Mucinous Carcinoma of the breast

obsolete

Hi Krystin, so sorry about your loss, & it's a crapshoot you now find yourself here. Hopefully you're healing well, and glad you made a good surgical choice, considering your family history. My experience was different, but I'm wishing you well without any further advice other than to suggest you take things slow & easy. Take care.

obsolete

Hi Krystin, so sorry about your loss, and sorry you now find yourself here. MC is a crapshoot, but I think you made the right surgical choice under your circumstances. There's never a wrong choice because everyone is different. Please take it slow & easy thru your healing process. Best wishes

obsolete

Neovascularization In Mucinous Ductal Carcinoma In Situ Suggests An Alternative Pathway For Invasion

S A Gadre et al. Histopathology. 2008

https://pubmed.ncbi.nlm.nih.gov/18983463/

Precursor Lesions Of Mucinous Carcinoma Of The Breast: Analysis Of 130 Cases

Oleksandr N Kryvenko et al. Am J Surg Pathol. 2013 Jul.

https://pubmed.ncbi.nlm.nih.gov/23759933/

obsolete

Mucinous carcinoma of the breast: Diagnosis and management of an unusually young patient

Published online 2022 Mar 2

"...in the case of mixed-type mucinous carcinoma they require more frequent chemotherapy adjuvant (31.6% vs 7.4%, P < .001), and undergo more mastectomy (32.9% vs 11.1% P < .001) than those of the pure subtype."

"The decision to treat a patient with mastectomy depends on her category..., may or may not require radiotherapy, this will depend on whether the patient has a tumor with deep margins or lymph node involvement. However, radiotherapy has NOT shown a significant difference in the overall survival of patients with mucinous carcinoma of any subtype."

"Systemic hormonal neoadjuvant treatment will depend on the characteristics of the tumor, especially aimed at locally advanced tumors."

Reported 10-year survival for pure tumors is 87%-90% and that of the mixed subtype is 54%-66%... Although the benign appearance of mucinous carcinomas on mammography can cause a delay in diagnosis, it is also true that they have a FAVORABLE PROGNOSIS, as they are low-grade, slow-growing tumors that rarely metastasize. The largest cohort of this type has shown that the prognostic factor continues to be lymph node involvement, followed by age, tumor size and having hormone receptors."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899128/

obsolete

Everybody, Praying for Peace, adequate food supplies and good health for all 🙏

(2022) "Mucinous Breast Carcinoma"

Continuing Education Activity:

"Transcriptomic studies have demonstrated that mucinous tumors are of Luminal A molecular subtype [4]. The transcriptomic features of mucinous A are distinct from those of mucinous B tumors, the latter showing a pattern of gene expression that is similar to that of neuroendocrine carcinomas [4]. Pure mucinous carcinomas harbor a low level of genetic instability and rare recurrent amplifications, and the genomic profiles of the tumor components of mixed mucinous tumors are remarkably similar to those of pure mucinous carcinomas. More than 90% of pure mucinous carcinomas are diploid, whereas only 42% of mixed mucinous carcinoma are diploid [5]."

"Typically, mucinous carcinoma is positive for estrogen and progesterone receptors [9], while androgen receptors are expressed at a low level, and HER2 is not amplified [10]. Pure and mixed mucinous carcinomas are reported to express WT [11]. Mucinous breast carcinoma expresses predominantly MUC2 and MUC6 among the family of MUC genes [12]."

"General health status: Higher prevalence of comorbidity, frailty, and cognitive decline in elderly patients are considered limiting factors when selecting treatment."

"Axillary lymph node metastases occur in 12% - 14% of the cases [19]."

"Late distant metastases may occur in pure mucinous carcinoma [21]."

"Other studies have found that tumor size is not a significant prognostic factor and does not affect survival since most tumor volume consists of mucin."

"Complications of breast mucinous carcinoma include:

-- Axillary lymph node metastases

-- Late distant metastases

-- Recurrence after surgical excision"

"After treatment of mucinous breast carcinoma, long-term follow up is necessary to detect local and distant relapse. [Level 5]"

https://www.ncbi.nlm.nih.gov/books/NBK538334/

obsolete

Mucinous Cystadenocarcinoma Of The Breast: A New Entity With Broad Differentials-a Case Report

Kanwalpreet Kaur et al. J Egypt Natl Canc Inst. 2022.

"Mucinous cystadenocarcinoma is a rare and recently described primary breast cancer with strikingly similar histomorphology to ovarian, pancreatic, and gastrointestinal counterparts... strong membranous HER2-protein expression and HER2-gene amplification ... in literature this tumor is reported to show mainly triple-negative basal type immunophenotype."

https://pubmed.ncbi.nlm.nih.gov/35224708/

obsolete

Mucinous Breast Carcinoma Metastatic to Thyroid Gland: Report of A Case Diagnosed By Fine-Needle Aspiration Cytology

"woman who had breast cancer 13 years ago was diagnosed as thyroid metastatic mucinous breast carcinoma, cellular variant with neuroendocrine differentiation. For this patient, the thyroid was the only involved site."

https://khepri-node.dev.meta-infra.org/papers/muci...

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Attention: those Mucinous patients who test high risk and/or Luminal B phenotype in assays, you may find this thread helpful...

https://community.breastcancer.org/forum/96/topics...

Rain88

Thanks for the reading, Obsolete. I am joining you in praying for PEACE, necessary supplies, heallinag and health.

BoobBoo

Hello marvelous mucinous members! Quick update on my progress. I had surgery in Seattle on 2/24/22. All went well with breast conserving surgery and 3 lymph node removal. The pure mucinous tumor was less than 10 mm across and minor in situ ductal carcinoma was discovered. My team at Seattle Cancer Care Alliance was fabulous and I was back in Anchorage on March 8. I am doing some PT and start set up for radiation tomorrow here. I will have 16 sessions and will be on an aromatase inhibitor for five years max.

Thanks for all the advice and well wishes from many of you. I went into my appointments SO much better informed and knew the right questions to ask and how to be a part of my own treatment. By the way Nordstrom has a really great supportive bra that hooks up the front that I got while in Seattle. The brand is Amoena. I bought two in Seattle and they are available in white and nude online. Better than the Fruit of the Loom cotton ones I got on Amazon. I still wear those but they are not nearly as supportive and compressive after surgery. During radiation I will probably use the Fruit of the Loom cotton ones as they are softer material.

Best to all, BooBoo!

Rain88

Booboo, I'm so happy that everything went well with your lumpectomy and that you got a good path report! Radiations will be easy and I hope you will tolerate well the AI. Thanks for the update and all the best going forward! ♥️

obsolete

Hello Canada & Alaska, best wishes for healthful healing to Boo. Friendly springtime 🌼 greetings to Rain and hoping everyone has a pleasant season. Peace 🕊️ & good intentions 🙏

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CONSTRUCTION OF A PROGNOSTIC NOMOGRAM MODEL FOR PATIENTS WITH MUCINOUS BREAST CANCER( (2022)

"... there is a lack of reports of large sample studies on MBC, which predisposes to under-treatment or over-treatment."

"Univariate analysis of the survival of 2,776 MBC patients in the modeling group revealed that the 3- and 5-year survival rates of patients were linked to their age, ethnicity, marital status, T stage, N stage, M stage, surgery, radiotherapy, and chemotherapy, but NOT to histological grade, lesion location, PR status, ER status, or HER-2 status as indicated in Table."

"... age at diagnosis is the greatest contributor to the prognosis, followed, respectively, by M stage, TNM stage, ethnicity, surgery status, and radiotherapy status. The nomogram shows that the use of radiotherapy is beneficial for patients with MBC."

"... only lymph node involvement is considered chemotherapeutic, regardless of the T stage."

"Furthermore, lymph node involvement was found to be unrelated to tumor size in one investigation."

"It has been shown that patients treated with breast-conserving surgery in stage T1-2 MBC have a better prognosis than those who undergo mastectomy, particularly in patients aged 50–79 years;"

"In the current study, a total of 2,043 (51.5%) patients received radiotherapy and 1,921 (48.4%) did not. The nomogram shows that the use of radiotherapy is beneficial for patients with MBC."

"It has been reported in the literature that the reason for the low efficacy of chemotherapy is that mucus accounts for most of the total volume in MBC cells, forming a large pool of mucin, resulting in inconsistency between clinical or imaging assessment of chemotherapy efficacy and mucinous carcinoma pathology. Despite the effective elimination of malignant cells by chemotherapy, the mucin pool remains."

https://downloads.hindawi.com/journals/jhe/2022/12...

thecargirl

Thank-you Obolete for all the information you share. This last article is really significant, I am making a copy to give to my first oncologist, he needs to be educated! My second oncologist was up to date on Pure Mucinous Breast Cancer .

franblue67

I had Mucinous carcinoma that was extracted. Now the doctor recomended the radioterapy plus Ovarian suppression combined with tamoxifen. Any expirience in not taking the Ovarian suppression and combined with tamoxifen?

sarahvancouverisland

Hey Fran. You must be pre-menopausal? I was too. I had chemo then radiotherapy, and now I'm doing ovarian suppression combined with Exemestane (so an AI rather than Tamoxifen). The side effects have been present but very manageable. The main factor for me is being unable to have children naturally, but I'd rather stay on the meds and avoid recurrence. Tough decision but that's the direction I decided on. Happy to answer any questions you may have. What is making you think of declining the ovarian suppression?