Melatonin

lisametoo

Melatonin

lisametoo

Another great study:  http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16647824&itool=pubmed_docsum

Melatonin is non toxic as demonstrated by animal & human studies & use. In one experiment a man took 6,600 mg daily for 35 days with no adverse effects. The usual dose is 0.25-3 mg. Though non-toxic, melatonin can have some side effects if you take a dose which is too high for you. If you decrease the dose, the side effects should disappear. The most common side effects would be grogginess, hangover, or headache in the a.m. or intense dreaming. Doses over 10 mg daily can decrease ovarian activity & suppress sex hormone function. However these higher doses also decrease the activity of the estrogen binding receptors in the breast & may be protective against breast cancer & a useful adjunct in treating breast cancer.

paige-allyson

This is an interesting topic, thanks for the link. I wonder about using melatonin if one is also on tamoxifen or an AI. I'm going to add this topic to my "to research" list but am interested in anything others have learned. Allyson

Bliz

My Med onc discouraged the use of melatonin.  Said it was a hormone that could encourage recurrence.  I am ER positive.

NativeMainer

The research I've found on melatonin all seems to be along these lines, but I would always go by the doctor's advice:

Hormone Melatonin Slows Breast Cancer

Bright Light at Night Linked to Increased Cancer Risk By Daniel J. DeNoon
WebMD Medical News

July 14, 2003 (Washington, D.C.) -- The nighttime hormone melatonin puts breast cancer cells to sleep. It also slows breast cancer growth by 70%.

 

David E. Blask, MD, PhD, of Bassett Research Institute in Cooperstown, N.Y., reported the findings at this week's annual meeting of the American Association for Cancer Research.

 

Breast cancers get revved up by a kind of dietary fat called linoleic acid. Melatonin interacts with linoleic acid, so he gave melatonin to mice implanted with human breast cancers.

 

"This breast cancer rev-up mechanism gets revved down by melatonin," Blask said at a news conference. "Nighttime melatonin is a relevant anticancer signal to human breast cancers. Ninety percent of human breast cancers have specific receptors for this signal."

 

The hormone seeps from a pea-sized gland in the brain when the lights go out at night. It's the reason you get sleepy when it's dark. Blask and colleagues found that melatonin puts cancer cells to sleep, too.

 

Blask's team exposed lab mice with human breast cancers to constant light. Tumor growth skyrocketed.

 

"With constant light, tumors grow seven times faster and soak up incredible amounts of linoleic acid," he says. "During the day, the cancer cells are awake and linoleic acid stimulates their growth. But at night cancer cells go to sleep. When we turn on lights at night for a long time, we suppress melatonin and revert back to the daytime condition."

 

The finding may explain why nurses who often work the night shift have high rates of breast and colon cancer.

 

Blask says clinical trials are under way to see whether melatonin supplements can help treat cancer. It may also help in other ways.

 

"When you take melatonin prior to normal onset of sleep, it will [jump-start the sleep cycle]," he notes. "Many cancer patients suffer from sleep problems. Melatonin may also improve the quality of life in cancer patients by helping them sleep."

 

Arizona Cancer Center researcher David Alberts, MD, notes that there is a lot of interest in melatonin as a sleep inducer. However, he worries about the safety of over-the-counter melatonin supplements.

 

"The issue is safe dosing of melatonin," he said at the AACR news conference.

 

Provided that melatonin supplements actually contain the hormone, Blask isn't worried about overdose.

 

"In human studies, melatonin has basically no toxicity," he tells WebMD. "Now it takes very little melatonin to stimulate nighttime sleepiness -- on the order of three-tenths of a milligram. But you can't overdose with melatonin. People have taken gram quantities. Its nastiest side effect is sleepiness."

 

View Article Sources SOURCES: American Association for Cancer Research 94th Annual Meeting, Washington, D.C., July 11-14, 2003. David E. Blask, MD, PhD, Bassett Research Institute, Cooperstown, N.Y. David Alberts, MD, Arizona Cancer Center.

http://www.webmd.com/breast-cancer/news/20030714/hormone-melatonin-slows-breast-cancer

Calico

My onc told me last year to try it. He takes it too, but only 3 mg and he told me that there are trials with high doses going on.

I take 6 mg and would like to go up another 3...... I did however read a controvers story that it could be bad.

Edge has positive reports on his site, I trust him.

God Bless

rubytuesday

According to research on LEF's website, Tamoxifen & melatonin work synergistically.  Best wishes

BTW, awhile back, I posted research that reported that melatonin is also good for your bones .

lisametoo

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17541739&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=17130668&itool=pubmed_docsum

http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16647824&itool=pubmed_docsum

NativeMainer

Thanks for the links, Lisa!  Very promising research, I hope someone takes it to the in vivo level soon.

lisametoo

Here is more on melatonin:  http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WN2-46MCB42-20&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a344a0bae670f662cb2bf7a45ddc217e