HELP......NEED SOME OPINIONS AND FEEDBAC

mhand

Dear Sir /Madam:

I am a Chinese,I have done the breast cancer operation in Cancer Institute and Hospital. Chinese Academy of Medical Sciences in Beijing, China. The analysis of cancer results were as follows:

Aged 48, menses paused for one and a half years at the age of 46, then menses reappeared. Finished left breast modified radical mastectomy operation on 23.Aug.2010.



307 Hospital: Intraductal carcinoma II，multifocal infiltration with complication (max diameter in infiltration area <1mm). Findings of vascular invasion remained obscure. ER(-)PR(-)HER-2 (Intraductal carcinoma+++, infiltration area++)KI-67(70%) FISH Results：positive (HER2 amplification, Intraductal carcinoma and infiltration area amplification)
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Cancer Institute and Hospital. Chinese Academy of Medical Sciences: High grade breast carcinoma in situ, CK5|6 and P63 Focal myoepithelium loss, suspected early invasive carcinoma. Tumor without nipple, skins and pectoral fascia involvement. Breast adenosis changes in surrounding galactophore. No Metastases of the Breast Carcinoma in Axillary Lymph node（0|10）。ER(-)



Medication taking:

Tamoxifen citrate tablets （take a pill twice a day）

Selenious yeast tablets （take 2 pills twice a day）



Question:

1. Do I need to do targeted therapy? Can targeted therapy help me?

2. ER/PR-negative, What effect will endocrine medicine have on cancer treatment? How to ease side effect?

BarbaraA

Wait, you are ER/PR negative and are taking Tamoxifen? That does not make sense to me.

Beesie

If I am interpreting your pathology report correctly, you had high grade DCIS with a 1mm microinvasion.  That's the same as me.  After my mastectomy, I required no other treatment.  I was offered Tamoxifen as a protection for my remaining breast, but I opted to not take it (and my oncologist against recommended against it).

Normally Tamoxifen would be prescribed only to those who have tumors that are ER+/PR+ but in your case, you really don't need Tamoxifen (or any other treatment) to address the cancer that you had.  After your mastectomy, your risk of recurrence is only 1% - 2% and Tamoxifen provides little benefit to someone with such a low recurrence risk.  In any case, since your cancer was ER-/PR-, Tamoxifen wouldn't be effective in reducing your recurrence risk anyway. So if you take Tamoxifen, it's only to protect your remaining breast.  If you were to get breast cancer again, it would not necessarily have the same hormonal status as your previous diagnosis; in other words, it could be ER+/PR+. So taking Tamoxifen can be effective at reducing your future risk of a new breast cancer.  Still, it certainly is optional - it's not something that you need to take to address your current cancer.