vaccine Mayo clinic rochester

purple32

http://minnesota.publicradio.org/display/web/2011/08/17/rochester-mayo-clinic-approved-for-cancer-vaccine-trial/

Anyone live in Rochester ?

Call 1 507 538 7623 for more info.

jenrio

This is the paper I found:

http://jco.ascopubs.org/content/24/26/4254.full.pdf

It goes into the peptide vaccine's composition and the folate receptor target is also expressed in small mounts in kidneys.   So people with autoimmune problems or kidney problems may need to be careful (excluded in the clinical trial).    

Overall vaccines tend to have low toxicities so hope this trial would recruit easily. 

thanks for sharing.

Another strategy that can target folate-receptor alpha is similar to TDM-1.  Conjugate strategy:

http://www.springerlink.com/content/yv05130861863525/ 

A lot of work needs to go into how to shuttle the chemo through the receptor-binding into the cancer cells, and unload the chemo once inside.