D3

mkl48

New info today on D3.  Instute of Health study did not find link between D intake and cancer. Not sure if D3 was measured. Colon cancer was seemingly influenced, but they did not assess independently for activity, diet or obesity. Beth

Rosemary44

Vitamin D, the anti-aging vitamin?

http://www.medicalnewstoday.com/articles/88298.php

BlindedByScience

Hmmm, maybe if I opened the oil-filled softgels and smeared it on the bags & wrinkles around my eyes....it's cheaper than Oil of Olay.

Rosemary44

Well if you open up a fish oil, and add D to it, then schmeared, you'd be putting Oil of Olay out of business.  I think it best to use the coramega for that.  Otherwise, I wouldn't want to think about it.

BlindedByScience

Rosemary, I laughed when I saw your post, but I started thinking about it a little more--topical application of flaxseed oil has been used to treat skin inflammations like psoriasis and help keep the itching down. If fish oil were used, the omega-3 fatty acids would be even more easily used by the tissues.

Adding Vitamin D & E (for it's antioxidant/preservative properties) couldn't hurt.  And I have some 'molecularly distilled' Norwegian fish oil. Perhaps it would have less odor. 

You're right. I think we could put Oil of Olay out of business! 

Anonymous

Coramega!!!!  No way!  It's too yummy to use as a cosmetic.

Rosemary44

Kris,

Just to add a little more to the ingredients, Sophia Loren puts olive oil in her bath water.  She looks marvellous.

So we start with olive oil blended together with flax oil w/lignans.  Too bad turmeric stains, cause there's no better in healing skin lesions with turmeric and aloe vera combined.  Inflamed gums, those two are gems for that problem.

Add some fish oil, non repulsive kind..

(Sorry Shirley, have you ever opened up a fish oil tablet?)

Vitamin D, what's the E for? 

Doesn't Norwegian fish oil have vitamin A?  We don't want that in our perfect skin care and anti-inflammatory lotion.

I know a lady who can actually mix this up and with a lanolin base.  When we sell it on-line we'll need a sexy name.

BlindedByScience

How about Crème du Soleil? or Crème du Soleil-Mer?

The vitamin E is to act as an antioxidant, and will help preserve all those fragil omega-3 fatty acids. In fact, our Anti-Aging Beauty Treatment may need refrigeration. 

Leave out the lanolin and add in the Coramega or other flavors and voilà--we can launch our erotic massage oil line with Wild Berry Nights and Warm Citrus Encounters. Maybe even Lime Light Romance.

saluki

Kmb---

Anti-cancer effects don't really kick in below blood concentrations of around 30 nanograms per milliliter, and that the vast majority of individuals in western nations really don't come anywhere that level without supplementation and/or frequent sun exposure.----Scientific American (Nov 2007, pp. 62-72)

 That study used a single 25(OH)D measurement between 1988–1994   as their sole predictor of all-cause cancer mortality over the next 6-12 years. That level may have varied significantly during the period studied.

A more valid study would be if it actually included a group of individuals receiving enough vitamin D to see an effect.
--------------------------------------------------------------------------------------------------

 Journal of the National Cancer Institute Advance Access originally published online on October 30, 2007
JNCI Journal of the National Cancer Institute 2007 99(21):1594-1602; doi:10.1093/jnci/djm204
This Article


Published by Oxford University Press 2007.
ARTICLES
Prospective Study of Serum Vitamin D and Cancer Mortality in the United States

D. Michal Freedman, Anne C. Looker, Shih-Chen Chang, Barry I. Graubard

Affiliations of authors: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (DMF, SCC, BIG); National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD (ACL)

Correspondence to: D. Michal Freedman, PhD, MPH, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Executive Plaza South Rm 7036, 6120 Executive Blvd, Bethesda, MD 20892-7238 (e-mail: mf101e@nih.gov).

Background: Vitamin D has been hypothesized to reduce cancer mortality through its effects on incidence and/or survival. Epidemiologic studies of the association of 25-hydroxyvitamin D [25(OH)D] and the risk of cancer, however, have been largely limited to incident cancers at a few sites.

Methods: A total of 16818 participants in the Third National Health and Nutrition Examination Survey who were 17 years or older at enrollment were followed from 1988–1994 through 2000. Levels of serum 25(OH)D were measured at baseline by radioimmunoassay. Cox proportional hazards regression models were used to examine the relationship between serum 25(OH)D levels and total cancer mortality (in the entire population or according to race/ethnicity, sex, age, and retinol status) and mortality from specific cancers. Because serum was collected in the south in cooler months and the north in warmer months, we examined associations by collection season. All statistical tests were two-sided.

Results: We identified 536 cancer deaths in 146578 person-years. Total cancer mortality was unrelated to baseline vitamin D status in the entire population, men, women, non-Hispanic whites, non-Hispanic blacks, Mexican Americans, and in persons younger than 70 or 70 years or older. We found no interaction between vitamin D and season or vitamin D and serum retinol. Colorectal cancer mortality was inversely related to serum 25(OH)D level, with levels 80 nmol/L or higher associated with a 72% risk reduction (95% confidence interval = 32% to 89%) compared with lower than 50 nmol/L, Ptrend = .02.

Conclusions: Our results do not support an association between 25(OH)D and total cancer mortality, although there was an inverse relationship between 25(OH)D levels and colorectal cancer mortality.


CONTEXT AND CAVEATS

Prior knowledge

Based on epidemiologic studies, vitamin D has been hypothesized to reduce cancer mortality.

Study design

Cox proportional hazard regression models were used to examine the relationship between serum vitamin D level measured in participants in a nationwide survey of health and nutrition and cancer mortality.

Contribution

This study found that total cancer mortality was not related to vitamin D status but that higher levels of vitamin D may be associated with a reduced risk of colorectal cancer mortality.

Implications

inverse associations between a surrogate for vitamin D status and cancer mortality reported previously are not supported by the results of this study.

Limitations

This study lacked power to clarify associations between vitamin D status and particular cancers for which there were insufficient deaths, and it relied on a single measurement to reflect serum vitamin D status.

 
We thank Donna J. LaVoie (MT)ASCP and Della B.Twite (MT)ASCP for performing the NHANES III 25(OH)D assays, Lisa Kahle of Information Management Services, Inc, for biomedical computer assistance, and Drs Martha Linet and Elaine Ron for insightful comments. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. The National Center for Health Statistics of the Centers for Disease Control and Prevention was responsible for the data collection and design of the NHANES III.

Manuscript received March 7, 2007; revised July 20, 2007; accepted September 26, 2007.


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    Cindy D. Davis and Johanna T. Dwyer
    J Natl Cancer Inst 2007 99: 1563-1565. [Extract] [Full Text]

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The "Sunshine Vitamin": Benefits Beyond Bone?
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Rosemary44

Holy hot flash Kris, your warming up the room.   Ahhh, that's right vitamin E is a preservative.  This is beginning to sound very edible too.  Forget the internet sales, I'll just buy all the bottles.  Excuse me while I go sit in my refrigerator for a bit and cool down.