Zometa - Latest News out of San Antonio Meeting

voraciousreader · December 2010

Zometa Didn't Prevent Breast Cancer From Coming Back By Charlene Laino
WebMD Health News Reviewed by Laura J. Martin, MD 60-ish woman

Dec. 9, 2010 (San Antonio) -- The bone-building drug Zometa does not appear to prevent breast cancer from coming back in most women, researchers report.

Adding Zometa to standard therapy, usually chemotherapy, also did not extend lives, according to results of the study of more than 3,000 women.

In women who were at least five years past menopause, however, the addition of Zometa improved overall survival rates by 29%, compared with standard treatment alone.

"This wasn't a small subgroup; 1,101 women fell into the category," says Robert Coleman, MD, professor of medical oncology at the University of Sheffield in England.

"The benefit was so great we don't think it's a chance finding," he tells WebMD.
Still, the results of a subgroup analysis cannot be considered conclusive, Coleman says.

Based on the findings, Novartis Pharmaceuticals, which makes the drug and funded the study, will withdraw U.S. and European applications for approval of Zometa to prevent breast cancer recurrences.

Coleman presented findings of the study, dubbed AZURE, at the San Antonio Breast Cancer Symposium.

A Visual Guide to Breast Cancer

Earlier Studies Raise Hopes

Zometa, given as an infusion, is a member of a class of drugs called bisphosphonates that help maintain bone strength.

Animal and lab research suggests that bisphosphonates may fight breast cancer in a number of ways -- by directly killing tumor cells, by cutting off their blood supply, or by stimulating the immune system to mount an attack against the tumor, says Rowan Chlebowski, MD, PhD, a medical oncologist at Harbor-University of California, Los Angeles Medical Center.

The new research builds on a study presented at the 2008 breast cancer meeting showing that Zometa appears to prevent breast cancer from coming back.

Then, last year, Chlebowski presented an analysis of data on more than 150,000 women that showed that there were 31% fewer cases of breast cancer among women who took bisphosphonate pills than among women who didn't.

Zometa Does Not Appear to Prevent Breast Cancer Relapses

The new five-year study involved 3,360 patients with breast cancer that had spread to the lymph nodes.

A total of 404 women given Zometa plus standard therapy and 403 of those given standard treatment alone had a recurrence, developed a new cancer, or died before they had a recurrence.

Altogether, 243 women on Zometa and 276 on standard treatment alone died, a difference so small it could be due to chance.

Twenty-six women on Zometa had confirmed or suspected cases of osteonecrosis of the jaw, a side effect of bisphosphonates that causes the jawbone to decay.

Routine Use of Zometa for Breast Cancer Treatment Not Warranted

Since only women who were well into menopause appeared to benefit from the drug, Coleman says he suspects it works best in an environment of little or no estrogen.

Commenting on the findings, Sharon Giordano, MD, MPH, of the University of Texas M.D. Anderson Cancer Center in Houston, says the scientific community has been waiting to hear these results.

The bottom line, she tells WebMD, is that the routine use of Zometa to prevent breast cancer recurrence is not warranted at this time.

As for its apparent benefit in postmenopausal women, Giordano says, "Those findings are very intriguing, but not definitive."

Four trials are under way that should better define bisphosphonates' role in breast cancer prevention, she says.

The results do not affect Zometa and other bisphosphonates' "important role in treating bone loss among women with breast cancer," Giordano says.

Zometa is approved for the reduction or delay of bone complications across a broad range of cancers that have spread to the bone and multiple myeloma. It costs about $1,000 an infusion.

This study was presented at a medical conference. The findings should be considered preliminary as they have not yet undergone the "peer review" process, in which outside experts scrutinize the data prior to publication in a medical journal.

Top Picks

breast cancer newsletter

There are new weapons in the fight against breast cancer. Know them. Sign up for the WebMD Breast Cancer newsletter and stay informed.

View Article Sources Sources

SOURCES:

San Antonio Breast Cancer Symposium, San Antonio, Dec. 8-12, 2010.

Robert Coleman, MD, professor of medical oncology, University of Sheffield, England; consultant, Novartis Pharmaceuticals.

Rowan Chlebowski, MD, PhD, Harbor-University of California, Los Angeles Medical Center.

Sharon Giordano, MD, MPH, University of Texas M.D. Anderson Cancer Center, Houston.

Breast Cancer Guide 1 Overview & Facts 2 Symptoms & Types 3 Diagnosis & Tests 4 Treatment & Care 5 Living & Managing 6 Support & Resources Related to Breast Cancer

Common Treatments for Breast Cancer

Find Oncologists:

Enter Location: e.g 60607 or Chicago, IL or IL Physician Directory Terms

Hot Topics in Breast Cancer

Questions About Breast Cancer? Renowned oncologist Philomena McAndrew, MD, has answers. Close

WebMD Answers

More breast cancer questions? Ask Your Question

Choosing Mastectomy

A study reveals why a high number of women with breast cancer still prefer to have the entire breast surgically removed instead of just the tumor.

Watch Video: Choosing Mastectomy (opens in a new window)

Save 2nd Base

Activists use humor as tool to fight breast cancer.

Watch Video: Save 2nd Base (opens in a new window)

Detecting Stage Zero Breast Cancer

Imaging Technology Advancement is Helping Doctors Find Early, Highly Treatable, Breast Cancer at What's Called Stage Zero.

Watch Video: Detecting Stage Zero Breast Cancer (opens in a new window)

Breast Cancer Side Effects

Lymphedema causes painful swelling in the arm near the affected breast. A new study helps patients cope with the problem.

Watch Video: Breast Cancer Side Effects (opens in a new window)

Breast Reconstruction Options

A new type of breast reconstruction offers more choices for breast cancer survivors. It gives doctors added flexibility to create the most natural looking replacement.

Watch Video: Breast Reconstruction Options (opens in a new window)

video library >

Zometa - Latest News out of San Antonio Meeting

Categories