P450-Arimidex-Antidepressives-Aromasin
Comments
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Helloooooo Ladies All.....
First to say that I passed my second year on 27 Sep (the date of my BC surgery). Today, I am writing with an update after my visit with the surgeon yesterday. Sorry for the UPPER CASE thing … and no, I’m not manic….I just so much want to be clear for the sake of others who may benefit from our sharing our collective knowledge and experiences….especially to relieve pain and depression.
A summary of “the problem is…”: My last visit was March past when I was biting her head off because I hated the side effects of Arimidex. I was also fed up with taking anti-depressives and their side effects. She offered a three-month vacation and on her exit from the office glanced back and said “but it isn’t the Arimidex”. Then what!!!! I’d like to know…..The oncologist disagreed with three months and agreed one month and to consider a change to Aromasin.
I set out on a quest from March until August between the following doctors … my GP, a rheumatoidologist and an endocrinologist. I kept abreast of most medical information here at “ask the expert” and our discussions boards of breastcancer.org
DESPERATE I posed the questions on this thread ….and, “when the student is ready, the teacher will come” …..
BEFORE returning to the course of anti-depressives that didn’t work the first time I took them….I TRIED the kind advise offered here … MAGNESIUM ….
DAY 18 ….. after first taking MAGNESIUM Pidolato. (Mag2) …. The change is so significant that I can say unconditionally that I will always take this suppliment.
My conversation with the surgeon yesterday …. I summarized the wonderful vacation from Arimidex …. Told her about the increase of my thyroid meds …. Discussed the weird labs for cholesterol and triglycerides that shifted back to “my normal” in a month’s time after the increased thyroid med ….and very excitedly I told her about the Magnesium and how it helped … she was very happy for me……then we discussed what “kind” of magnesium ….. I told her that according to this article glutamate and aspartate are “toxic” for depression and make it worse. She said “Mag2” and I shook my head yes and said that is what the pharmacist gave me … is it OK? Pidolato? She said ”Yes of course….and good for the muscles”. I asked is there any problem with Arimidex and this suppliment and she “No problem”. I said that was good to hear because if I couldn’t take the magnesium, I intended to stop the Arimidex and any other AI.
I showed her the article “Rapid recovery from major depression using magnesium treatment” Medical Hypotheses (2006), Eby G, Eby K. … where I found the information … pointed to specific sections and we chatted more about it. …then time for the physical exam.
I’m feeling “sore” and “tender” and she said to continue to massage the breast …. Use sweet almond oil … to help move the fluids that can build up ….
My husband was not with me for the first time of our visits since the surgery … I explained that he was recovering from his vitrectomy….but she was very pleased with my Italian and understood me perfectly. I was so thrilled at this as well. The doctor speaks English, but I help here during Race for the Cure and I need to speak in Italian to be helpful to the other women.
So, I bounced off the exam table … she set my next appointment for March of next year and sent me on my way….smiling!!!!!!!!!!!
I know this is a long story….but all of them are….and sometimes they need to be told…..I hope that someone here can reach to MAGNESIUM and find the same RELIEF….and isn’t that what we are here about?
Thanks again Rosemary and Kris Blinded by Science….. By the way, I’m looking for pasta made from whole grain wheat and I even have my husband convinced…he sees the BIG difference in me since taking the MAGNESIUM (much found in whole grain wheat). I did find pasta made with Cocao! Yes, really! Not sweet of course. I’m planning a meal with it and I’ll let you know how it taste. Wish I could invite you both to our dinner table to share in it.
Shiela … do see the endocrinologist … if the thyroid is hypo and without the correct dosage, the affects to the muscles and mental status is significant ….and interferes with metabolizing MAGNESIUM in our body.
Joan …. I don’t remember if you said that you tried this suppliment? But we both seem to be walking a similar path with the AI side effects and maybe the MAGNESIUM can help? We’ll talk again in NOVEMBER (wink wink)
Saluki…I HIGHLY recommend MAGNESIUM over anti-depressives….life is so much MORE again to me without anti-depressives. I am returning again to my writing group and I don’t feel that “internal brain ache push to do” that I had before…not to mention my body doesn’t mind moving again. I still do what I call “the Arimidex shuffle”, but it lessens and gives my brain room to think of something else beside pain!!!! I’m even thinking to get a dog who will need attention and exercise (scottish terrier or white terrier?)
OK then … hubby is better but not yet full sight…but we are hopeful all is well with a little patience. Oh, and yes....I will continue Arimidex as long as the Magnesium helps. -
Hi Blundin,
Up early catching some worms. I have peripherally followed your challenge and this thread and thought I'd congratulate you on a couple of things: first and foremost being your 2 (two)year anniversary! What a wonderful state of mind. Then there is the good news about DH, the fluency in a non native language, and of course your relief from the AI shuffle (as we sometimes fondly refer to it) with Magnesium.
But before you go for the day, for us would you post the full name of the Mag 2 (any american maker if you know of one) , the dose recommended, and tell us the reason for the word 2 after Magnesium and when do you take it in your pill day relative to your thyroid medicine. Thanks for this pragmatic information. I've been thinking about trying this.
I've enjoyed your posts and especially this thread, as it's near to my heart and muscles. Thank you for giving us (as well as Rosemary and Kris BBS who put you on to this stuff and who are so kind and insightful) the hope for less drugs and resolution of pain.
Have a great 2nd year anniversary day and wishing you many, many more!
Tender -
Hi TIOM …
Buon giorno! The best part of being a global community is that someone is always awake while someone else is sleeping. It’s like “standing guard” for the other. Thanks too for your comments. I hope that this thread has been of some help to many.
To answer your questions, I think that the links provided by Rosemary44 and Kris BBS were very helpful, so I repeated them here. But if you scroll back through the thread, both of these ladies offer more food for thought worth the read.
About the dosage, I take one envelope a day….in the morning about one hour after my Arimidex and Eutirox (thyroid). I take my vitamins, glucosamine MSM and Vit C after lunch. I drink Karkada tea at lunch as a diuretic to relieve bloating. My surgeon agreed the Karkada is a good idea. She advised that Magnesium can cause bloating.
“principio attivo: magnesio pidolato g 2,250 (corrispondenti a 184 mg di ione Mg++); eccipienti: saccarina sodica, acido citrico monoidrato, saccarosio, aroma di limone”
Rosemary’s research and link…
http://george-eby-research.com/html/magnesium-for-depression.pdf
Kris BBS’ research and links ….
http://www.drugdigest.org/DD/DVH/HerbsWho/0,3923,4023|Crataegus+oxyacantha,00.html -- this is a description for the hawthorn that I use for anxiety…effective, subtle … 10 drops in a little water on an empty stomach….recommended by my pharmacist.
http://www.mayoclinic.com/health/drug-information/DR202644 -- this listed information on magnesium, the various types, where in the world to buy it, etc. Mag2 is listed here
http://www.organotechnie.com/magnesiu.htm -- the company that makes magnesium pidolato – very good information—and I loved her comment “….to find it, go to the top”
I see my endocrinologist on Saturday morning … hopefully we close the loop on the questions of calcium type and D3 suppliment together with the Magnesium. It is my guess that the balance of the three requires monitoring, thus the package information for Mag2 recommended care when taking D3. I’ll learn more Saturday I hope. If not, I’ll find a endocrinologist at Gemelli Hospital and University to get to the bottom of it.
About the term “the Arimidex shuffle”…. I thought that I created the phrase here on the boards last year … I didn’t know it already existed....oh well.
Thanks for your encouragement and wishes.
Auguri tutti sempre (Best wishes to all as always), -
Hi Marilyn,
So glad that the Magnesium is doing the trick for you. That is one suppliment that I have taken all along and I've been taking twice as much magnesium as calcium unlike most of the gals on these discussion boards. I'm convinced it helps both in depression and musculoskeletal
issues as well as my RSD. The Sam-e really helped me with focus and I was really excited about it but unfortunately it caused crazy insomnia and urinary frequency and anxiety which continued after I stopped it. Thats really why I'm taking a low dose of the nortryptaline which has taken care of it.
I'm wondering if changing my type of Magnesium to Magnesium Pidolate
will make the difference ,however, it looks like the only place to get it is
Canada and then it is in powder form.
If someone has a source in the U.S. can you post it?
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Hi Susie,
Thanks for your support and comments.
About magnesium pidolate ... I think the info that Rosemary found in the translation was that the pidolate helps with absorption. I can't imagine that there isn't something in US that correlates .... the pidolate is probably a marketing thing more than a substanative thing.
My surgeon suggested that you can find the magnesium at any health store or gym. Fear not, we are all of us more the same than different....at least that is my experience.
http://www.globalcalcium.com/10magnesium_pidolate.htm
http://askwaltstollmd.com/archives/mg/240681.html
Best wishes, -
Marilyn,
You are correct, you will be on magnesium for the rest of your days. For myself, I can't go long without it anymore. I even take it along with me on vacations. I did not know about the bloating, see how well we help each other? I always feel bloated. I'll take your suggestion about the tea. B6 is suppose to help with bloating but at such a low dose that I take, it can probably use some help. Thanks
P.S. about the whole wheat pasta, I buy Racconto which is imported from Italy. Maybe you can find it there.
Tender,
I buy a powder form of it from NOW, magnesium citrate kind which I mix with 3-4 ozs of orange juice and take a low dose B6 with it. It doesn't mix with water too well. It must be absorbing well cause I can't go without it. It's best not to take calcium with it, wait a couple of hours at least.
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Actually Marilyn you've really hit on something here. The Magnesium
Pidolate is not a marketing ploy. It supposedly has some really unique
properties.
It is the only type of magnesium being used successfully in treatment trials for Sickle Cell Anemia dramatically reducing the number of painful days for these patients as well as reducing some of the abnormalities in their red blood cells.
I've been searching the online Canadian supplement and Pharmacy sites
but no luck except for a place called Goldpharma which didn't seem secure and left me very leary so, I did not order.
Guess I'll just have to stick with the type of magnesium I have for now.
Thanks -Marilyn and all you gals for some major sleuthing
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Hi Saluki,
That's very interesting info about Sickle Cell Anemia. Thanks.
Speaking for myself, taking this magnesium suppliment has been life changing to the positive for a change. I took it to one more level of test ....
Yesterday I worked in the garden...all day....hard....trimmed new growth from the orange trees, weeded around the roses, the trees, the rosemary bush, emptied earth from pots preparing for winter planting, sweeping leaves, trimmed vines, swept the terrace, mowed the lawn, bagged the clippings and leaves, loaded them in the car and took them to the disposal..... Granted, it's a little lawn! But this was work all day long.
In the past two years (post Arimidex) I would have been physically destroyed by this work...needing of NSAID and muscle relaxant for pain so to sleep. Last night, I intentionally didn't take any medication so to gauge the results.....today I feel the work in my arms, but it's that good ache feeling after a workout...... I "Arimidex Shuffle" for awhile this morning, but it shakes off faster....and I'm ready for another day. That's the best part....I'm ready for another day! And I'm smiling!!!
Best wishes to everyone here .... -
Kris BBS,
I took time to look at the web site you passed along earlier for the maker of magnesium pidolate. On their home page they state "no animal" and "no GMO". The fact that they do not use genetically modified products may explain why it is not available in US...trade issues? Or maybe there is another manufacturer for this product in US.
In any event, I sent them a "thank you" email.
Rosemary,
Thanks for the pasta reference. I haven't seen that specific name in this region but there are other whole wheat pasta advertising on TV. I'm certain that I'll find it. I asked at the pasta shop if they make "pasta integrale" but they said no. They make the pasta from cacao for a restaurant. We left our telephone number for when they make the next batch...she said probably 20 days. I'll try the health food shop.
I'm still very pleased with the results of the magnesium pidolate. This combined with Hawthorne for bedtime is perfect together.....especially less pain in the joints....I always try to dress in the morning without the help of anything to maintain my balance. It's my "intentional yoga" practice that is use during the day for my muscle tone. I noticed now that I can lift my legs higher to put on my jeans and without that striking pain in my lower back that before accompanied the movement. The little things in life that help to make it better. Best of all is that my brain is happy again...no more little disconnects or shocks from the anti-depressives. Maybe I'll need them at another time in life....but not today.
Yesterday I planted the winter pansies. I accidently broke an olive oil jug, so I turned it into a planter....always the alchemist.
Best wishes to all -
I thought more about the benefits of the magnesium. I'm not a medical researcher ..... but I thought that it might interest someone at AZ enough to check into it. So I wrote to them as well. The form in the "contact us" location is designed stated for use only for the US...this is why I added my residence to the information at the end of my writing. This is what I told them.....
<< I recently found significant relief from the SE of Arimidex with magnesium pidolato. I am writing to AZ because I want to share my experience with the researchers of Arimidex and the 40-50% of women who experience the severe joint pain SE when we take Arimidex. For a full explanation, please go to the discussion boards at www.breastcancer.org Community Support--thread entitled--"Hormonal Therapy"--Discussion entitled "P450-Arimidex-Anti depressives-Aromasin". It is vital to find relief from even one side effect during this therapy...and that pain is significant and real.
Respectfully,
Marilyn Blundin
I am a US citizen living in Bracciano Italy >>
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Bumping this up ... similar conversations recently
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Hi Marilyn
Hope you had a wonderful trip. I hope you missed our freezing rain and sleet of today and are back where the sun warms the bones!
I agree with you, Magnesium makes a big difference. Amazing how many processes magnesium is needed for. Ashame we can't get the Pidolate in the States so the Citrate form will have to do.-----Also, there are reports that D3 may help alleviate pain---Am taking 2000 mg. So, don't neglect the D3 in addition to the magnesium.
Going back on the SAM-e. It was wonderful for me mood-wise, cognitive functioning and pain alleviation---So much so that I thought I might have been able to go back to work--at least part time.
Turns out when reading the SE's of the Acetyl L-Carnitine/Alpha Lipoic Acid they were similar--and then I added Phosphatidylserine---Way too much of a good thing.-----So going back to the SAM-e without the other stuff.
Between the Magnesium Citrate and the SAM-e I'm hoping to make it near the end of the 5 years of AI in October-- (when I fall into the Donut hole again in May or June I may have to switch to Tamoxifen).
Pasta with Cocoa----Sounds Yummy!
PS. Totally had to give up SSRI's and Tricyclics. Could not tolerate the massive sweats or the crazy fatigue. My Docs are finally all in agreement on this.--no more of that stuff.
They have been very encouraging in trying this alternate approach.
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Hi Saluki!
Thanks for writing and yes ... it was quality time with the family on both coasts...a very good trip....which I don't think I would have enjoyed as much without the help of magnesium. I could actually feel myself smiling! I'm still amazed....permit me to sound like a broken record on this matter.
I found myself missing to visit these boards. The information is wonderful, but I missed to visit with everyone. It was good too that I stepped outside of it for awhile though. We speak so openly here....I was amazed at the stunned faces when BC was discussed. Our conversations here really are unique.
It's been a while since I read this thread ... since that time ....
Astra Zeneca and Paul Mason (mg.com) acknowledged my emails. And, after reading the article that you posted from the ASA, I sent a note to the chairman of Mayo Clinic. I'm unabashed to try and find an ear to listen to us...wholly....instead of in pieces. The hope is for other women walking beside us to find some relief from the Arimidex Shuffle ... the mental fog ... the resulting depression that steals our very precious moments.
Sorry that I couldn't visit some of you in person...my time with the family was full.
I found and tried the whole wheat pasta .... ummmmm, not exactly the same taste ..... I'll keep searching to find one that satisfies the palate....or a sauce that compliments better the taste of this pasta! I'm thinking mushroom sauce or fresh tomatoes and peppers....back to the drawing board.
The pasta made with cocoa ... not yet tried ... I'll visit the pasta shop soon now that we've returned.
Thanks for the D3 reminder ... I agree ... it's important.
Glad too to hear that the doctors are supportive of your "alternate" approach. I hope very much that as your body readjusts itself you'll find yourself feeling better.
Thanks for all of your posts...the research needs to be shared again, and again, and again.
Best wishes to all ..... as always -
I am new to this breast cancer conversation board. Here goes:
I have been cancer free for a little over four years. I would like to stop taking Aromasin and Effexor. I can't sleep while taking Effexor.
With summer coming up, I would like to enjoy myself for a while. Does anyone know the consequences of getting off Aromasin before five years and do you know what I should do to get off Effexor without all the side effects. Thanks Loody
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Hi, Loody,
With my first breast cancer, I took AIs for 4 years. I was stage 1, and my oncologist gave his blessing, saying I had most likely gotten all the benefit I would from it.
A year later, I had a new primary in the other breast, and now I'm on Aromasin.
I am NOT suggesting this will happen to you if you stop the Aromasin now or in a year or in 2 more years. It's really a very personal decision. Discuss it with your doctor (and congrats of being cancer-free for 4 years!!)
Regarding the Effexor...I presume it's the XR? You need to taper off this drug verrrry sloooowly! If you stop it cold turkey, you'll get nasty withdrawl symptoms of aches, chills, dizziness, and vomiting. I suggest weaning to the next lowest dose (if you're on 75 mg, then go to 37.5 mg a day for a few weeks. You may even have to alternate doses till you can tolerate the lower dose.) Then go to taking a pill every other day. Then every third day. If you get withdrawl symptoms then, it may be that your doc would want to put you on Prozac daily till you can stop the Effexor. Then you can just stop the Prozac, without the same withdrawl.
Effexor is notorious for insomnia. I liked what it did for my hot flashes and moods, but I switched over to Zoloft. It works as well, but I still can't sleep!!! Oh well. That's what Ambien is for, I suppose.
Good luck!
Anne
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Hi Loody,
Anne answered your question very well so there isn't much to add.
HT truly is a personal decision and not made easily as this thread and others support. I never took Effexor so I can't comment. But the withdrawl from Paxil (generic) was more than I ever want to go through again. I suspect that Anne's suggestion regarding this matter is very good.
It wasn't until I took magnesium that I felt relief from my issues. It is still helpful and I've been taking Mag 2 since mid September. I am capable of being cranky and I still have joint pain (arthritis)....but it no longer completely takes over my life and attention.
The weather has been damp and my joints are reminding me of that fact. I've taken Gladio (NSAID) a couple of times this week and it helped considerably. Soon the sun will be baking and we'll be storing up our Vit D.
BTW, I read that we need at least 50% of our skin exposed to take in a sufficient amount of Vit D from the sun.....hands and face only account for 20%.
My BC was caught early and I consider myself fortunate. I suspect that I'll continue to take the AI. However, I understand fully the issues raised about quality of life.
Best wishes to all....as always
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Hi Anne,
Thanks for the information. I guess I need to discuss this with my doctor. I am just tired of not being able to sleep at night. When I take Ambien or Tylenol P.M. I am so groggy the next day I can't get out of bed. Thanks, Loody
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Hi Marilyn,
Thanks so much for the information. I appreciate your and Anne's comments.
Spring is coming fast here in Benton, Arkansas. The daffodils are blooming and the weather is in the lower 70's today. God is in Heaven and will take care of us. I pray that cancer and medication side effects will be over soon.
Thanks again,
Loody
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