Anyone ever take Doxil (lilposomal doxorubicin)

gciriani

I wanted to let all who are taking Doxil know, that I have been quite successful at neutralizing the effects of the drug on hands and feet. I compounded at home ingredients similar to what's described in the study above and it worked.

I waited two weeks after the administration of the first dose of Doxil; at that point especially the feet had started peeling, and were itching like crazy. In the meantime I had searched for and bought the crucial ingredient (anti-oxidant concentrate). I mixed it with a good emollient cream, and started applying it to hand and feet mornings and evenings. In less than a week, the side effects abated. Now they are much more bearable: no itching and almost no peeling. I'm still experimenting with different emollient creams, as the base, too see if one works better than the other; however, the active ingredient is the anti-oxidant. I've also found more research validating* the remedy (my oncologist had not heard about it, so I had to dig out more info for her). The manufacturer of the original remedy used in the studies is German but they don't export it to the US because FDA approval would cost top $ for a niche product.

I would be glad to compound more for others to try.

The bad news for my wife is that, even after the second dose of Doxil the bone aches seem to be increasing; the oncologist says that she has to go through at least 3 doses before deciding if it's working or not.

Note*: Prevention of hand foot syndrome using an antioxidant containing ointment in patients treated with pegylated liposomal doxorubicin – a randomized placebo controlled double-blind study. J Clin Oncol. 2015. http://meetinglibrary.asco.org/content/145854-156. Accessed April 19, 2016.

Stage_IV_in_Montreal

hello Giovanni - I saw your posts when I was on Xeloda and you were posting on "all about Xeloda". It seems that the worst side effects youR wife is having with Liposomal doxorubicin is with the feet. I am having a terrible time with nausea and fatigue. The anti-nausea drugs works but leave me feeling so tired. Does anyone else have experience with this Liposomal doxorubicinand the side effects?

Stage IV in Montreal

gciriani

Cycle four of Doxil every four weeks; actually the last infusion was done after five weeks from the previous one, because of travel. It's a mixed bag because she's tolerating it well, however, pain has increased all over the rest of her body (she had to start oxycodone), but the various bone and CT scans show the cancer is in status quo (the MO is surprised by the conflicting info).