My new home--"The JOHN" --Help please!!!!

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saluki
saluki Member Posts: 2,287
Okay I tool myself off all the "Crazy Meds"---All my meds
and everything was much better.

Now I am 57 and some things just get weak with time or age---that being my bladder.

But I have a sneaking suspicion that all that stuff I was taking caused some urinary retention especially the Effexor.

Now, everytime I get up I've gotta run---and no sleep with 15mg of melatonin---up 7 times a night barely making it to the bathroom.

Can someone out there help me get a nights sleep?

Also why do they add B6 to melatonin---Are they trying to create a waterfall?

My last sublingual brand was without---Just curious.

Now looking for antihistamines that won't affect the live in hopes they will dry me out and let me sleep.

Any suggestions welcome.

Ps I had ovarian ultrasound February---Okay.

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  • TenderIsOurMight
    TenderIsOurMight Member Posts: 4,493
    edited March 2008
    Saluki,

    Normally, a urologic visit would be in order. To check for bladder prolapse, or a urethral diverticulum (out pouching). Or other. I take it your heart is pumping out o.k., your blood pressure is normal range (85-135), as these can contribute to night time diuresis or excessive voiding at night.

    Making a list of all of your medicines and herbal remedies, which I know from following your threads, you've made great headway in reducing to bare bones, and checking each to see the kidney effect, particularly for a diuretic effect, would be helpful.

    You know, estrogen depletion causes our urogenital tissue to loose turgor. So spills post voiding, or perhaps urgency prior to going, may all be traced back to this loss. This happens in menopause, even without hormones for BC, but I believe it is heightened for those of us who are on hormones for BC. I know I have developed similar problems.

    Now one thing you might do to sleep (as well as help your neuropathic pain, as I recall), is use the older drug amitriptylene (aka, elavil). This drug has anti-depressant actions, and helps incontinence because it acts as an anticholinergic agent on the bladder's nervous innervation, causing retention of urine and has sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters, which account for some of it's antidepressant activities as well as neuropathic pain relief.

    But there's always down sides to new pills, and this one may cause some constipation, heart rate alteration, and ?swelling amongst others. Yet it's relatively cheap, which is why pharmaceutical companies don't push it for neurologic pain IMHO, and it is effective.

    Hope this helps,
    Tender
  • JoanofArdmore
    JoanofArdmore Member Posts: 1,012
    edited August 2007
    Hi Susie,
    Came in to add that our pal Femara does crazy things to our bladders.Read the insert again. Urinary incontinance.(Bladder infections too.)
    Our old pal is making ME retain fluids to such a degree that I WISH it would let go of some.
    My onc has ordered a MUGA scan, and suggested I try Arimidex, to see if the edema would lessen.
    I am actually chicken.What if it got worse?It's your teaching that IAs get SEs that are worsenings of existing conditions.I've always been a sweller in the heat.(But THIS is rediculous!)

    I'm 65 and am used to getting up to tinkle at LEAST twice during my sleep.
    But 7 times a night is hell.
    Still-I envy you for losing all that bloat.
    Maybe it's buildup from all your crazy drugs over the years.Maybe a new, wonderfully skinny Susie is underneath and when you get rid of the bloat , your sleep will be great , and uninterrupted.I hope so!


    BTW--had my onc check-up.My tumor markers are 29!!!!They have NEVER been so low in my life!They STARTED at 36.
    Before I began taking Dr Weil's 1K vitamin D, they were at 41.
    Now...29~~:>)
    I believe them when they say vitamin D has cancer-fightkng properties.It is definately reducing my inflammations.(If only it would get rid of my edema now....)

    Sorry I couldnt be much help, but when something is caused by Femara...WTF are our choices?
    love, j

    PS--I hear you met Bethie.
    I have moved.It almost killed me, and I'll probably be in boxes for years.
    But.The place is HIGHLY air-conditioned, and gorgeous.
    Come see!!
  • Rosemary44
    Rosemary44 Member Posts: 2,660
    edited August 2007
    Joan,

    I don't think I'd change to arimidex because of edema. I swear I'm loaded with fluid. I watch the scale go up when I'm eating less. I'm looking for a water pill to take short term that doesn't make us lose too much potassium. Just something to break the water gain cycle.

    Susie, if your going so much you really need to keep your potassium level up there. 4.7 grams per day is the recommended amount. Of course don't hold the weight gain against me. That's a lot of bananas and O.J.
  • JoanofArdmore
    JoanofArdmore Member Posts: 1,012
    edited August 2007
    Thanks, Rosemary!You know how I value your opinion!

    Strangely, Lasix doesnt work for me.My onc tried it (WITH potassium) during Taxotere, and again now for the femara bloat.It will work great the first time.After that...less and less.Plus it makes me feel ..heavy-bellied.
    I DO hate the water gain.My shoes havent fit me in years.
    Edge recommended Dandelion, adding more as needed.Maybe I should add more!I'm stuck on 1 cap 3X a day.
    (But honestly.I probably need about 6 3X a day!)
    Thank you again!!I dont feel inclined to switch to Arimidex, have told my onc so.He's fine with that, was just trying to explore all avenues.
  • Anonymous
    Anonymous Member Posts: 1,376
    edited August 2007
    Kegels anyone? Seriously, I highly recommend them....for all of us. So even if you do need to pee alot, you'll have no problem controlling it. They have other benefits as well

    ~Marin
  • JoanofArdmore
    JoanofArdmore Member Posts: 1,012
    edited August 2007
    LOL Marin.That is the one part of my body I am still in control of.
    I just saw a t-shirt that says "Sometimes I pee when I laugh".
    It actually is not for me.

    PS I always had very good control over those muscles, and did kegels just to further improve my sex life.
    So maybe that's why it lasted?

    But then, even though you said Kegels ANYONE, my problem is not peeing a lot, but the reverse.
  • Rosemary44
    Rosemary44 Member Posts: 2,660
    edited August 2007
    Joan,

    I already like your Onc. But no one complains about water gain so how would they know? Out there is the perfect water pill. I know it exists, we just haven't found it yet.

    I do take B6 but not all the time and that's a diuretic but not enough to get rid of the real excess. We want more.
  • saluki
    saluki Member Posts: 2,287
    edited August 2007
    Tender-- going on a low dose of amitriptyline at night was exactly what I agreed to do if this didn't resolve over the next two weeks---Actually, I should say rather Nortriptyline,
    since I don't want another 40 pound weight gain. (I had that last time on Elavil)---I think its a wonderful medication and since they both cause urinary retention and sedation I could easily take a small dose at night and get some relief both in sleep and urinary frequency (not to mention pain relief).

    I just like the idea of being medication free and not taking anything that would effect my liver negatively----Those Tricyclics are metabolized via cytochrome P 450



    Well now I have a quandary. I was ready to have a little Femara vacation to see if that was the cause.

    Joan- I know its one of the rarer side effects ---but must I get every rare side effect in the book?

    My Achilles Tendons are still recovering from the antibiotic Levaquin. Who the heck associates antibiotics with tendon pain and tendon ruptures---So now anything in the Quinolone
    family is out for me even Cipro.

    But, now I find that one of the side effects of Sam-e can be urinary frequency and insomnia. I am having such success with it and since its one of the few things actually good for the liver--I'd hate to give it up. I'm going to cut back to 800mg a day instead of 1200mg.

    My docs were agreed that we'd experiment with the supplement route till October. I'd really rather not experiment with
    any more medications just to keep me on Femara for another year.

    Rosemary-OJ is out since I cut out the proton pump inhibitors--I can't handle citrus anymore however; I can handle bananas and an unlikely source of potassium---potatoes; and of course my favorite breakfast food --sardines. lol
  • saluki
    saluki Member Posts: 2,287
    edited August 2007
    Yes, I think definitely my next move will be cutting back on the Sam-e to 400 mg a day or every other day. What's one more experiment?---I've been at a therapeutic dose
    for almost three months, and think I can get just as much benefit at a lower dose. Also taking it at breakfast wouldn't hurt. I certainly wouldn't have taken Effexor before bed.

    Wish me luck.
  • rubytuesday
    rubytuesday Member Posts: 2,248
    edited August 2007

    I'm using SAM-e too but take it first thing in the morning. Mine says to take it on an empty stomach. I am currently using 300 mg. daily. I take 200 first thing and then my Glucosamine/Chrondroitin/MSM now has 100mg in it too. I do take that with breakfast so I'm not sure how much benefit I'm getting from the SAM-e. Best wishes!

  • saluki
    saluki Member Posts: 2,287
    edited August 2007
    Yes Ruby --To get the most bang for the buck you are supposed to take it on an empty stomach. How much bang for the buck that I want at this point is yet to be determined since I was taking 400mg three times a day.

    Since one of the few side effects attributable to it is gastrointestinal and since I have GERD I've been avoiding that one.

    Next time I order, I may use the Jarrow brand since it is also enteric and comes in 200mg. That way I can control the dose more easily. I see they also put out out a formulation with glucosamine. I wonder what the size of that pill is?
    How big is your pill?
  • saluki
    saluki Member Posts: 2,287
    edited August 2007
    Eureka! It was the Sam-e. I cut back on the dose and I've stopped running. Hopefully the insomnia will ease up as well.

    I hope I can maintain my focusing capability with the lower dose. It was doing such a great job. I'd rather not have to take anything else.
  • rubytuesday
    rubytuesday Member Posts: 2,248
    edited August 2007

    YEE HAW...glad you found the cause. Now if you can just make the adjustment work for you!! Mine are capsules....sort of a larger size capsule. I guess with Glucosamine/Chrondroitin/MSM/SAM-e, they have to be a good size. I do like the combo though. Best wishes!

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