Genelex DNA Medication Sensitivity Testing

TooManyCocktails

Has anyone else heard of this or  had this test done?

When I went to see my psychiatrist today, she ordered this test.  I have no idea how much it costs.  Anyway, I have always been sensitive to medications especially psych meds.  I usually couldn't get past a child's dose on antidepressants. 

It'll be interesting to see what the test shows.

http://www.healthanddna.com/drug-safety-dna-testing/dna-drug-reaction-testing.html

phoenixrising

Hi, I had it done and by Genelex a few years ago when I was having problems with Tamoxifen.  It cost me about $300.  I think it was a good move to have you checked esp with psych meds....a pharmacist told me that smoking/nicotine makes a difference in the metabolism of those meds....that just came to mind so I thought I'd add it.  Good luck to you.  I'm sure it'll be nice to get on something that works for you.

TooManyCocktails

The test showed that I was an intermediate metabolizer of certain drugs.  My pyschiatrist really felt that I should no longer take Nortriptyline due to this; so I stopped taking it a few days ago.  It hasn't been easy.  I'm having laryngospasm/s and peripheral neuropathy.  I have pain meds; but they don't seem to work on peripheral neuropathy as well.  I can't take Gabapentin because I'm allergic to it.

Now, I know why I was sensitive to so many SSRI's.

Here's a little info about the testing:

Cytochrome P450 2D6 Genotyping

 Web Seminar:
Pharmacogenetics in the Practice of Medicine

CYP2D6 (cytochrome P450 2D6) acts on one-fourth of all
prescription drugs, including the selective serotonin reuptake inhibitors
(SSRI), tricylic antidepressants (TCA), betablockers, opiates, neuroleptics,
antiarrhythmics and a variety of toxic plant substances. Some 7-14% of the population
has a slow acting form of this enzyme and 7% a super-fast acting form.
Thirty-five percent are carriers of a non-functional CYP2D6 allele, especially
elevating the risk of adverse drug reactions when these individuals are taking
multiple drugs. Drugs that CYP2D6 metabolizes include Prozac, Zoloft, Paxil,
Effexor, Hydrocodone, Amitriptyline, Claritin, Cyclobenzaprine, Haldol,
Metoprolol, Rythmol, Tagamet, Tamoxifen, and the over-the-counter
diphenylhydramine drugs, Allegra, Dytuss, and Tusstat. CYP2D6 is responsible
for activating the prodrugs codeine and other opioids into their active forms.
The analgesic activity of the drugs is therefore reduced or absent in CYP2D6
poor metabolizers. Refer to list for substrates, inhibitors and inducers of
CYP2D6.

Genelex offers improved detection rates using an extended
Cytochrome P-450 2D6 DNA mutation panel. This test identifies 17 small
nucleotide variants and two gene rearrangements in PCR-multiplex format,
providing increased sensitivity and quality performance. This CYP2D6 Mutation
Detection Panel is the most extensive on the market and covers over 93-97% of
poor metabolizer phenotypes. Analytical specificity and sensitivity for
detection of these mutations are >99%.

Indication for Testing

 For individuals with
a personal or family history of adverse drug reactions to medications
metabolized by CYP2D6. Confirm presence
of genotypes that affect the metabolism of drugs such as Tamoxifen that are
metabolized by CYP2D6.

 Edited to add... I forgot to add the source:

http://www.healthanddna.com/healthcare-professional/p450-2d6-genotyping.html