About ER、PR、HER-2

hlya

Sorry I saw everybody got these result from surgery, but it sounds too complicated to me.



Seems ER PR positive would be good for post-surgery treatment. I would like to know more about it.



Esp. to ILC, seems ER PR positive would be good for treatment, and how does it impact the recurrance? If you are ER PR positive, would the rate of reccurance be lower than negative ones?



Can somebody explain to me about HER-2? How would it affect ILC?



I read on web that actually the treatment to ILC has no difference from IDC, is that true?



Thanks.

idaho

Did you get a copy of your pathology report?  It really is not complicated.  If you are ER/PR + that just means that you can be treated with an estrogen blocker like tamoxifen.  If you are ER/PR- that just means you cannot be treated with estrogen blockers.  ER/PR + means that your cancer is fed by hormones.  I don't know the rate of recurrence for ILC for sure, but I do know that if you get rid of ER- cancer and it doesn't come back for a couple of years it probably never will come back.  HER-2 is a protein that is tested for in your pathology report.  It just lets the oncologist know how best to treat you.  I think the treatment for ILC and IDC are about the same, It all depends on your test results what the best treatment for you will be.  There will be other women post that know more than me, so keep reading!  If you don't have a copy of your path report go to the place you had your biopsy done and request a copy, then have them explain it to you.  Good luck,  Tami

hlya

Hi, Tami,



Thank you very much for the response.



I only have ultrasound, mamo and biopsy report, but the biopsy report doesn't say anything else except confirmed ILC features. Should I request for more info.? why there is not much info. in Biopsy report?



QAnna

nash

QAnna--ER/PR positive cancers tend to have a later recurrence rate than triple negative cancers, meaning they tend to come back as metastises after 10-15 years, as opposed to 2-3 years. That doesn't mean that every patient will relapse--it just means that the ER/PR+ ones have more of a tendency to metastisize after many years of disease free survival.

ILC almost never overexpresses HER2. If for some reason yours does, then you can add a drug called Herceptin to your adjuvant treatment. HER2+ tumors are more aggressive than HER2- ones.

ILC and IDC are treated the same. The oncs look at receptor status and tumor grade as opposed to clinical subtype when deciding treatment options.

After your surgery, if your nodes are negative and your tumor is ER/PR+, be sure the onc orders a test called Oncotype DX for you. It looks at the DNA of your tumor and helps the onc to determine whether you will derive a greater benefit from adjuvant hormonal treatment or from adjuvant chemo. A low score on Oncotype means you can forgo chemo and just do HT. 

You will get a lot more pathology information from your surgical path report. I posted to you over on your other thread regarding your sugery, BTW.