Taxotere side effects?

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  • daphne98
    daphne98 Member Posts: 22
    edited August 2007
    Hello Ladies
    I always read with great interest and sympathy your posts. It a big source of support for me. I wanted to ask if any of you has received (or plan to receive) more than 6 courses of taxotere, alone or in combination with other drugs. My initial tx plan was to have Taxotere and Cyclophosphamide (TC) for 4 or 6 cycles (I am having my 3 tx today), but now I am in discussions with my doctor to stop it at 4 cycles and add another 4 cycles of Taxotere and Carboplatin which seems to be beneficial for triple negative BC patients like myself (at least it seems to help significnatly some of us). Although I am doing well on Taxotere so far, I worry about having 8 doses of the drug in total. Any experience, views or info ?
    Many thanks.

    Warm regards to all of you.
    Daphne98
  • purplehaze66
    purplehaze66 Member Posts: 136
    edited August 2007

    daphne, I had 6 TAc treatments. Taxotere Adriamycin Cytoxin. the treatments were cumulative. I felt that the side effects were stronger on the last 2. but bearable. I wasn't working during my treatments because I had 1 every 3 weeks and the 1st week was bad the 2nd I would start to come around by the third it was time to start all over. my counts were low, red and white. I work with public and just couldn't be around people, it was during the winter and people would always come in with colds and I was afraid I would get sick. I know everyone is different but i did experience different side effects each time. towards the end I felt weaker and exhausted.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited August 2007
    Daphne98
    Please let us know how you adjust to the change. I was planning on having my 3rd TC next Friday, but will be changing my onc Monday. I am not sure if he'll change the cocktail or not. I had no input into what my other onc did, it was more like an order. I was orignially to have 3 treatmetns but to my surprise discovered, she actually ordered SIX! When questioned about this all I got was, "We'll see".
    Like you, I have had one terrible week , then a getting better week, and when the third week came around it was getting the house ready for another 2 bad weeks. In fact this is day 12 of treatment #2. I got out for the first time yesterday.
    My son forced me to go to Starbucks with him, but I just couldn't bring my self to have a latte. There's something about this darn chemo that has turn me off from not only coffee but almost everything editable.
  • Cynthia1962
    Cynthia1962 Member Posts: 1,424
    edited August 2007
    Jean - pain in the rib cage could be the Neulasta or bone pain from the Taxotere. I had a lot of strange aches and pains after my lumpectomy, too. I wouldn't panic unless it gets much worse or very painful. I'm sure your new onc will answer any questions you have. If they want blood work, it sounds as if they're better than the one you have now.

    Cynthia
  • twink
    twink Member Posts: 1,574
    edited August 2007
    Jean,
    I'll see if I can find the earlier postings. I remember the woman posting a pic...her head was covered with little read bumps... (not just a few pimples). I wouldn't worry unless it's widespread.

    Are you getting Neulasta shots? They can cause pain in the chest area.

    You know...stress can cause these symptoms too. Seeing your new onc on Monday, along with the bloodwork, should set your mind at ease.
  • twink
    twink Member Posts: 1,574
    edited August 2007
    Hi Daphne,
    I only had 4 Taxotere (dd). I'm now on Carboplatin (4 of those scheduled). Started this roller coaster ride back in February with 4 AC (dd).
  • Traci40
    Traci40 Member Posts: 41
    edited August 2007
    Hey Ladies,
    How's everybody doing? Tomorrow will be day 7 since my third and last Taxotere....thank God....and I have been having a lot of back pain for the last three days. I felt better today...thank God again....but here I sit in my bed wondering if I can handle another Hydrocodone.
    I don't have the pimples on my head but, I do have blotches of red skin on my arms and legs.
    And, these tissue expanders are driving me crazy. I get like pinches of pain in my chest. I'm pretty sure it's from the expanders and not the Taxotere but, who knows.
    I go for blood work tomorrow.
    I hope you girls are all hanging in there.
    Oh yea...and my mind is gone. I can't remember anything. I made a pretty bad mistake with work that I'm not sure how the customer is going to handle. I would have never made the mistake before. Never. It's like...back to the basics stuff.
    Anyway, gonna browse around.
    Cynthia, aren't you done now??
    : ) Take care y'all.
    Traci
  • daphne98
    daphne98 Member Posts: 22
    edited August 2007
    Hi Twink
    Thanks you for your reply. I do appreciate it. May I ask if you take 4 courses of Carboplatin alone, not in combination wirth other drugs and if yes do you know the dose ?I have heard that Carboplating has minor side effects, is it true ? Also from some research papers I read it seems that platinum agents work well only for triple negative BC that have BRAC mutations, or at least they have dysfunction of the BRAC pathway, even if proper BRAC mutation of the familiar phenotype are not present. I guess this research is not well established in correlation with the clinical findings and the apparent lack or objectively measurarable histopatholopgy biomarkers. I would appreciate if you tell me more about your experience of if you have more relevant info.
    My best wishes for your fight with BC. I really hope it will go well. It is a hard rollercoaser, but hopefully there is light at the end of the chemo tunnel. Warm regards
    Daphne
  • talktome
    talktome Member Posts: 4
    edited August 2007

    I just found replies to my itching question ! I get confused with all the different threads, never sure where to look. Since a lot of you itch later in the cycle with taxotere maybe I shouldn't be concerned. My son looked at me this eve (7 days after chemo) & told me that I was covered in hives- that's how it is with me,once I finish the steroids the hives come. My onc said to take benadryl. I just don't want it to get worse each TC. I was to have 4 TC's but new research came out,( which I don't have), in favor of 6 which I'm scheduled for. I have questions there but another time since I just read about Cynthia having such a bad final chemo experience. So sorry that you had to go through that & that you kept going was unbelievable. You must have great faith in your doctor. Thanks for replying to my other first post!

  • Cynthia1962
    Cynthia1962 Member Posts: 1,424
    edited August 2007
    njsyb - thanks for your concern. I still can't really wrap my mind around it, but like my nurse said, it happens. Well, I'd been waiting for the other shoe to drop, so maybe this was it and I can relax now. Geez, I hope so.

    Hives? Ugh! I hope the benadryl helps. That must be miserable.

    Traci - how was your blood work today? I hope your back pain is letting up. I hear ya on the brain challenges! I can't believe the stuff I've been doing in the last couple of days. And I have so much fatigue. I know I'll get through it, but I want to feel better now! lol

    Cynthia
  • SueB46
    SueB46 Member Posts: 74
    edited August 2007
    I had my first Taxotere a week ago today (after 4 A/C), and I can join the club of those who feel worse with this one. Numb fingers, watery eyes, thrush, bone pain that won't quit. Does anyone take anything besides pain killers? Would Glutamine (sp?) help?

    Sue
  • Harley44
    Harley44 Member Posts: 5,446
    edited August 2007
    Cynthia,

    I remember that you said you had the numb, tingling fingers, etc... but it was at first, right after the tx? Well, I am getting it NOW, almost three weeks later, when it's time for my ntext tx. This concerns me, since you said that it went away, after a few weeks. I wonder if it means that for me, it will be a permanent se... Gosh, I sure hope not!

    HARLEY
  • sharebear
    sharebear Member Posts: 332
    edited August 2007
    Ladies,

    I've got a new one for the neuropathy in the legs. My dr. has me taking vitamin B6 100 mg twice daily. It seems to be helping. I don't want to take pain medication because I already have a constipation problem due to IBS. It took 10 treatments for me to get the tingling hands but I've got them now. My dr. told me to hang in there. Only 2 more weeks!

    Sharon
  • Cynthia1962
    Cynthia1962 Member Posts: 1,424
    edited August 2007
    I mostly get the tingling in the first few days after tx, but I did get it later as well. I used l-glutamine the first 2 txs, but stopped when it seemed it wasn't going to get worse. If you haven't tried it, it's worth a shot. You can buy it in powdered form and the recommended dose is 20-30 grams daily. I've also been taking the B6.

    Cynthia
  • Harley44
    Harley44 Member Posts: 5,446
    edited August 2007
    Cynthia,

    Thanks! You take L-glutamine? and B6? Ok, I'll try it. I don't want this to be permanent!

    Congratulations again!! I am so jealous!

    HARLEY
  • ilovejesus
    ilovejesus Member Posts: 35
    edited August 2007
    SueW46,
    For the thrush 2 things. Ask your doctor for Diflucan. Don't wait until the thrush starts. Just start taking it a day or two after treatment. Also get pro-biotics. Larger grocery stores with health food sections or health food stores carry it. It's about $30 a bottle but well worth it. Get the stuff that has to be refrigerated. It's the most potent.
    God bless
    Dorothy
  • tos
    tos Member Posts: 376
    edited August 2007
    I just finished taxotere number 5, have one to go and for the last couple of weeks I have noticed my fingernails very tender and sorish but I haven't lost any. Anyone have nail problems? This may have been answered, I'm so out of it from this chemo my brain is mud.
    I'll really be glad to get that last tx, I've had enough of this taxotere, just keeps me down w/all the dizziness.
  • Cynthia1962
    Cynthia1962 Member Posts: 1,424
    edited August 2007
    Pam,

    Congrats on almost being done! My nails have been tender since my 3rd tx, but they haven't discolored or lifted up so I don't expect that to happen. My onc said the tenderness is a common se. Hang in there, you're almost finished.

    Hugs,

    Cynthia
  • Traci-----TripNeg
    Traci-----TripNeg Member Posts: 2,298
    edited August 2007
    Hey Ladies,
    My right big toe nail is starting to look a little funky which is really ticking me off and....my eyebrows keep getting thinner and thinner! I barely have any left. What's up with that????????
    I have a 5:00 shadow on my head though! WOO HOO!!!!!!!
    Back pain....all but gone. I'm sure it would be gone if I would get my fat, lazy a$# on my treadmill!
    I gotta get up the gumption to do that. 3 lbs heavier at my weigh in today.
    As I type this, I'm eating Tostidoes.
    I'll snap out of it. That hysterectomy I have coming up should help....lol.
    Hope you guys are all hanging in there!
    Hugs, Traci
  • twink
    twink Member Posts: 1,574
    edited August 2007

    I finished Taxotere May 24th. My baby toenails fell off in June. Several of my fingernails became discolored (two with black marks, the others orangey) in July. Several fingernails and toenails are lifting and I think the big toenail is coming off. In my case the SEs didn't occur during Tx. As with Traci, my hair started to come back during Tx.

  • Cynthia1962
    Cynthia1962 Member Posts: 1,424
    edited August 2007
    Wow, Twink, how surprising to have your nails have problems so far after tx. I guess I won't know about my nails for awhile. Oh, the joys of chemo...it just keeps on giving.

    Cynthia
  • twink
    twink Member Posts: 1,574
    edited August 2007
    Quote:

    Oh, the joys of chemo...it just keeps on giving.




    Oh, so true...giving and giving and giving...like an Eveready battery... blah.

    Good luck Cynthia.
  • erika-canada
    erika-canada Member Posts: 142
    edited August 2007
    HI: JUST WANTED TO SAY MY LAST TAXOTERE CHEMO WAS APRIL 16. STARTED LOOSING NAILS 3 MONTHS AFTER. LOST 6 SO FAR AND LOOKKS LIKE ANOTHER 3 GOING. IN FACT ON BABY TOES, AM NOW LOOSING THE NEW ONES AGAIN WTH??? THESE ARE ALSO THE 3RD SET OF EYEBROWS, IF THEY DON'T STAY....I GIVE UP.

    FINISHED MY LAST RAD A WEEK AGO; HAVE ZERO ENERGY. WHAT A HORRIBLE BXXXX OF A DISESE THIS IS.

    WISHING YOU THE BEST AND MANY HUGS,

    ERIKA /CANADA
  • bomber410
    bomber410 Member Posts: 564
    edited August 2007
    Hi ladies,

    I've had sore fingernail beds since my second of four taxotere treatments. I've had 3 treatments total and one more to go. The nail beds are becoming more discolored. The nails are tender when trying to untie shoes.

    Cynthia, if you didn't have any of this, you may not lose any nails. That's a good thing.

    What's maybe a bit frustrating to me is that I don't notice any of this with my toenails yet. I wouldn't care if I lost them because I can wear shoes and socks to cover my toes. However, the rate I'm going with the sore fingernails and discoloried nail beds, I'm likely to lose all my fingernails.

    I have one more taxotere treatment on September 7.

    As for my hair, I've head the stubble on top since my hair fell out but no new growth yet.

    It's always interesting to compare and share what we are going through.

    Debbie
  • Anonymous
    Anonymous Member Posts: 1,376
    edited August 2007
    Okay, now I ever more frightened. Today is my last Taxotere before mast. My new onc wants to change my treatment after surgery from TC to TAC. So far I haven't noticed "much" of a change in my nails, although a couple have flaked slightly. Do you think the reason our finger nails are more effected than our toes, is because of all the handwashing?
    I have not rebounded much from my 2nd TX. FIrst time it took about 5-6 days, but this time I still feel badly. I have a pacemaker and had it checked Monday. It has gone off 165 times in the last 80 days. Under normal circumstances, non-chemo, it never goes off. I hope this doesn't mean I have developed an alergy to the drugs.
  • erika-canada
    erika-canada Member Posts: 142
    edited August 2007
    HI: I'M TRULY SORRY IF I'VE SCARED ANYBODY ABOUT NAILS COMING OFF MUCH LATER AFTER TAX CHEMO. I NEED TO CLARIFY. THIS DOES NOT HURT BECAUSE THE NEW NAIL GROWS UNDER THE OLD ONE. WHEN IT'S TOTALLY GROWN, THE OLD ONE COMES OFF. I, TOO, IMAGINED NO NAIL AT ALL AND PAINFUL.....NOT SO. MORE OF AN INCONVENIENCE, THAT'S ALL.

    ANY QUESTIONS, PLEASE PM ME.

    SENDING MANY HUGS,

    ERIKA /CANADA
  • Anonymous
    Anonymous Member Posts: 1,376
    edited August 2007
    Erika

    Thanks so much for the clarification. I was picturing me with no nails on my hands and feet...just the bare nail beds. Well off to tx #3, last before my surgery. I guess htat means Iam half way thru my chemo. I will be having TAC after surgery but I don't know how many tx.
  • booklady
    booklady Member Posts: 70
    edited September 2007
    Hi ladies, hope you all can help me. Just had my 1st taxotere treatment on Tuesday and am wondering what to expect. I only need 2 because I switched from Taxol. I'm having some tingling in hands (already had some), sore throat, muscle ache, nasty taste in my mouth (had hoped that was gone when done with AC) and hoping that the worst has kicked in already.

    Do I have anything else to look forward to? I've done great so far, and with only 1 treatment left really no reason to complain. It's just that there's something new all the time re SE's . My head always seems to be out in never-never land and I used to be such a creature of routine. Oh well............
  • tos
    tos Member Posts: 376
    edited September 2007
    This has really been an interesting and helpful thread, I'm glad we've gotten together to share thru our Taxotere times.
    I am feeling better, day 10 from last chemo so it should get better. One more in two weeks. Not so dizzy today but lets weak, think I need to make myself get up off my fanny more. lol
    That is interesting that some of you have problems after treatment! Oh boy well we have to do what we have to do to get rid of this bugger. We can do it.
  • LMJP
    LMJP Member Posts: 9
    edited September 2007

    Get the right information for you and your body from medical team, and seek as much opinion as needed on viable alternatives. Get your family, friends and any psych support on board too - and don't forget you've got us!! What works for others may not work for you. I have got through with Neurontin for muscles, and Diazepam for the eye twitch (plus other stuff) - all from my general practitioner, who worked in oncology as an intern. Always remember that this is YOUR body and YOUR cancer. We can support, but everyone reacts to a lesser or greater degree to every chemotherapy drug - after all, look at what they are designed to do~!! xx

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