High KI67

voraciousreader

No, Dancetrancer. What the researchers were trying to understand was why there was a descrepency with those low grade tumors that you would think would have low OncotypeDx scores... But instead had high scores. What they're saying is that there are STILL more variables that affect proliferation. In this situation they were able to identify the cell stroma and inflammation playing a role in proliferation that should be further noted and evaluated in low grade tumors.





What I think is important to note is that there are MANY tumor characteristics that ultimately tell us how aggressive a tumor is. And just when we think we know all the pieces to the puzzle... Then the researchers say, "Hold on a minute... Here's something else."

dancetrancer

Thanks VR - that's what I had initially thought, but the way they wrote that was very confusing to me.  That is indeed very fascinating.    So many things we still do not know about this beast!  

JaneB1

Like Heidi, I was treated very recently at Sloan. My post-mastectomy pathology report has no Ki67 number. When I asked my onco about it, she said Sloan stopped using Ki67 for treatment purposes in the late 1990s because they determined it was not a reliable independent prognostic indicator. She said it remains popular in Europe and is used there.

jenlee

My ki67 was high, I think over 70%. After chemo, I first had a lumpectomy. The lump had no invasive cancer remaining, only some DCIS, which was much more highly ER+ than the core biopsies taken to prior to chemo. As one of the previous posters said, it all depends on what part of the tumor the core biopsy is sampling. But still confusing to me.