UTI's and AI's
How many on aromatase inhibitors have had UTI's? I don't know for sure if I have one but I got a call today from my gyn office to give them a call. I went in last week for a pap test and they also took a urine sample. My gyn does not usually contact me unless there is a problem. If my pap test is fine I don't normally here anything. I am hoping it is just an infection and nothing more serious but after a cancer diagnosis I don't rule out anything anymore. I was reading that loss of estrogen can increase the risk for UTI's. Just another problem to add to the long list of side effects from aromatase inhibitors and an estrogen deprived body.
Comments
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I have been on Femara since 9/1/07 and have had 2 uti's since then....never really had any before that. Was pretty darn sick the first one...high fever and chills. I haven't heard that was a side effect though...food for thought. I might just have to research that.
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Hi LizM.
Just read your post and hope to reassure you that it is mostlikely some benign finding on your urinanalysis or possibly they didn't get enough cells on your pap smear and so called you.
On the AI's with our low estrogen state, even small amounts of blood cells may result from microfissures of the genital tissues caused by wiping in collection.
With a negative cervical workup as you had last year, it would be pretty unlikely for anything to pop up there too.
Lastly, I can't think of anything in a urinalysis which would be elevated in a breast cancer patient.
Try not to lose sleep over it. Highly unlikely this is anything related to the breast.
Tender -
Liz, you read the truth.(I bet you didnt read it in a LEF mag.)
Personally, I had my UTIs before bc, during natural menopause.Which does the same thing to the body as starting an AI.Depletes estrogen.
I even, on the fourth of July one year, seemed to be urinating blood.(festive!)The doc covering for my gyno said this is actually common in early menopause as the body gets used to the new estrogen level.It was a tiny fissure in my bladder wall which bled into my urine.
More of that UTI antiboitic.This one turned my urine orange.
I had cystitis, and cystitis which came from yeast infections which were caused by having sex with my new menopausal dry and brittle set-up.
I stopped them, finally, and still before bc by never using deoderant soap in the shower, never using any bath gel which had chemicals in it, and (best of all) getting rid of my husband.
I realize this solution isnt suitable for most womn.
The short answer..yes menopause ad AIs cause UTIs.
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Hi Liz,
<>
<>Did you have an abnormal pap? I am on Armidex (1 1/2 years) and on Zoldex Injectins.
<>I did and freaked but the outcome was okay. I ended up having to have the awful test done cant remember the name of it c something and they biopsed two areas just in case. The results were atropic changes due to menopause.
<>Hope you have good results.
<>Michele
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I think the connection between AI's and UTI's is largely due to the atrophying effect of nil estrogen. The same problems do occur commonly for women who are post-menopausal anyway; for those of us who experienced an overnight menopause due to chemo and then the lack of estrogen from an AI will obviously be more likely to experience this and more frequently.
Sam
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Liz
Just had my first UTI in over 20 years. I am almost 20 months on Aromasin, after an equal amount of time on tamoxifen. I didn't see my gyn, I saw my local internist who was thankfully in the office on New Year's Eve! I hope this is not a trend. I suspect part of the problem is extreme vaginal dryness due to lack of estrogen. I need to get on top of that, either with Vit E or Replens, as per my gyn. The doc said that in addition to dryness, there is often incomplete emptying of the bladder, also a lack of estrogen issue, that can contribute to UTI's.
I hope you have nothing more than a UTI, which although annoying, is highly treatable. Let us know.
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I have not yet had a UTI, but have noticed very frequent trips to the bathroom to pee, more than usual, and am wondering if it is somehow connected to Femara? Anyone else? And, while I am on the topic of possible SE's - how about blurry vision, not all the time, but for an hour or two most every day???
Debra
mets to bone 8/07
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Dear Liz,
I have been on both Femara and Aramisen for 6 months and then changed to Tamoxofen because of serious leg pain. After just 10 weeks, I have had a chronic UTI for 6 of those. Untreatable by antibiotics of any kind and I am now feeling desperate.
My onc. says it is the drying effects of Tamoxofen, but if I have to take this for 5 years, what kind of quality of life, can I expect.
All very tricky and depressing, especially when the GPs cannot help and my onc. is 2 hours away and too busy to give more than 5 mins.!!
I wish you luck. I am now trying alternative methods.
Rhonda
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Sashiko,
I researched alternative therapies for chronic urinary tract infections for my nursing-home bound Dad last year.
The one which stood out is D-Mannose. I believe it works by coating the bladder walls (it's a sugar) and hence does not allow the bacteria to attached to the bladder surface, so they flush out, enhanced perhaps by a good amount of cranberry juice or just plain water. What I liked about it was it's non-interference with blood sugar levels or multiple drugs being prescribed. There were some human research studies done too, showing efficacy, which is always reassuring.
Regrettably, with such low estrogen, the lower bladder and urethra (tube to outside) are affected too, as they are estrogen sensitive.
Good luck
Tender -
I second the use of D-mannose, tender. I always have a bottle or 2 around and I try to take it on a regular basis since 2005, along with cranberry and probiotics and plain yogurt almost daily. It's better to prevent them than to weaken our bodies with the constant use of antibiotics
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If the suggestions do not work I would try a Urologist.
Shirley
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just bringing this up to see what current thoughts folks have about UTIs, and AIs.
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I used to get UTIs rather frequently before breast cancer diagnosis, always after sex. I have been on anastrozole for 3+ years and have had none so far. Maybe it's because I am using more extra lubrication before sex now due to vaginal dryness caused by anastrozole.
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Hi everyone. Frequent UTIs are definitely a SE of anti hormones and lack off estrogen. So is interstitial cystitis which has the same symptoms but no infection. There are things you can do to prevent and lesson symptoms. Good luck to all...
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I'm doing all of the things for prevention. And then.all sorts of other things!
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I' ve been on letrozole for 7+ yrs and no UTI issues at all. I had gone through natural menopause 19 yrs pre going on Femara/letrozole and had had no UTI's during those yrs.
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