PROGNOSTIC sig.of grading in ilc

matic22 · November 2007

matic22 · November 2007

Abstract from Medline: return to Search Results

Acta Oncol, January 1, 2007; 46(6): 803-9.

Invasive lobular breast cancer. Prognostic significance of histological malignancy grading.

ML Talman, MB Jensen, and F Rank

Department of Pathology, Copenhagen County Hospital, Herlev, Denmark. mlmt@fa.dk

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	Talman, ML
	Jensen, MB
	Rank, F

MEDLINE ABSTRACT

Invasive lobular carcinoma (ILC) is the second most reported type of breast cancer in the Danish Breast Cancer Cooperative Group (DBCG). Several histological subtypes exist, with reports of different prognosis. The aim was to present the incidence of ILC in DBCG from 1977-2004, and evaluate tumours regarding diagnosis, histological subtype and grade, and relate to prognosis. Eight hundred and sixty tumours from patients with a diagnosis of ILC or ILC/non-ILC, who underwent breast cancer surgery in the period of 1990-1998, were evaluated. The impact of histological malignancy grade on disease-free survival and overall survival was analysed using a multivariate analysis adjusting for tumour size, hormone receptor status, axillary lymph node status and patient age. The incidence of pure ILC has risen from 5 to 12%, the ILC/non-ILC is constant at 2% of all reported breast cancers in DBCG. Most of the tumours were classical ILC grade II. The majority of the grade III tumours were among the non-classical subtypes, showing a statistically significant worse disease-free and overall survival compared to grade II, regardless of type. The prognosis was the same for grade I and grade II tumours. The number of positive axillary lymph nodes and hormone receptor negative tumours increased among grade III tumours. We conclude that histological malignancy grade has an independent significant impact on the prognosis of ILC, and it should be taken into consideration when planning the postoperative treatment in this group of patients.

Publication Types:

Journal article
Research support, non-u.s. gov't

MeSH Terms:

Carcinoma, Ductal, Breast
Databases
Disease Progression
Female
Humans
Incidence
Neoplasm Staging
Prognosis
Retrospective Studies
Survival

PMID: 17653904

MEDLINE data is licensed from the National Library of Medicine. Some material in the NLM databases is from copyrighted publications of the respective copyright claimants. Users of the NLM databases are solely responsible for compliance with any copyright restrictions and are referred to the publication data appearing in the bibliographic citations, as well as to the copyright notices appearing in the original publications, all of which are hereby incorporated by reference.

matic22 · November 2007

hello!

I have found a very good article about grading and ILC tumours.As I have already mentioned grade I and grade II classical lobulars have the same prognosis, but grade III non-classical lobulars have a significant worse prognosis.

I hope you find it interesting.Hear to you soon:)Bye :;)

nash · November 2007

My pleomorphic ILC was graded a 2. Should I have the slides reread, or have you seen pleomorphics as grade 2 before?

matic22 · November 2007

Dear nash!

No, you do not need to reread it, because pleomorphic can also be grade II. and it is good if it is so.So, be grateful to be so.:)Kind regards!

waterlily · November 2007

Hi Matic-

I was diagnosed with stage 3 grade 3 mixed lobulr/ductal in June 2005. 13/18 positive nodes. Lobular was of the pleomorphic type and the ductal had comedo necrosis. Not a good prognosis, but I am doing quite well and am happy for life I have scattered small bone mets and now have a 4cm solid mass on my ovary. I see the gyn oncologist on December 12th. I assume I am having a larapotomy to remove the mass, investigate and possibly stage if cancer. Do you have any resources on lobular mets to the ovary. I can't seem to find much information out there.

Thanks!

matic22 · December 2007

Dear waterlily!

thanks for asking. Well what I can tell you is that invasive lobular cancer tends to metastasize to peritoneal surface, and uterus and also ovaries but you know, you can also have benign teratoma of ovary, it is not necesarrilly to be a metastasis. Of course it can be also, but ovarian metastases of lobular carcinoma are well treatable if the cancer is hormone responsive,for instance, but as far as surgery is not done it is hard to say actually what this is. Do not concern about that!

If I find any interesting article of ovarian metastatis of lobular, I will post it ok?I am doing really a lot of research(almost every evening!) of lobular case reports, but I have to say that pleomorphic lobular is not so typicall to spread to ovaries, it is more common for classical lobulars.But of course in cancer there are no rules!

Kind regards and stay healthy;:)

Matic

waterlily · December 2007

Matic-

Thanks you for your hopeful response. My transvaginal ultrasound showed my left ovary to be 2.74x1.5x2.02 with doppler of RI=.13 and PI=.14. Thr right one was 3.70x2.86x4.66 with a solid lumpy appearance. The RI=1.00 and the PI was 2.48. I understand postmenopausal (or postchemopausal) ovaries are supposed to be small...hmmm. The doppler makes it sound like my smaller ovary actually has even greater vascularity than the large one. Ahhhh, it will be good to talk to the gyn onc to learn more.

PROGNOSTIC sig.of grading in ilc

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