100% progesterone fed

idaho

Anyone else have 100% progesterone fed cancer? It is also 80% estrogen fed.  So, I am taking tamoxifen to block the estrogen- and my onc. cannot tell me what to do to block the progesterone!  He looked like me like a had grown another head! Any ideas out there?  Why hasn't this been researched?  Thanx in advance for the help!  Tami

LRM216

Unfortunately, I am just the opposite and had 0% readings for my ER and PR, leaving me wonderfully triple neg (ugh!).  I still can't understand this whole thing as I always had sore breasts during each period, and a gruesome menopause with hot flashes all the time, and night sweats that would send me up the wall.  Now, all that's caused by hormones - so where the heck did they all go?  I'll never figure it out.  Hope you get someone with similar receptors results so your questions will be answered. 

Linda

soprano

Hello Idaho!  Please someone correct me if I'm wrong, but I believe that Tamoxifen or AIs work for both ER and PR receptor positive tumors.  All the best to you! (edit- I read a bunch of stuff on line which supports this before I posted. There's a lot of stuff to read out there)

Soprano

Regawhatever

I'm in your boat, too. Mine is 100% estrogen and 99% progesterone receptive. I haven't been to an oncologist yet, but from what I've heard, the high percentages can be a good thing. Did you have to have chemo?

-Tricia

Mamita49

Mine are both ER+85% and PR+ 85%.

Now does that mean something less, or bad than being a full 100 or 99%. I have the feeling the 85% means something not so good.

Any input 

bcinfo

As far as I know from reading, it is good to be both ER+ and PR+, and I think 85% is a high number, Mamita.  I don't know if there is really a difference between 85% and 100%, for instance. Some tumors are very weakly ER+ or PR+ (i.e., like 5%), and that would be what you would be looking at if you had a low number, not 85%.  I was also wondering about whether the PR+ is treated by tamox or AI, and was going to look it up. One thing I've noted, though, is that a number of the tumors that progressed to Stage IV (see Roll Call section) are ER+/PR- which makes me think that somehow being ER+/PR- might be a very different type than ER+/PR+, and not in a positive way.  I think I read something recently about PR receptivity and BC along these lines but I can't find it. If I do, I'll post again. 

Dawnbelle

I can explain that bcinfo.

ER positive cancers do not always respond to estrogen by letting it signal them to grow.

When they do, they normally will produce a PR positive. Being ER positive & PR positive means that you will have a better chance of responding to hormonal treatment.

cp418

ER+100%, PR+100%, Her2-negative

auriga

Another lady posted this link on a different thread. I found it to be very interesting regarding how well you will respond to hormone thereapy. It looks like being both ER and PR positve is the most common and also the most responsive to hormone therapy.

http://www.breastcancer.org/treatment/hormonal/what_is_it/hormone_role.jsp

BlessedOne2

ER+ 59%, PR+61% and HERs/neu positive 

LRM216

Aw-  Jo-5, LOL!  Being triple neg, I love your diplomacy and I thank you for it!

Linda