% methanol reflux extract of Viscum album L. [105], the methanol partition of Cycas rumphii Miq. [104], the methanol and ethyl acetate partitions of Cycas revoluta Thunb. [104], a 75% methanol reflux extract of Alpinia purpurata K. Schum. [105], and a 75% methanol reflux extract of Coccothrinax Sarg. sp. [105]. The natural product extracts that were most active in the microsomal aromatase inhibition assay reported as PCA included five red wine varieties (Vitis L. sp.) from various wineries, with the most active being Cabernet Sauvignon from Tanglewood (France) [86, 106, 107]. The hexane partition of the leaves of Brassaiopsis glomerulata (Blume) Regel (Araliaceae) was found to be active in microsomes [108]. The methanol and chloroform extracts of Garcinia mangostana L. (Clusiaceae) (mangosteen) were also strongly inhibitory against aromatase in microsomes [109].
Euonymus alatus (Thunb.) Sielbold ("gui-jun woo" in Korean folk medicine), a dichloromethane partition of Isodon excisus Kudo var. coreanus [110], a water reflux extract of Scutellaria barbata D. Don [111], and a polyphenol-enhanced extract of green tea (Camellia sinensis Kuntze) [112]. Another study reported results in units/100 g wet weight (one unit was defined as the dose required for 50% inhibition) and found tea (C. sinensis), coffee (Coffea L. sp.), cocoa (Theobroma cacao L.), collards (Brassica oleracea L.), and tomato leaves (Lycopersicon esculentum Mill.) to strongly inhibit aromatase using a microsomal assay [113]. Interestingly, this study also reported that cigarette smoke (obtained using methylene chloride and aqueous traps) and tobacco leaves (70% ethanol extract; Nicotiana tabacum L.) also potently inhibited aromatase, as reported in cigarette equivalents [113].

xanthohumol-rich stout beer in choriocarcinoma-derived JAR cells [114], a water extract of grape seed extract (Vitis L. sp.) in MCF-7aro cells [85], a water reflux extract of white button mushrooms [Agaricus bisporus (J. Lange) Imbach] in MCF-7aro cells [115], red clover flowers (Trifolium pratense L.) in a MCF-7 cell dual assay for aromatase inhibition and estrogenicity [116], mangosteen (Garcinia mangostana L.) in SK-BR-3 cells [109], and Brassaiopsis glomerulata (Blume) Regel in SK-BR-3 cells [108]. The red clover flowers were found to inhibit aromatase at low concentrations and were also estrogenic at high concentrations.

Pinot noir from Hacienda (Sonoma, CA)

Apigenin (5,7,4'-trihydroxyflavone, 8) and quercetin (3,5,7,3',4'-pentahydroxyflavone, 37) have been tested numerous times for aromatase inhibition. Apigenin (8) was found to be strongly active in microsomes

7-Hydroxyflavone (26) has been tested several times and has shown strong aromatase inhibition
Hesperetin (5,7,3'-trihydroxy-4'-methoxyflavanone, 53) [121, 133] and eriodictyol (5,7,3',4'-tetrahydroxyflavanone,50) [133] were each tested twice in microsomal aromatase assays and found to be strongly active. 8-Prenylnaringenin (62, isolated from Humulus lupulus L.) was one of the most active natural product compounds tested for aromatase inhibition
an epidemiological study inferring aromatase inhibition through changes in estradiol levels demonstrated that estradiol levels were lower for people with higher EGCG (99) intake [147].

Furthermore, EGCG (99) has been tested using an in vivo Swiss-Webster mouse model measuring ovarian aromatase activity and was found to inhibit aromatase activity by 56% at 25 and 12.5 mg/kg [148]. Theaflavin (101) and theaflavin-3,3'-gallate (102), both isolated from Camellia sinensis Kuntze (black tea), were found to strongly inhibit aromatase in microsomes

Nearly 300 natural product compounds have been evaluated for their ability to inhibit aromatase, in noncellular, cell-based, and in vivo aromatase inhibition assays. Flavonoids have been tested most frequently and generally found to be the most active class of natural product AI compounds.

Some of the more active flavonoids included apigenin (8), chrysin (11), 7-hydroxyflavone (26), isolicoflavonol (27), (2S)-abyssinone II (45), (2S)-2',4'-dihydroxy-2"-(1-hydroxy-1-methylethyl)dihydrofuro[2,3-h]flavanone (49), eriodictyol (50), 8-prenylnaringenin (62), 3'-[γ-hydroxymethyl-(E)-γ-methylallyl]-2,4,2',4'-tetrahydroxychalcone 11'-O-coumarate (75), isoliquiritigenin (77), and rotenone (132). Other very active AI compounds included the xanthone, γ-mangostin (239), the sesquiterpene lactone, 11βH,13-dihydro-10-epi-8-deoxycumambrin (211), and the anthraquinone, benzanthraquinone I (249).

AIs from edible plant materials may eventually be appropriate for primary prevention of breast cancer in postmenopausal women (e.g., lower toxicity due to history of human consumption). Botanical dietary supplements or foods that are ingested regularly and act as AIs may have a role in breast cancer chemoprevention or chemotherapy for postmenopausal women.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074486/ 

lightandwind

Thank you so much Maud,

I'll have to check out sulfurafane. about how much of each do you take? What do you think of IP6?

Anonymous

Hi L&W, the combo I take is all in one pill, I take 4 of them, 2 in a.m. and 2 in p.m.  

Inositol (IP6) is great, lots of studies like this one to back it up.  I also want to add it to my protocol, it's now a matter of getting organized (alternating) with all the supps and monetary considerations....

http://jn.nutrition.org/content/133/11/3778S.long

You'll find an endless list of supps, molecules and nutrients with anti-cancer properties.  The hardest part is to prioritize your list 

I'll have to list all the supps I take in my profile when I have a moment 

DavidStoner

Mushrooms  are source of  linoleic acid, which acts like an aromatase inhibitor. In particular mushrooms from the species Agaricus, like the white button mushroom.

One that is very popular in Japan is the Agaricus blazei Murrill, it is known as a medicinal mushroom and a lot of research has been done on its anti-cancer potency. It is an aromatase inhibitor and also normalizes the immune function, which is very important to prevent secondary infections and metastasis, and also to neutralize the side effects of chemo and radiation. It is available as a concentrated supplement in capsules.

If you want to try it, make sure you buy an extract, because humans cannot digest raw mushrooms. Here is an explanation about the science behind it: bit.ly/V5WDSt

Too bad, because extracts are much more expensive than dried and powdered mushrooms.