Anyone ER-/PR+/Her2- ?

RobinTatas

Recently diagnosed and this is my first time on a forum.  It's mind-blowing to read the multitude of posts.  You all sound so informed and in command.  I want some of y'all's Mojo!!

I'm ER negative/PR+/Her2-.  Oncologist said that was "rare," but I was so busy taking notes that I didn't ask enough questions.  Before my next appt. I'd love to hear from someone else in the same boat.  I couldn't find anyone in a quick scan of profiles.

Overview: Things are moving really fast.  Mammogram, re-check, ultrasound, biopsy and pathology report all done in the same day. (Amazing speed, from what I'm reading from other forum scribes.)  CAT, MRI and PET/CAT all done in week one, and game plan in place by week two.   Should be starting chemo next Thursday.  (Delayed a week by another illness that landed me in the hospital for 3 days.) 

I don't have a copy of pathology report, but Dr. said it's Stage IIb, 2 primary lumps linked by other little lumps (?) that the team are calling one 5 cm lump.  Chemo will be FEC100 every 3 weeks for 3 or 4 cycles, then weekly for 12 weeks.   First surgery will remove left ("bad') breast, then on hormone therapy, followed in six months by removal of right breast (which has two benign lumps) with reconstruction.   Does that sound familiar to anyone? 

Honestly, I'm not much of a "joiner."   But this thing is overwhelming, and I hope to contribute as well as gain from joining this forum.   Anything you can share will be appreciated.   

TenderIsOurMight

Robin, I looked at your post last night, and while I'm ER+/PR+ did have a thought or two.

Since the biopsy lending the ER-/PR+ status was the initial and apparently only biopsy done, and ER-/PR+ is indeed rare, might you talk with your oncologists about a) accuracy of hormone receptors on small amount of tissue b) biopsy results discordance rate with subsequent surgery (  First surgery will remove left ("bad') breast) hormone results and c) differing techniques to discern the estrogen receptor given the IHC (immunohistochemical) technique was negative.

You have lots of time to further investigate this, since you're having neoadjuvent therapy. Still, it does seem wise to ensure you're truly ER-, as typically the presence of the progesterone receptor (PR) depends on estrogen's presence.

Good luck,

Tender