ER/PR Positive doesn't mean you will have better prognosis?

hlya

Somebody show me a research on paper saying that some research don't agree that "ER/PR positive would have better prognosis", those scientists said in some ER/PR positive cases, the "Tumor Angiogenesis Factors" and "Hypoxia-inducible Factor" are also relatively high, it will make the cancer cells much easier to go to blood under Hypoxia environment.



Did anybody see something similar?

hlya

Hi, Brenda,



Yeah, I agree with you. Can you get Als under family doctor's prescription?



BTW how old are you when you were dx?

CherylAnn

My mom was diagnosed 4 years ago at age 70 with stage IIA, negative sentinel nodes, clean margins.  She had radiation and is taking arimidex. Her onc just told her she will be on for the next 20 years. Originally he told her five years but new studies prove different. 

cp418

I wonder about rotation among the hormone treatments to some how prevent resistance to a particular drug.

hlya

Hi, Joann,

 Glad to see you here.

I am also thinking that more people used Tamoxifen, the more chance that virus will  build up the resistance (like antibotic drugs can't be used too much),  or they will mutate to differnet pattern.

spar2

After reading this, now I am getting scared.  I have been on Arimidex for 5 years.  this is my first week off.  I understood the odds are the same if you keep on taking it or if you stop. So am going to have to do some research.  I guess we all will be looking over our shoulder for the rest of our lives which is kind of depressing.  But I think I will decide to keep my joy anyway.

BWorrier

spar2:

This is the key nature of this disease.  You will never get rid of it unless you could totally forget it and move on, otherwise it will be with you throughout the rest of your whole life either physically or mentally, or both!

Anonymous

I guess my situation really was favorable: at the age of 45, chemo put me into menopause. Technically, I "should have" begun an AI. But my Onc said that because I was newly menopausal, I should go on Tamoxifen for 5 years and then switch... thus allowing me several additional years of protection. AND - he said that by then (5 yrs of my Tamox will expire in Feb of 2011) perhaps something better will be available. Maybe even for those whose 5 yrs of AI's have expired.

spar - Have you looked into the possibility of you continuing with 13C? I am researching it to see if I should switch to it because it's a natural alternative to synthetic hormone theatment.

I'm trying to find a Dr who has FAB knowledge of balancing each woman's individual hormone levels - instead of one who simply treats every woman the same...not too many good ones out there. Usually a compound pharmacy knows the names of Drs who prescribe 13C...that's where I'm starting to get names from.

hrf

What is 13C?

Hood1980

What is FAB?

dlb823

I3C is short for Indole-3-Carbinol.  It's the active ingredient in cruciferous vegetables -- the component that makes broccoli, caulifower, brussel sprouts, cabbage, etc., so good for us, and known to protect us from developing some types of cancer. I3C acts as an anti-estrogen or estrogen balancer, and it''s available in any good health food store.

There is also a similar supplement called DIM (Diindolylmethane) that some women take instead of 13C.  I'm not sure which is really preferable, and I suspect some of it has to do with the composition (which affects absorption) and quality of the brand you choose.          Deanna

roselle_purol

My mom was diagnosed stage IIa, ER-/PR+, Her2-, 10/10 lymphnodes are negative for carcinoma, and she was also diagnosed with type II Diabetes Mellitus. I just want to know, do you have any idea on the prognosis of this case?