taxotere side effects

stagefree

Jeanie,

My initial therapy was Taxotere + Xeloda, but having hospitalized due to severe tachycardia attack thanks to Xeloda (only took it for 3 days), I had to continue with Taxotere alone, about which I have already posted. It is not an easy chemo, but has been doable for me. Will be having my last infusion next week. I have steroids the night before (Kordexa pill), the day of (IV) and the following two mornings (pill again). Other than that needed no additional steroid IV, but then the SE's are so different for each person. Hope you feel better soon.

Ebru  

jeanieb2

bcbarbie10 - Thanks for the info, I did not want to take the Benadryl for 3 or 4 days because it seems to make me even more tired.  I am glad to hear that the side effects will wane some after this first week, I am not to worried about the hair loss, it could always be worse, although it has been nice to have it.

stagefree - I am sorry you had such a time with the Xeloda, I have been fortunate enough to take it with only the fatigue, hand and foot syndrome and nausea.  I took cytoxan, methotrexate and 5Fu, 20 years ago when I had breast cancer but I do not remember feeling so tired, of course my memory may have faded from then and I am 20 years older so maybe I did feel like this but just do not remember.  Have you had scans since you started this and how has it done on the tumors?  I do not know right now how long I will have to take this, he said something about 3 or 4 treatments and then scans again but I will have to check the next time I go in and see my onco.

I also wondered about the diarrhea, can you take any of the over the counter meds for this?  I have constipation with Xeloda but since getting the taxotere it has changed. 

Hikergal

bcbarbie, no I am not on Herceptin, my HER2 was equivocal.

jeanjeb2, so sorry to hear you are back on chemo.  I haven't taken or heard of Xeloda.  I lost my hair at day 16 after taxotere and cytoxan combination.  The first week after treatment was bad but I usually started to feel a bit better at day 7.  Drink lots of fluids.  I know that is even difficult, water even tasted bad to me.  Also what worked for me was to make smoothies with yogurt and flax seed to help with the GI issues.  I agree with stagefree that forcing yourself to eat that first week is important.  I iced my mouth and fingers/toes during the infusion and did not end up with any mouth sores or problems with my extremities. 

Thx PA eaglesfan for the tip on eye cleanser.  Where can I purchase it?  I have to say the taxotears are extremely irritating, people always think I am crying as I have to keep a kleenex handy for the tearing.  

stagefree

Jeanie, I will be having my first CT scan after I complete the 8th cycle, will post the results later on. I was in wheelchair & on oxygen fulltime before dx, now I can climb stairs, go out for moderate walks and have my pleural effusions treated mostly. Taxotere, as I have read on the boards is a tough chemo but achieves very impressive results. So I am very thankful to Tax. I experienced diarrhea once along the way, when my doc suggested Florastor. 

Ebru 

jeanieb2

Ebru - I am so happy to hear of your good results.  That is just fantastic news.  I love to hear good results like this.  I had 2 years on Femara, a few months on Aromasin, then a year on Xeloda and now Taxotere and was beginning to wonder if I was going to have to go hopping from one chemo to another but this certainly gives me hope that I will be able to be off of it sometimes, which will be great.  Is Florastor a prescription or an over the counter?  Thanks for the info it certainly gives me hope, I have been dealing with this very well and today seems to be kind of a low day for me, maybe it is because I am tired or just part of the process.  I know God has truly blessed me and for that I am thankful, great family, friends, home and my girls are 31 and 33 so I did get to see them grow up, that was a plus right there. 

ljhm

The days 3 through 7 are the worst. Yesterday was the worst day I've ever had.  Achy, sore throat, blurry vision, weak.  But I know it will get better.  Yes you will probably lose most of your hair or all of it. I didn't shave mine so have some left but I look better with my wig on.  Only wear it when I go out.  Drink lots of fluids, eat ice chips for your mouth sores, and rest.  Like all things this too shall end.

stagefree

Jeanie, if I can remember right, Florastor should be OTC. I am happy you feel better. As long as you don't develop high fever and keep eating & drinking, you will get better soon. Oncs move between chemo & AI's throughout therapy for ER+ patients, so we are lucky I am also thankful for each precious day I get to spend with my son(7) & my loving DH. Hope for the cure soon!

Ebru 

bcbarbie10

Gatorade helps me a lot. I try to drink at least one regular bottle, or two, a day, between my forced water intake, whether or not there's diarrhea. Then on the really bad days, i resigned on the trying to eat part. I just down a protein shake for what it's worth, and just try to make up for it on the semi good days.



Stagefree, hope your scans turn out good.



Im one of the lucky ones with the hair, i guess!

jeanieb2

How long does the diarrhea last, is it the whole time or just the first few days?  I was hoping it would be only the first few days, and does it hit while you are getting treatment.  I was on Xeloda this time and it causes constipation for me but the diarrhea hit some yesterday and today, treatment with Taxotere was Thursday.  I will try the Florastor if I can find it and get some gatorade.  I am having a hard time wanting to eat anything.  Nothing sounds good.  I have had a banana, yogurt, protein shake with milk and that is about it.  I seem to be doing OK with the water intake but could do better, maybe with the gatorade that will help.  What are some of the better flavors of that.  My taste for drinks is coffee, water and once and a while pop, do not like tea or juice but will do whatever is necessary at this point.  I have been trying to think of things to eat but so far nothing has come to mind so any ideas will be helpful.  I am thinking of making some pudding but know I need protein, maybe some peanut butter or eggs.

stagefree

boiled eggs (but not omlettes), I avoid milk as onc suggested, boiled potatoes (helps with diarrhea), NO coffee & preferably no tea -definitely off my list from day 1, lots of fresh green salad with each meal, some whole grain pasta with yoghurt, meatballs (but no other meat), simple turkey stew with just peeled fresh tomatoes, fresh pineapples, whole grain bread / WASA with saltfree cheese, apples, bananas are my favorites when I totally lose my appetite. I juice carrots daily, eat lots of fresh & dried apricots. well, these are the do'ables for me when I feel worst, definitely work for me.

Ebru 

PaEaglesFan

I found the OcuCleanse at Walmart where the contact solutions and eye drops are. My son had bad allergies and the eye dr suggested them to keep his eyes clear. You can also make a solution out of baby shampoo and water and just dip a cotton ball in that. The pads are individually wrapped, makes them nice to keep with you.

jeanieb2

ljhm - Thanks for the info.  Today is day 4 if you count the day I got the treatment, if not it is day 3 as I got it on Thursday.  I am very tired yet, diarrhea has set in, I am hungry but nothing sounds particularly good.  I hope diarrhea does not last the whole time.  As for the hair loss I am kind of expecting it and will just see what happens there.  I have a wig from 20 years ago, it was a short cut back then and has not changed much but will have to see, if not I will go to Look Good Feel Better program and see what they can help me with.  I need to find out for sure how long I need to be on this stuff.  He told me but you know how that goes, you can not comprehend everything when things are changing so fast.

 Ebru - All of the things you said you eat, if I eat them when I am normal I have diarrhea really bad, my stomach can not take much for fiber before it sends me running to the bathroom so I am not sure I can handle those things.  I will try and see if it works for me now.   It always helps to see what other people are doing and what works for them, it gives me ideas anyway.

 I really appreciate all of the help you have given me.

PaEaglesFan

Jeanie and any others going thru the post chemo "big D". My MO gave me the perfect formula for stopping it. I take 2 OTC anti-gas pills and 2 anti-diarrhea pills at the first sign of looseness. (I ALWAYS waited till the constipation passed before taking them.) That combo worked perfectly for me each time and I only had to take it once.
I am now 7 days pfc and feel almost human again. Still fighting the muscle weakness and general tired feeling and suspect I will be for some time.

Just take each day one at a time and even an hour at a time if need be ✌

jeanieb2

PAeaglesFan - thank you so much for the info.  I will try that and see how it works.  I will know for the next time for sure and take at the first sign.  I am glad to hear you are feeling almost human again at day 7, I was beginning to wonder when that would happen.  I just kind of thought it would be the first couple of days so I see a new hope on the horizon and it is just around the corner, I can muddle through the next couple of days that is for sure.  I will take your advice and try and take it hourly, but we all know how hard that is when we are so used to just getting up and doing whatever we felt like.  I will learn, maybe my sister is right and I am a slow learner , of course I won't tell her that........best wishes to all of you 

bcbarbie10

Jeanie, ljhm, ebru, how are you girls coping?



Im behind my crash days for this cycle. This one's kinder to me bec the onc decreased by dosage by 20%. however, i will ask him if it will be better/more effective if he gives me again the full dose for the last time. What the heck, this will be the last anyway, bring it on. Will ask.



PAEagles, cant wait to join you there!



Hang in there, ladies! It really isnt such a long ride. Tough, rough, but it does end. 😍



Hugs to all!

jeanieb2

bcbarbie10 - I was beginning to wonder if I was going to die from the chemo.  I took chemo 20 years ago and do not remember ever, ever, feeling like that, of course I was only 40 at that time so that could have made a difference.  I had it on Thursday, on Sunday but especially Monday I was beginning to wonder what was wrong.  I called the onco office and the nurse said I just really needed to rest, make sure to eat, especially protein, drink plenty of fluids, rest.  I thought I should be able to at least go to the doctors to have protime done but I could not even walk to the back of the office so I just came home and went to bed.  Yesterday was a little better and I think today may be even better.  Does it always hit this hard and should I just expect to stay in bed for 2 or 3 days?  I am just not use to laying down and resting during the day but I certainly have done that the last 5 days.  Does it get harder or easier?  I know the nurse said they would give me decadron the day before, the day of and the day after and that should help.  I only received it the day of because we did not know I would be taking it until the appointment.  I am just trying to plan my time and try and get things done that really need to get done in between feeling good.  I also have not had an appetite, which is very unusual for me and I can stand to lose about 30 pounds instead of gaining like they said I might, but I also know that not eating can make you feel worse.  I just want to know what to expect so I can plan for the next time.  It helps a lot when other people tell you how they reacted or how they coped with it, so thank you for your input, and I hope you have great scan results, please keep us posted, I love hearing that it does the job, it somehow seems to make it all worthwhile. 

 I have not let this whole thing get to me ever, even with the new occurances, but on Monday I did break down a little and ask my husband how long I could do this, he said as long as you need to, which I know he is right and maybe that was my low day I don't know, do other people feel this way sometimes also? 

Melrosemelrose

jeanieb- After reading your posts here, you are definitely one strong lady!!!!!!  I'm 5 weeks PFC and had Cytoxan/Taxotere regimen.  I took Decadron the day before chemo, the day of chemo and the day after chemo.  That steroid kept me up at nights but since I knew that it would, I tried not to fret about not sleeping and just rested.  You will need to make sure you eat when you take the Decadron since the drug taken without food can cause nausea.

As for eating, I had a cancer cook book given to me by the hospital cancer center called "Eating Well Through Cancer" by Holly Clegg and Gerald Miletello, MD.  The book has chapters of menu recommendations for certain side effects ( constipation, diarrhea, low white blood cell count, etc.), recipes and shopping menus.  It was my go-to book so I didn't have to figure out what to eat when.  I also looked at food magazines and cookbooks with lots of pictures to help stimulate my interest in eating.  I also view eating perhaps differently than others---For me, eating healthy foods is nutrition and fuel for my body and my contribution/participation in my healing process.  I don't eat foods as a source of comfort.  Make sure while you are on chemo that you avoid eating your favorite foods so they can stay your favorite foods after you finish chemo.  My taste buds always went on vacation for about a week starting a few days after chemo.  I know that it is not easy to want to eat but it is important that you do.  Eating 5-6 small meals a day will keep your tummy happy and may help you avoid the nausea.  Also the ant-nausea meds need to be taken with food so one doesn't get nausea just from taking the meds on an empty stomach.  Keep hydrated with water/juices/gatorade to help flush the chemo through your body.  You can also eat popsicles, watermelon and grapes to help with the fluid intake.

For me, I had 48 hours of feeling okay after my chemo.  That meant I could go do errands, go shopping, go to the grocery store, cook dinner and short felt normal.  I had chemo on Tuesdays; 2 good days (Wednesday & Thursday) and Friday I would start to not feel well.  I rested on Fridays, Saturdays and Sundays and just took it easy.  the following week was the week I would be in nadir ( lowest white cell count point) and would try to stay away from large crowds of people.  That didn't mean that I didn't get out of the house but rather I would be careful about being in close confined places where there were a lot of people, avoided sick people and kids while shopping, etc.

Hope this little glimpse of my time in chemoland helps.  HUGS to you.  Wishing minimal side effects to you and easy times in the Big Girl Chair (aka BGC). 

Maddie57

Hi Ladies, sorry I have only just found this thread, and don't have time today to go through it all, so please forgive me if someone has mentioned this before. Several of you have mentioned getting thrush. I also got terrible thrush 5 days after my first treatment. My tongue, nose and backside were bleeding. I couldn't use toothpaste - it felt like I was using hydrochloric acid. I didn't know it was thrush - thought it was sores they mentioned in their literature. Anyway the oncologist prescibes fluconazole 50 mg capsules here to be taken a week after chemo. 1 capsule a day. For my second Taxotere chemo she told me to take it 2 days post chemo, for 2 weeks and this has worked a treat. I only got thrush right on the tip of my tongue at day 5 again, and it went after 2 days. Could use toothpaste and everything!!

stagefree

Hi everyone,

bcbarbie10- I will be having my last infusion on Friday as well, YAY!! This is the first time I am really looking forward to have it, the irony of this BC rollercoaster, and be over with chemo, for now at least. I have already started Lupron + Tamoxifen 2 weeks ago. Are you starting hormonal therapy after that? The giftbox of hot flashes&mood swings the chemopause plus menapouse has made me quite popular at home these days DH finally kindly invited me to a psychiatrist to update my meds (currently on low dose Lexapro&Xanax which apparently not working any more). So we are meeting this Dr (whose photo reminded me of Prof.Emmett from the movie back to the future) tomorrow after my bloodwork. Wish me luck for some proper dose of meds that works. I really miss my sleep from before the Tax, which was in early March! I am hopeful the meds will help with scanxiety of the coming up CT at the end of the month as well.

Good news is I have hair & eyebrows filling in quite thick! Maybe can get rid of the bandanas by New Year?  

Ebru 

laura_g

Until PAeagles' post today, I thout the "Big D" was depression. Gas pills for depression? Ooooh, that D.... Haha!



Congrats Ebru!

bcbarbie10

Yay!!! Ebru!!! You're done with taxotere!!! And yes, i think my onc is putting me on tamoxifen, im just not sure when. I still have almost a year of Herceptin, though. I just did my 7/12 weelky dose yesterday, and after that will get it every 3 weeks for 12 cycles. So looking to finish Herceptin July 2013, if all goes well, God-willing. It seems we just keep on getting from one train to the next. As somebody else mentioned, cancer is the thing that just keeps on giving. Or the elephant that took residence in your living room! But hopefully, we will all get better, and stronger physically, spiritually, psychologically. Kick this elephant inch by inch out of our lives! Thinking about reuniting with my shrink, too.



Jeanieb, it does feel like near-death, but it will get better, will take its time first though. One time, day 4 post tx, i volunteered to stay home after dinner while the family went to the movies. I really thought i would die while they were watching The Avengers! Couldnt lift a finger, drenched in sweat from the hot flashes, extremely exhausted, with shortness of breath. I didnt want to cry bec that would make breathing more difficult. I exactly knew how dying will at last bring comfort. This was when i asked my onc if he could stop giving me taxotere. Hence, he lessened the dose. But look at me now, even contemplating on getting back on the full dose! It can be done, just know what to expect and you'll sail along better.



Decadron should also be taken with Nexium or any drug that will cushion its effect on your stomach. Melrose is right, must be taken after meals. Take whatever they prescribe us, we have enough se's to deal with as it is.

not

Just a heads up. Don't throw anything away!

On a few good days I thought I'd clear out clutter and I just figured out I threw away our cars pink slips (owner registrations) and gave all my good books, and $100 computer part, to the goodwill. 

I thought I was doing fine.  

jeanieb2

bcbarbie10 - I know just how you felt.  I have not been well since Sunday and thought it would get better.  The Big D started Monday and did not get better, it helped some with Imodium but started again the next day so continued on Imodium yet today, drank as much water as I could stand, no appetite and today I went for blood counts. They were fine but I could hardly stand, was not quite with it so I asked to talk to a nurse.  She had me see the PA, the onco was gone and I have seen Katie a lot so was comfortable with her.  My blood pressure was 159 over 95, I always run 120 over 80.  They could see I was dehydrated and was running a low grade temp, I had lost 4 pounds in a week, which is OK I could stand to lose 20 pounds anyway.   Katie said unfortunately I was one that is very sensitive to taxotere and the onco would probably have to decrease the dose quite a bit next time or switch me altogether.  There are to many other ones to try that will work, she did say if this was the only option we would work to get me through it but did not feel it would be worth it so we shall see what the onco says next week.  They gave me a liter of fluid, two anti-nausea medications and some decadron.  When I left I told my husband I finally felt like I could eat and I even walked to the car in the parking lot and not just to the door of the hospital, so that was saying something.  I have to call them in the morning and let them know if I feel better and if I am not feeling up to par they want to give me more fluids tomorrow.  I asked how long these effects should last and they thought within the next few days it should be letting up and getting out of my system to be more tolerable.  My question on this is did you eventually get around to being able to handle the full dose and did the lower dose make you feel so miserable and did it shrink the tumors?  I asked if it would be as effective and she said it can be, but with so many others to try she kind of thought he would change the medication.  I have gone to this onco, well since I had BC 20 years ago so I have been with him a long time and he is one that believes in quality of life as well as preserving your life so I am thankful for that.  I even cried when I was talking to the nurse today and I just do not do that, I think I can handle it all without any problems.  I told her I was sorry and she said that is what she is there for but I said, yes but there are so many more people worse off than I am and I should not be like this.  My DH asked Katie if there was something for my mood swings, I thought it was him, couldn't be me right?  Well she said to take my Xanax as needed and not to hesitate taking it.  I figured I did not need it but think I will take her advice and just take it when I feel I may need it.  I am feeling better tonight and think the fluids helped.

Yay!!! to Stagefree and bcbarbie10 on your last treatment, I hope it goes well.  I will be doing the happy dance for you.

It helps to be able to get on here and talk about it to people that understand where you are coming from and I thank all of you for listening to me carry on. 

bcbarbie10

Jeanieb, xanax works. Dont hesitate to take it once in a while. I have meltdowns every now and then and it sure feels good to cry. However, i try to keep it private nowadays as much as i can. Everybody in the family is carrying his/her own burden due to this illness and i dont want to add any more to that by being a cry-baby in front of them. Privately, though, im the biggest cry-baby i know!



The decreased dose, by 20%, decreased the se's by 50% for me. Fortunately for me, though, i am NED. So, there's no way of measuring if it's not working. My onc says we started out with the maximum dose anyway so it's ok to decrease since i already was on the "cell kill" dose from the start. I will ask him again if ok to stay on this dose or more benefits if i go with the full dose once more. I had two 100mgs. and one 80mg, that's three cycles. The fourth will be my last one.



Believe us when we say it will get better. Maybe you just needed more premedications. Discuss all your concerns and options with your onc. Hang on.

stagefree

jeanieb, thanks! I just returned from my last Tax infusion (for now at least). It feels great, hope I can pass this week without too much SE's..I had started my treatment with Tax (120mg) + Xeloda, actually, but I was hospitalised due to severe SE's to Xeloda, on just the third day. Onc had to cut it off my treatment. That week I also experienced severe insomnia, so the hospital's neurologist suggested I started on Lexapro & Xanax, baby doses. It really helped. The first two nights after infusion I still struggled to sleep, but I believe it was mainly from the steroids & Zofran. With my seventh Tax infusion, I started Tamoxifen & Lupron which brought along not only hot flashes (as if I needed any more of those, having already some with chemopause!), insomnia again & anxiety. Sooo, yesterday I visited a psychiatrist to rearrange my doses of these. He commented that the doses I had were in fact almost correct, but made a small revision that I took one dose of Xanax in the morning, one at night everyday if wanted real effect. He stressed under the fact the family of drugs like Xanax were not like painkillers, should be used regularly. I will comment on the results in a month, whether it works for me. Please FORCE yourself to eat, trust me none of us have appetite after infusion, but we need the nutrition to get the strength to keep the fight on! At some point, I had the photo album open in front of me and had each bite of food for the sake of my loved ones staring at me from it:)

bcbarbie10-I also believe in letting it out, the shower is mostly my stage for that! I cry on and on until feel no more tears are left. It feels GOOD afterwards. The pscyh also said I am supposed to live my feelings, not act the 'strong woman'. Actually I thought I wasn't doing it, but there must be a reason he said it. Anyway, I met a woman at infusion center having herceptin, she was such a lovely person. That is also a long treatment, hope doesn't have much SE's on you. Congrats on your last Tax infusion. 

not-chemobrain all right. Yesterday DH took me for my doc appointment, bloodwork & scans. Leaving the appointment, we took the elevator to the bloodcenter floor. Stepping out I asked him 'why are we here?', I totally forgot about it. And it is not the entire story. After bloodwork, DH started walking the other end of the hall. He announced he was taking me to the film (meaning also movies in Turkish). I replied thinking we were leaving the hospital this time 'which one?' !!!!!  

laura_g-thanks

Ebru 

  

stagefree

Hi Robo.. Thanks. Still feel a bit OK thanks to steroids. I really hope I can make it, maybe the psychology of having it over for now will get me on my feet sooner this time will let you know. I hope you have a great holiday over here, excited for you!

love & hugs, Ebru 

jeanieb2

stagefree - It sounds like you had a very rough start to this stuff, you certainly are a strong person, I hope it gets better all the time and things can get easier.  Thanks for the info on the Xanax also, plus the others you are taking, they did mention those to me but said they take several weeks to take effect and Xanax is as needed so to try that first.  You made me smile with the chemobrain thing, I kind of feel that way and when I talk I wonder if I am making sense to people

bcbarbie10 - I did not think to ask how many mgs of taxotere they gave me, I am sure they said but was kind of in a daze and could not remember everything they gave that day.  As for the Xanax as I told stagefree I am going to take it, the PA told me to take one in the morning and evening or more if I need it but we think that will do for now and if not then there are other things to take.  I hope they can find some other chemo that works as effectively as this one that I can tolerate more easily.  I ended up going again for another liter of fluids yesterday also, it helped some but not as much as the day before, I was more tired yesterday.  I woke up at 4AM and just layed in bed and dozed off and on until 7:30 then got up but did not have a chance to lay down again before I went in the afternoon for the fluids, did not get back home until 5 PM so I was very tired and I think that is why I did not bounce as much as the first day.

 Has anyone had any issues with the decadron?  I got it with the taxotere on Thursday, September 6, on Saturday I woke up with a red face and neck so I called the oncos office and another doctor called me back told me to take benadryl, that this can happen from the taxotere so I did and it helped.  When I went for the fluids on Thursday they were going to give me 20 mg of Decadron but I said I thought that may be to much so they just gave me 5 and that did not bother me, I had to go for another liter of fluids yesterday and they gave me 5 more decadron, this morning I woke up with the red face and neck.  Could that be kind of an allergic reaction to the decadron do you think?  I will ask the oncos office when I go again but was just wondering if anyone else has had this reaction to it.  I am suppose to take it in pill for the day before, and the day after the next chemo on September  27.

SpecialK

jeanieb - I got the red face from Decadron also - usually went away within 24 hours.  I had Benadryl IV in my pre-meds and it did not prevent the red and blotchy face, but it always went away.  With your Taxotere dosing it is done by body mass, that is why they weigh you prior to each tx.  They dose you by appropriate strength your MO has ordered by height times weight, so don't go by anyone else's dosing as a comparison.  Can they possibly give you fluids after each tx every time?  Some people just need them, especially if they are prone to the Big D.  I continued the Big D when I moved on to Herceptin alone and one of the onc nurses recommended taking a probiotic and this helped tremendously.  I have stayed on it and find it to be very helpful as I have always had GI issues since a surgery in '95 to form a new gastro-esophageal junction.  I found the BRAT diet helpful during chemo - bananas, rice, apples (applesauce) and toast, and also maybe some greek yogurt for protein and live cultures for digestion.  If your hemoglobin is dropping at all you should try to increase your protein intake if you can, I know it is hard, but you should aim for 100g of protein.  Fortified Cream of Wheat is a good source but easy on the gut.  Good luck!

not

Hi Jeanie,

I was told by ladies who did this years ago that the decadron causes bright red face/chest, or flushing, and not to worry about it, so it doesn't worry me, but I'm wondering if it causes other worse SEs.

I asked the onc and he said he'd lower it next time, but I'm not sure about what SEs it's supposed to help from the chemo and if it's worth lowering it!

Anyone else know?

[[[[[hugs]]]]] Gina 

SpecialK

not - Decadron is an anti-inflammatory that helps stop allergic reaction and also controls swelling that can happen with Taxotere.