Herceptin during rads- any problems?

chemomom
chemomom Member Posts: 171
Herceptin during rads- any problems?

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  • chemomom
    chemomom Member Posts: 171
    edited January 2008

    Hi ladies.  I had a bil mast in Oct 07.  I have already done my time in chemo- 6 rounds of Taxotere, Carboplatin and Herceptin.  Last Thurs I had my first tx of Herceptin only and I am also up to tx 7 of rads.  Fri and most of the weekend, I had terrible pain in the area being radiated and it was VERY swollen and pink. 

    Since I have only had 7 rads, my rad onc insists the reaction could not have been just from the rads.  His best guess was that it was some negative interaction between having had my Herceptin infusion and rads too.  Has anyone heard of such a thing?

    I am so scared to go back for more rads now!  I have 30 more to go.   I got today off from tx, but I go back tomorrow morning.  Has anyone had a similar problem and/or heard of someone having an adverse reaction from doing rads and Herceptin at the same time?  Thanks.

  • KLynn
    KLynn Member Posts: 1,407
    edited January 2008

    Hi Chemomom,

        I didn't get my herceptin until after my radiation was finished, but that was 7 1/2 yrs ago. At that time herceptin was still in trial, so that may be why it is different . I was in the original trial, and had herceptin for 1 yr. back then. I am back on hercetpin again now, for about 2 yrs, but I haven't had any radiation this time around. I don't know anyone that has had both radiation and herceptin at the same time, sorry I'm not much help there.  If you're not handling both together and are having problems I think the doc would be able to hold the hercetpin until you are done with the rads. Are you getting the hercetpin weekly or every 3 weeks??? How many rads do you have left?? I also get 2d echos every 3 months to watch my heart, and so far no problems there, even after all these years. Holding the herceptin  would probably be your best bet, well good luck with everything. Talk to you soon, Hugs KLynn

  • lexi4
    lexi4 Member Posts: 1,074
    edited January 2008

    Hey chemomom,

    I had rads along w/ the herceptin. I don't think it caused any extra problems. I did have a bolus every other rad tx as I had an affected area on my skin. I have read that there can be some sensitivity to the rads when given during the herceptin txs. I thought that I had read that the rads and herceptin may actually work together to eliminate the ca cells in the affected area.

    I do hope that you get some relief soon since you have quite a few more to go. But you will be done soon! Herceptin alone is really quite easy for most. Hang in there!

    Hugs,

    Lexi

  • LittleFlower
    LittleFlower Member Posts: 405
    edited January 2008

    Hi Chemomom,

    i had herceptin as scheduled during rads.  I did have a shingles outbreak during rads, that was more like small vesicles, looks like a rash and can be very painful.  Thankfully it was caught early and treated successfully.  I was told that it could have happened because of the chemo i had done and then the added physical stress of rads just wore me out-- which i can agree with completely!

    Has your rads oncologist looked at this site?  are you using some lubricating ointment to prevent burns from rads?  I remember that for the first couple of weeks they boosted the rads with a bolous and that was something that may have caused skin redness and irritation and my rads doc always monitored for that. 

    just throwing out some suggestions.  All in all i got through rads ok- if you're concerned, talk to your med. oncologist too, have them talk about what the best step in your treatment might be.

    Don't be afraid- you'll get through this one step at a time, like all the other stuff you've already gotten through!

    Take care (((chemomom)))

    LittleFlower

  • Brenda_R
    Brenda_R Member Posts: 509
    edited January 2008

    I don't know about skin interactions, but I had to wait until after rads to start my Herceptin,

    because I had A/C, rads over the sternum, and the Herceptin. My Onc said it would be too hard on my heart to have the Herceptin while getting the rads.  

  • nagem
    nagem Member Posts: 353
    edited January 2008

    I had radiation and herceptin simultaneously with no particular difficulty. I found that doctors tended to discount side effects from their treatment, blaming it on other treatment. Nurses, on the other hand, tended to be more realistic (and less defensive?) and have practical suggestions. There is more than one unguent for keeping the area moisturized, and some work better than others for different people. So you might ask about that. Good also to network with other people in the radiation waiting room, I found. Good luck to you. Just a few weeks more, and this will be behind you.

  • anneshirley
    anneshirley Member Posts: 1,110
    edited January 2008

    I'd been under the impression that with a mast. one was not given radiation, unless nodes were involved?  I read a number of posts on this board where women said they were having a mast. to avoid radiation. Does anyone else out there know about this?

    But about the two together, herceptin and radiation, I had mine together and was told by my radiologist that the two together were more effective in killing off any remaining cancer cells.  However, she also told me, when I was complaining of my burns that having herceptin and radiation together tended to create more serious burns for some people.  I almost quit twice and the radiologist talked me into continuing.  I was very sore and looked awful--skin was very red with a wide rash over entire area.  However, when it was over I insisted on a prescription for Silver Sulfadiazine cream.  Nothing else had worked, not any of the creams they gave me (biafine, in particular) or any of the over-the-counter creams they suggested I use.   The sulfa medication worked almost instantly to give me both relief from pain and to get rid of the burns.  The skin peeled and healed almost immediately.  When I asked why they didn't give it during treatment, my radiologist talked around the question, something, as I remember, about too many antibiotics being dangereous.  Memory is bad on this but this drug lived up to its reputation as a miracle drug, and I now keep a tube in the house for burns.

    I can remember very clearly how awful I felt so you have my great sympathy. I did talk to other women at the center, but some had minor burns and one woman had open sores, so we were all different in our reactions.  Are you having a boost at the same time as the radiation--that can make a difference too.  But talk to your radiologist and your other doctors.  Don't suffer without getting relief.   

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