It's back...What New in tx?

Options
FloridaLady
FloridaLady Member Posts: 2,155
edited June 2014 in IBC (Inflammatory Breast Cancer)
It's back...What New in tx?
· Share on FacebookShare on Twitter

Comments

  • FloridaLady
    FloridaLady Member Posts: 2,155
    edited June 2008

    Hi ladies... you may have seen me post in other areas.  I'm triple neg and have had 7 recurrences to chest wall.  Two years ago I was treated for skin mets and have not had any issues in this area until now.  Last couple of weeks I have been watching a area on my right shoulder and chest wall. Then last week it took off like wild fire and covered my whole shoulder/chestwall and upper arm. 

    My question is... What is new for chemo in the way of IBC tx?  I have already taken ACT (T-taxotere), Gemzar-Carbo-Avastin and a Phase I trial at MD Anderson that gave me sever neuropathy.  I just got the use of my hands and feet back after a year from last chemo. My doctor wants me to do Ixempra (outside of a trial) but I heard nothing but bad things about neuropathy and this drug.  I don't think I can go back there...I could not even hold a book and turn the page my hands were so bad.  I live alone and could not drive for six months.  I have done extremely well on all my chemo's worked full time through all (16 mths) except the MDA trial where they overdosed us on propose knowing it was a poor breast cancer drug.  Do you know of anything beside Ixempra?

    FlaLady

    · Share on FacebookShare on Twitter
  • AlaskaDeb
    AlaskaDeb Member Posts: 2,601
    edited June 2008

    Hey there-

    I know squat about IBC other than I have one friend who had it.  I can tell you a bit about my conversation with my Onc about picking mets chemos....

    We ended up going with a drug I had used before, Taxol, and added Avastin and Zometa.  She said that there was no "lifetime max" on Taxol, it had worked in the past and I did well on it.  We added the Avastin becasue it is so promising on triple negs.  Zometa was to help keep my bones strong to fight the bone mets....

    One qusetion you might want to ask you doc is if there is one of your drugs that worked well before that you can go back to.  If you quit it after it was successful, you may be able to reuse it.  If the Avastin did not cause you really bad side effects, maybe they can add that back in too.

    I wish I had more info on IBC....did they do scans to see if it is anywhere besides the skin? 

    Crap, I hate cancer!  Wish I had some wise words for you.....

    Hugs

    Deb C

    · Share on FacebookShare on Twitter
  • shrink
    shrink Member Posts: 936
    edited June 2008

    I'm an IBCer diagnosed about a year ago.  From what I understand IBC is treated in the same way as any aggressive breast cancer - chemo, surgery and radiation for those in Stage III at least.  Chemo is usually given first in order to shrink the tumor and prevent its spread to other areas.  I don't think there's anything available yet specifically for IBC. I wish there were.

    · Share on FacebookShare on Twitter
  • TenderIsOurMight
    TenderIsOurMight Member Posts: 4,493
    edited June 2008



    As of June, 2008, Bristol-Myers Squibb will finish up a Phase II trial on Dasatinib, a small molecule therapy agent, in triple negative disease. If response was noted, a Phase III trial will presumably follow. Duke, in conjunction with Bristol-Myers Squibb is also active in a phase II trial of Dasatinib (with a site in Florida). Below are some information links, should you wish to read more. I'm posting this here because while it's IBC, the underlying pathology is triple negative.



    1.A Study of Dasatinib (BMS-354825) in Patients With Advanced 'Triple-Negative' Breast Cancer

    http://clinicaltrials.gov/ct2/show/NCT00371254?term=triple+negative,+breast+cancer&rank=3





    2..Dasatinib may also inhibit c-Kit in triple negative breast cancer cell lines

    Journal Breast Cancer Research and Treatment

    Publisher Springer Netherlands

    ISSN 0167-6806 (Print) 1573-7217 (Online)

    Issue Volume 107, Number 2 / January, 2008

    http://www.springerlink.com/content/508452872342r245/



    3..Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/“triple-negative” breast cancer cell lines growing in vitro

    Journal Breast Cancer Research and Treatment

    Publisher Springer Netherlands

    ISSN 0167-6806 (Print) 1573-7217 (Online)

    Issue Volume 105, Number 3 / November, 2007

    http://www.springerlink.com/content/y7wp30p7534020vq/

    Quote from paper " Importantly, these data provide scientific rationale for the clinical development of dasatinib in the treatment of women with “triple-negative” breast cancer, a subtype that is categorized as being aggressive and lacking effective treatments (i.e., hormonal manipulation or trastuzumab)."



    4.Phase II Dasatinib Study in Advanced Breast Cancer (Recruiting)

    http://clinicaltrials.gov/ct2/show/NCT00546104?term=dasatinib,+breast+cancer&rank=4



    All my best,

    Tender

    · Share on FacebookShare on Twitter

Categories