BKM120 P13K trial for recurrence

gemdancer

Hi all,

I'm based in UK. Diag 2008, chemo, mast, rads, herceptin, tamoxifen. HER2 pos and ER pos. Recurrence neck node 2010. Switched to zoladex and given capacetabine for 7 mths. Couldn't tolerate lapatinib. Second recurrence in 2 neck nodes just diagnosed, whilst on Herceptin. Onc has given me prognosis of 2-3 yrs (have no other progression), which shocked me.  Says herceptin and chmo have failed. Have been offered (if I pass the screening) clinical trial: BKM120 in patients who have relapsed with herceptin. Would be herceptin and BKM120. Think latter is some kind of protein (P13K)  inhibitor. It looks a bit daunting. Weighing this up against going back on chemo. It's one or the other. Anyone had any experience over here?  Have 6 year old and want to make right choices!!!!

Thanks,

Gx

BarbaraR0305

i guess no one has had any experience with this.

i've been invited to join this study... tamox and femarra failed... started on fazlodex... study starts in a couple weeks... my research shows some success with it... and the data gathered would be helpful to everyone... lord knows, though, i'm scared for me...

orange1

Hi Barbara,

I am so sorry about your recurrence. 

I don't know anything about the particular compound that you posted about, but I do know since you haven't been in a clinical trial yet, and you haven't used up all your different chemo possibilities - you're still early on.  If at all possible, if you want to do a clinical trial, do a phase 3 trial (best) or possibly a phase 2 trial.  The reason is is that drugs in Phase 3 have already shown some evidence that they work in a Phase 2 trial, so you have a much better chance that the therapy will be helpful.  A drug in a phase 2 trial ususally doesn't have much evidence that it works yet- that is what they are trying to determine - also what dose/dosing schedule, etc.  A phase 1 trials is just trying to see if the drug is well tolerated (safety trial) and has no evidence of efficacy in humans yet.  Phase I cancer trials should only enroll women that have exhausted all other options.  

If you are interested in participating in a Phase 3 trial, and your onc doesn't offer one - ask him about trials being offered at other centers.  Otherwise you can look them up yourself at clinicaltrials.gov .  Do you have a friend in tbe medical field who can help you sort it all out?

Best wishes to you.

gemdancer

I didn't get on the trial, as my neck lump (although easy to feel and clear on ultrasound) did not show up on MRI or ct scan. Needed to show to be measurable. Back on chemo now. Thanks for the info about clinical trials though- very useful! Gx