CyP2D6 Testing, and then what.....

Mamita49

My onc is giving me the CYP2D6 metabolizing test. But then he said, Ok, you can have it, but what does it good to you ?

i dont know, you should know.........

What if I am a poor metabolizer, what then. I surely will NOT give-up the Tamoxofin. I still believe in it so much, but what if the test shows bad results, what difference does it make in taking the drug ????

Best

Carol 

Anonymous

I had the test and it showed that I was an intermediate.  My onc was not too excited by it.  What she really focused on was the fact that I had hot flashes from the tamoxifen.  She thought that was the most reliable test of my tamoxifen uptake.  I am not convinced as I am also on Zoladex but being an intermediate is not bad as long as i dont take other CYP2D6 drugs.  I might get switched to an AI once ovaries are out and I recover from recon.  I get the impression that she really wants me on tamox first before an AI.   

karen_in_nj

I was planning to ask my oncologist to do the test when I see her next month. If it shows that I'm a poor metabolizer then I will push to have my ovaries removed so that I can go on an AI instead. I started taking tamoxifen about a week ago and so far not a single side effect, which of course is worrying me.

KerryMac

Actually, I have read that intermediate metabolisers get the most hot flashes, that extensive and poor get the least.So lack of hot flashes is not necessarily a bad thing.

Carol - if you are a poor metaboliser, I would get your Ovaries removed and take an AI. Just my opinion. 

karen_in_nj

Thanks KerryMac, that is so good to hear. It seems these days that I look for anything to worry about!

Mamita49

Thanks Kerry,

You bet................ 

Mamita49

what is the real wording in your test, like i posted it somewhere else it said in mine only no gene mutation, but I am not sure what it means really.