Thyroid Hormone Appears to Increase Breast Cancer
Comments
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http://healthnews.benabraham.com/html/thyroid_hormone_therapy_appear.html
Dr. James Howenstine, MD.
NewsWithViews.com
7/29/06Medical journals and textbooks typically portray iodine as an unimportant substance which should be taken in small amounts[1] because of it's dangers. Actually approximately one third of humanity has iodine deficiency.
When humans lack iodine the thyroid gland enlarges (goiter), nodules appear in the thyroid gland and over a period of time cancer may appear in a thyroid nodule. Conventional medicine treats thyroid gland enlargement with thyroid hormone without considering the possibility that the hypothyroidism and goiter may be due to lack of iodine. This failure to diagnose and treat iodine deficiency can lead to an increased risk of breast cancer and the longer the diagnosis is missed the greater the chance that breast cancer will occur. Women taking thyroid hormone appear to be twice (12.1%) as likely to develop breast cancer as women not using thyroid hormone (6..2%). Women who had taken thyroid hormone for 15 years had a 19.5% incidence of breast cancer whereas women who have only taken thyroid hormone for 5 years had only a 10% incidence of breast cancer. Why is this?
The essential trace element iodine may be the most important least publicized mineral in existence. Iodine is the only element needed in hormones and in the production of hormones. The iodine containing hormones are involved in the creation of embryos, development of brain function, growth, metabolism and maintenance of body temperature. This means that proper amounts of thyroid hormone, estrogen, progesterone, testosterone, insulin, growth hormone etc. can not be made when iodine is lacking from the body. One third of all individuals on Earth are functioning with subnormal levels of iodine. Low intake of iodine is the leading cause for intellectual deficiency in the world.
There is strong evidence that iodine lack predisposes to breast cancer. One out of seven women in the U.S. has deficiency of iodine proven by urine iodine screening tests (urine I less than 50 ug/L). This is the same incidence for breast cancer seen in U.S. women. Without bothering to check urine for iodine, physicians visited by a woman with a goiter or symptoms of hypothyroidism are routinely prescribing thyroid hormone therapy.
Hintze et al[2] compared the results of 400ug/L of Iodine with 150ug of T4 (synthyroid) for 8 months and then four months after stopping therapy. The results clearly favored iodine therapy. Both treatments led to similar suppression in the size of the goiter. However, four months later the size of the thyroid had returned to pre-treatment levels in the group treated with T4 hormone. The group who had received iodine therapy continued to have normal sized thyroid glands four months after therapy was stopped. Several investigators have concluded that iodine lack is a probable cause for breast cancer in women.[3] [4] [5] [6] [7]
Demographic studies in Japan and Iceland revealed that both countries have a high intake of iodine and low incidences of goiter and breast cancer. In Mexico and Thailand where iodine intake is low there is a high incidence of goiter and breast cancer.[8] Thyroid gland size measured by ultrasound is significantly larger[9] in Irish women with breast cancer than control women.
Administration of thyroid hormone to iodine deficient women appears to increase the risk of developing breast cancer. In a group of women undergoing screening mammograms the incidence of breast cancer[10] was twice as high in the women taking thyroid hormone. for hypothyroidism (probably caused by iodine lack) than in women not taking thyroid supplements. The mean incidence was 6.2% in controls and 12.1% in women on thyroid hormones. The incidence of breast cancer was twice as high in women taking thyroid hormone for more than 15 years (19.5%) compared to those on thyroid hormones for only 5 years (10%).
In the state of Michigan, during a period of iodine supplementation in bread (1924-1951) the prevalence of goiter diminished from 38.6% to 1.4%. Of interest the incidence of breast cancer remained unchanged during this time frame. This information was used to suggest that iodine supplementation had no effect on the incidence of breast cancer. However, Ghent and Eskin were able to show in women and female rats that the amount of iodine needed to protect against fibrocystic disease of the breast and breast cancer was at least 20 to 40 times greater[11] than the iodine needed to control goiter.
In the 1960s mandated iodine containing dough was equivalent to the RDA of 150 ug per slice of bread. At that time the incidence of breast cancer was only 1 in 20.[12] In the past 20 years the use of iodine supplementation in bread was eliminated and a goiter producing substance toxic to the thyroid gland (bromine) was introduced as replacement for iodine. The risk for breast cancer is now 1 in 8 and this risk is increasing by one percent[13] each year. The decision to replace iodine in an iodine deficient population with a goitrogen was illogical lacking in common sense. The damaging effects of bromine on thyroid tissue also appears to contribute to the development of auto-immune diseases in the thyroid gland (Hashimoto's thyroiditis).
The mammary glands have a trapping system for iodine similar to that of the thyroid gland. The breasts effectively compete with the thyroid gland for ingested iodine. This distribution of iodine to both breast and thyroid gland in pubertal girls explains why goiter is 6 times more common in girls than pubertal boys. The disappearance of iodine into breast tissue in women leads to decreased ability to supply the thyroid gland with an adequate amount of iodine. The development of a goiter in young girls indicates deficient distribution of iodine to both breast and thyroid tissue. Treating such a patient with thyroid hormone is not sensible and appears to increase the risk of breast cancer.
Study of radioiodine uptake in normals and women with fibrocystic breast disease FDB reveals that the FDB breasts were able to take in 12.5% of the iodine dosage compared to only 6.9% in normal breasts. This proves the existence of considerable iodine depletion in the breasts of women with FDB.
There is considerable evidence for an increased risk of thyroid cancer as well as breast cancer in persons with iodine deficiency. Untreated iodine deficiency leads to goiter, thyroid nodules and eventually some of these nodules become malignant. The decreasing intake of iodine has resulted in an increase in thyroid nodules and increase in thyroid cancer. In 2001 there were 19,500 new cases of thyroid cancer in the U.S. with 14,900 of these cases occurring in women.
Iodine has a role in promoting general well being as well as protecting against infections, degenerative diseases and cancer. Iodine promotes the normal killing of defective and abnormal cells (apoptosis). Thus, iodine helps the body's surveillance system to detect and remove abnormal cells. Additionally, the presence of iodine triggers differentiation away from the more dangerous undifferentiated type of cell toward normal cells. The presence of adequate levels of iodine in the body (Japanese diet with lots of sea vegetables and fish) reduces reactive oxygen species (ROS). in the body which decreases the oxidative burden in the body. This results in slowing of degeneration disease processes and decreasing the risk of cancer.
Nearly every physician in the United States will reach for a prescription pad to order thyroid hormone when he sees a patient with goiter or symptoms of hypothyroidism. This can be exactly the wrong thing to do if the patient has deficient stores of iodine. Insist on obtaining a 24 hour urine collection for iodine to eliminate iodine lack as the cause for your symptoms (values below 50 ug/liter are abnormal). Thyroid hormone therapy in the presence of iodine deficiency increases the risk of breast cancer and probably thyroid cancer as well. Endocrinologist, Dr. Guy Abraham, formerly of the U.C.L.A. Department of Endocrinology, is convinced that everyone needs to be on iodine therapy until their iodine stores have been fully restored. After this time frame periodic intake of iodine will help insure that the many body functions requiring iodine run smoothly.
A dosage of two tablets of Iodoral twice daily for three months followed by one Iodoral tablet daily for a year will restore iodine stores for most persons. At that point periodic taking of an Iodoral tablet daily one month out of 4 to 6 months etc. will be adequate to maintain iodine stores. Iodine stores can be easily monitored by taking 4 Iodoral tablets (50 mg iodine) and collecting a 24 hour urine sample for iodine content. If 80% of the ingested iodine is found in the urine collection the iodine stores are normal. Iodoral can be obtained from Optimox Corp. Torrance, Cal. To purchase a referral from a health care practitioner is needed.
Footnotes:
1, Abraham, Guy F. et al Orthoiodosupplementaion: Iodine Sufficiency Of The Whole Body pg 1
2, Hintze, G. et al treatment of Endemic goiter due to iodine deficiency with iodine, levothyroxine or both:results of a multicentre trial. European Journal of Clinical Investigation, 19:527-534, 1989
3, Eskin B et al Mammary Gland Dysplasia in Iodine Deficiency JAMA , 200:115-119. 1967
4, Eskin B Iodine and Mammary Gland Cancer Adv. Exp. Med. Biol., 91:293-304, 1977
5, Ghent, W. et al Iodine Replacement in Fibrocystic disease of the Breast Can. J. Surg. , 36:453-460, 1993
6, Eskin B. et al Different Tissue Responses for Iodine and Iodidein Rat Thyroid and mammary Glands Biol. Trace Element Research 49:9-19, 1995
7, Derry , D Breast Cancer and Iodine Trafford Publishing, Victoria B.C. , 92, 2001
8, Finley JW., Bogardus, G.M., Breast Cancer and Thyroid Disease Quart. Review Surg. Obstet. Gyn. 17:139-147, 1960
9, Smtyhe, P. , Thyroid Disease and Breast Cancer J. Endo. Int. , 16:396-401, 1993
10, Ghandrakant, C. et al Breast Cancer Relationship to Thyroid Supplements for hypothyroidism JAMA, 238:1124, 1976
11, Backwinkel, K., Jackson, A.S. Some Fearures of breast Cancer and Thyroid Deficiency Cancer17:1174-1176 , 1964
12, Epstein, S.S., Sherman, D. Breast Cancer Prevention Program Macmillan , NY. 1998 pg 5
13, Ibid
Original story with live links to footnotes can be found here:
http://www.newswithviews.com/Howenstine/james47.htm
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Hi... I didn't read this entire article, but it really angers me when they try to scare us from taking something that we actually NEED! If we are dx'd with hypothyroidism, then our bodies NEED thyroid hormone! This is how it works:
the pituitary gland releases TSH, or thyroid stimulating hormone, which in turn tells the thyroid gland to 'make more thyroid hormone', or T4. If it is overworked, stressed, or whatever, it CAN NOT keep up with the production of thyroid hormone. This is why we need to take this very important supplement....
Iodine... well, except if you live in a third world country, you probably DON'T have an iodine deficiency!! Here in the U.S., we have IODIZED salt, which has IODINE in it... so, no worries there.
Grrr....
Harley
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Harley, iodine connects with the same receptors as chlorine and bromine. Every time we take a shower, we are being doused with chemicals that compete with our iodine uptake, unless you have filters to remove the chlorine. The article also mentions how iodine used to be in our bread products but was removed 20 years ago in favor of bromine. And with so many people battling high blood pressure, salt is not consumed at the same rate it once was. And some of the sea salt products don't have any iodine at all.
Just as a simple test look in your medicine cabinet and see if you have some iodine solution for first aid purposes, or get some at the store. Swab a 2" circle onto your arm or thigh and see how long the stain is visible. My body soaks it up like a dry sponge. If your levels are sufficient, the stain should still be visible 8 hours later. It's not a perfect test, but it's cheap, it's easy, and it doesn't hurt.
You might be surprised to learn that you too could be deficient in iodine. We've had several discussions in here about iodine. My head was swimming just 3 months ago because of it. Mainly I was confused at the huge disparity of information. The USDA people say the daily allowance is 150 micrograms and it starts to be toxic at 1,100 micrograms. At that time I was contemplating some iodine supplements which were 3 milligrams each, which is nearly 3 times what the USDA says is toxic!
How can there be so much disparity on this topic? And, more important, who am I supposed to believe? The more and more that I read, the less and less I trust mainstream providers. The people who seem to have the best interests of people and their GOOD health are in the alternative groups. That is what I'm finding anyway. The alternative folks say up to 50 milligrams in a day is ok to take in certain circumstances, such as doing a test or correcting a deficiency. That is a vast amount of iodine compared to what the USDA says is toxic.
Harley, if you do the home test for iodine deficiency and see the iodine disappear into your skin rapidly, there's a more accurate test that can be done via mail order. And there's a mountain range of information out there on iodine. It can be overwhelming, but for me, I would far prefer getting rid of my iodine deficiency in hopes of getting my thyroid in balance than take a scrip.
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thanks for sharing this article..it gives us something to think about.
found this after reading your post:
http://www.breastcancerchoices.org/IodineInvestigation.html
so Iodine/thyroid/bc is a concern.
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Althea,
I read your post after my submit...I'm going to try the iodine to my forearm and see...thanks for the tip!
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Do a search on this doctors name that wrote the article. He's pretty far fetched by my reading in a lot of ideas.
The one belows says NO one should use vaccines!
http://worldvisionportal.org/wvpforum/viewtopic.php?t=621
One has to really read between the lines anymore on the internet, as you can find just about anything you want to support your ideas.
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althea,
Yes, if it were ONLY that simple!! It is really just that so many respected medical professionals, and respected medical articles state clearly that iodine deficiency is really not a problem, in developed countries.
Sorry, but I just don't think it is that simple...Respectfully,
Harley
P.S. Thyroid deficiency, aka hypothyroidism runs in my family, as does Hashimoto's, which is auto immune. This is the reason I need to take thyroid hormone, because my body doesn't recognize my own thyroid as belonging...it's constantly trying to 'kill' it off... (that is just a simplistic way of describing it)
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Harley,
I am a medical professional and agree with you about family history "hashimoto" "Hypothyroid" not always caused by something as an iodine deficiency....also I agree that iodine deficiencies can cause thyroid problems...even though thyroid problems aren't always caused by Iodine def.
my mom has hypothyroidism and is on medicine....often when women go through menopause, low thyroid affects them as well...
God bless and wishing you excellent health
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This is an interesting discussion. I followed the iodine thread posted earlier, too, and I think there may be something here, but it's hard to determine exactly what is the action plan if you are considering the premise that iodine deficiency is linked to bc. In the article above, I don't think the author is saying that using thyroid hormone increases the risk of breast cancer. I think he's saying that we are failing to treat the underlying cause of some cases of hypothyroidism and that underlying cause (iodine deficiency) can predispose us to bc.
His complaint is that doctors fail to recognize iodine deficiency as a potential cause of hypothyroidism. They treat with hormone when, according to the author, iodine supplementation is needed. So there's a coincidental connection between taking thyroid hormone and increased rates of bc: taking the hormone is not a cause of bc.
Many things have changed in the last 20 years that could be activators of latent bc in our bodies. One small European study found a significant number of women of 80 or older who had died from other causes but had DCIS--it never became invasive, and was detected only on autopsy. So, if we look for what's different in our lifetimes from theirs, lots of things turn up.
In general, the US population:
gets less unfiltered sun exposure (vitamin D deficiency)
gets less exercise in our daily routines
ingests transfats & high fructose corn syrup (last 25 years or so)
So, it could be possible that the trace amounts of iodine people used to get have diminished or are outcompeted by bromine, chlorine & fluorine. We are exposed to lots of chlorine (and/or bromine) in treated water like that used in hot tubs, swimming pools and some public water supplies. The iodized salt you can bring home from the grocery is the only iodized salt you're likely to get--for example, salty snack foods don't usually use iodized salt.
I haven't seen good evidence that painting iodine on your skin and timing it's absorbtion is a good indicator of the body's iodine status. Perhaps the urine test would be the better test for anyone considering an evaluation.
But, I'd venture a suggestion: there are sources of iodine that you can take as a supplement (like Iodoral) and sources of iodine you can take as a food. In the case of iodine, I'd rank whole food over supplement and recommend incorporating some of the red & brown seaweeds in your diet. If that sounds yucky, they come in capsules, too.
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The World Health Organization estimates Americans are consuming 50% less iodine they did in 1970. They calculated this from urinary iodine excretion. 30 years ago, iodine used to be added to flour and bread. Then it was removed and replaced with bromate-- which makes your body excrete iodine.
Add to that the mass introduction of bromide fire retardants (computers, phones, TVs, mattresses, furniture, pillows) and it is easy to see how our iodine got pushed out of our bodies.
It isn't that taking thyroid meds is bad. It appears that the meds may BLOCK some iodine and cause a deficiency. As long as a person takes a healthy iodine supplement to compensate for the iodine loss, thyroids meds will probably be okay. A third of the women who take iodine find they don't need thyroid meds after a few months.
If you are skeptical about this info, look it up. Nobody's trying to scare anybody. I did a lot of head-scratching when I heard it too. It took months for me to verify it. This information is too important to sweep under the rug.
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So, can our primary docs do an Iodine test?
I was dxd hypo many years ago. We didn't have chlorine or fluoride in our water..had well water. Now, for the past couple of years we're on a county system. I'm on Synthroid. My dd is also. So, this scares me!
Shirley
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This may seem a silly question, but is Synthroid considered a thyroid hormone? A girlfriend of mine is on a high dosage and has fibrocystic breasts - I am a bit worried.
Thanks - Raye
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Shirley,
Primary docs can order an iodine loading test (24 hour urine test).
But not all of them know how to prescribe from the results.
There is a consensus forming that if you have both breast cancer and thyroid disease, you need iodine. Ovarian cysts are also a result of iodine deficiency. Nobody knows exactly what the relationship is other than the three organs need a lot of iodine. It looks like, when the estrogen receptors don't get enough iodine, they get greedy and get hinky, causing swelling, cysts and nodules-- just like the thyroid.
There is a study by Smyth in Ireland. He measured the thyroids of breast cancer patients and found they were larger than nornal women. The thyroid swells in attempt to take up more iodine from the blood.
Anom
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Hi Rae,
Sythnthroid is considered the T4 thyroid hormone. Sometimes it makes fibrocystic disease worse. They think it does this by blocking some of the the absorption of iodine to the breast. If she needs to take Synthroid, maybe if she added iodine, the breast pain/cysts would improve.
I still take a small amount of T3 thyroid hormone (Cytomel) but compensate with iodine. Sometimes, in the late summer thru fall, I don't seem to need the thyroid. I can tell when I need it because my skin gets dry and I get cold easily.
Anom
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Ladies, I also am a believer in the iodine theory. In 1970, in upstate NY, my Dr. treated my thyroid with Lugol's iodine. My blood test showed hypothyroid, but I was 94 pounds and 5'4". He said there was no way I could be hypo thyroid and that skinny, so he did further tests including a nuclear thryoid scan and determined that my thyroid gland was not absorbing enough iodine from my body. You see, I had stopped even taking iodized salt due to acne. He treated me with the iodine until my thyroid became normal and then kept testing it for several months. Years later, I was again diagnosed with hypothyroid and this time, in another state, they put me on synthroid. I asked about the Lugol's iodine and the guy looked at me like I had horns coming out of my head! So, I have been on synthroid for about 10 years, and have had fibrocystic breasts most of those years along with hair loss and still didn't feel great.
It happens that I personally have known my oncologist for 6 years before being diagnosed with b/c. One of the first things she said to me was that she thinks my thyroid is involved!
Iodine can't hurt you in modest forms. I don't think any of these guys are suggesting taking mega doses. I have found several sites that have shown studies where Lugol's iodine has totally cured fibrocystic breast disease, which is a precursor to b/c.
I am going through chemo right now, but wish I had the money to go totally holistic. It just isn't right that our insurances will only pay for "western medicine" when there are many proven healings from other sources.
I have also seen other messages on this site where people have said their oncologists are using iodine as part of their treatment.
We MUST not keep our heads in the sand. At what point of suffering do you say, enough! And use your own intuitions and sources?
God Bless us all. I know I don't like being here anymore than anyone else, but am so grateful to have this source.
God's Love and Healing to all
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