IP-6 Inositol Hexaphosphate

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Hi all,
I have searched this site for a thread on this and cannot find one. If it has been discussed at length already please direct me to it.
Is anyone taking this supplement? Opinions please. The research that I find on it says that is works synergistically with Tamoxifen, which I am currently taking.
Mimi

Comments

  • saluki
    saluki Member Posts: 2,287
    edited July 2007
    Mimi
    BBS mentioned 5-htp in the Sam-e thread. Do you want to take this for depression because 5-HTP converts in the brain to Serotonin?
    Maybe someone else can help you with the Tamoxifen interaction
    but here is some info on 5-HTP

    Keep reading to the bottom even though some of it looks like an advertisement---Some of the info is woven through the whole page.
    http://www.raysahelian.com/5-htp.html


    This is something I ran across that bears further investigation.

    One word of caution:
    5-HTP has been associated with eosinophilia myalgia syndrome (EMS), a rare and potentially fatal blood disorder, although it isn't clear whether 5-HTP actually contributes to developing the disorder. In addition, people who take antidepressants or herbs and supplements with antidepressant effects (such as St. John's wort and SAMe) should avoid 5-HTP. Talk to your doctor before taking 5-HTP.

    Susie
  • rubytuesday
    rubytuesday Member Posts: 2,248
    edited July 2007

    Mimi, I take it and have for the last 9 years (since my first diagnosis). I have read the research and think it is a good supplement to take. FWIW, my second diagnosis was a new primary which was a rare bc and was not aggressive. Best wishes!

  • AggieFan0606
    AggieFan0606 Member Posts: 20
    edited July 2007
    Saluki- I think we are talking about two different supplements. I am not taking this for depression. If you google IP-6 there is a lot of information on the benefits of taking it. I really haven't found much negative on it.
    Ruby- I appreciate your response. Possibly this supplement helped to keep your 2nd primary from being aggressive. I hope that all is going well for you.
    Mimi
  • saluki
    saluki Member Posts: 2,287
    edited July 2007
    Mimi-You are right---another thing to blame on Chemo brain.
    My information processing ability is nil. Sorry for the confusion.

    Susie
  • AggieFan0606
    AggieFan0606 Member Posts: 20
    edited July 2007
    Saluki- I plan to use the "Chemo brain" excuse for the rest of my life. I figure if we have to endure it then we deserve something out of it!
  • BlindedByScience
    BlindedByScience Member Posts: 314
    edited July 2007
    Saluki, you were probably cross-wired between 5 HTP and IP6 because IP6 hexaphosphate also has activity in affecting neurotransmission.

    IP6 is widely promoted as anticancer supplement but some people experience strong side effects, so be aware if you take it that you may have fatigue. IP6 is also known as phytate. It is commonly found in plants, so here’s one reason a mostly vegetarian diet may be helpful to us. The blurb below explains the possible fatigue link:

    http://www.vitacost.com/Healthnotes/Supp/IP-6.aspx
    “Phytate in foods has been associated with reduced mineral absorption.1 In particular, significant interference with iron absorption has been reported.2 People who are iron deficient should talk with a doctor before supplementing with IP-6. Even for those who are not iron deficient, if IP-6 supplements are taken for more than several months and fatigue —a possible symptom of iron deficiency develops, a doctor should be consulted. How much iron supplementation (if any) should be used to counteract the iron-depleting effect of IP-6 varies from person to person, though many people are likely to not require such supplementation.”

    Phytate or IP6 has antiangiogenic properties—mostly it helps prevent tumors from growing by limiting the tumor’s ability to stimulate the growth of new blood vessels. Without an ever-increasing blood supply, the tumor cannot get sufficient food and remove wastes fast enough to support its growth. Other supplements also provide antiangiogenic activities, for example, grapeseed extract. Here’s an article on the antiangiogenic properties and as well as a brief description of other properties of IP6 (antioxidant, aid in neurotransmission):

    http://carcin.oxfordjournals.org/cgi/content/full/carcin;25/11/2115
  • AggieFan0606
    AggieFan0606 Member Posts: 20
    edited July 2007

    Great info, thank you. I have recently starting seeing info on "iron" and its relationship to cancer. I actually was diagnosed years ago as having "high iron of unknown origin". I tested negative for hemachromatosis. I will supplement with IP-6 and keep a heads up on the fatigue factor. Maybe this supplement will help with my iron issue. Worth a try....

  • BlindedByScience
    BlindedByScience Member Posts: 314
    edited July 2007
    Mimi0606--were you premenopausal at the time you were tested for hemochromatosis? Did they just check your blood level of iron or do a genetic test? What I'm wondering is, if they only tested for the blood level of iron and you were still at a time in your life where you lost iron through menstruation, it may be possible that you do have one of the forms of hemochromatosis and it will become a problem for you once you are menopausal and iron has a chance to build up.

    There are many good websites on this condition, but I’m quoting one below:

    http://www.irondisorders.org/Disorders/Hemochromatosis.asp
    In classic hemochromatosis, the iron build up is slow, usually taking 25-30 years before observed damage can be detected. In clinical practice, HHC/iron overload is more often seen in male's in their mid to late fifties. For this reason HHC has acquired the mistaken identity of an older male's disease. HHC can be present in females, especially those who no longer menstruate.
  • Hmark
    Hmark Member Posts: 1
    edited July 2007
    Yes I agree with saluki about 5 htp. However more information about 5 htp can be found at 5-htp website.
  • SoapMaker
    SoapMaker Member Posts: 157
    edited August 2007
    I took it faithfully for a number of years (the powder). I ran out a few months ago and just haven't gotten around to buying any more. The further out you get with this disease, the more you start sloughing off. I really need to get back on top of everything. I just get so tired of taking so much stuff.

    I read Dr. Shamsuddin's book on it and it was very interesting.

    ---------------------------------------------------------
    Where is the cure
    www.truefacesofbreastcancer.org
  • KEaster
    KEaster Member Posts: 18
    edited August 2007
    Mimi -

    How much IP-6 do you take each day?

    My Mom told me about this supplement and said you need to take 8 grams/day to be effective against cancer. That means I have to take 10 tablets each day - I try to get them all in, but some days are better than others.

    I have only been taking IP6 for a few weeks, so I don't expect to see any results for awhile.

    Do also take IC3? It's also supposed to have great anti-tumor properties.

    Kristina
  • AggieFan0606
    AggieFan0606 Member Posts: 20
    edited August 2007
    Yikes! I don't take near that amount. I have the Swanson Brand capsule form. One capsule is 500 mg. Kristina, where did your Mom hear that you had to take 8 grams/day?
    Would it be better to take this is in the powder form that Cin54 talks about? What is IC 3? Guess another thing to google.
    Thanks for your feedback,
    Mimi
  • KEaster
    KEaster Member Posts: 18
    edited August 2007
    Mimi -

    My Mom found this information in a book called "90 Day Immune System Makeover" by Janet Maccaro. The information about IP-6 is on page 184.

    Here's a link to the book on Amazon.

    http://www.amazon.com/90-Day-Immune-System-Makeover/dp/0884196925

    Kristina
  • SoapMaker
    SoapMaker Member Posts: 157
    edited August 2007
    Quote:

    Yikes! I don't take near that amount. I have the Swanson Brand capsule form. One capsule is 500 mg. Kristina, where did your Mom hear that you had to take 8 grams/day?
    Would it be better to take this is in the powder form that
    Cin54 talks about? What is IC 3? Guess another thing to google.




    8g is for people with active cancer. Half of that is for maintenance. I take/took one scoop per day.

    ----------------------------------------------------------
    Where is the cure
    www.truefacesofbreastcancer.org
  • Jellydonut
    Jellydonut Member Posts: 1,043
    edited May 2008
    I looked into this five years ago at initial diagnosis. I too read the doctor's books about this product.  Anyways, I did buy it and tried it. Unfortunatly, it gave me severe headaches and I stopped it quickly. As I recall, it was quite expensive, about $60.00.
  • Woolmer
    Woolmer Member Posts: 5
    edited November 2008

    Hi Everyone. I have some information about IP6-Inositol-Hexophosphate which I want to share with you guys.

    IP6 Inositol Hexophosphate

    Jarrow formulas IP6 contains 500 mg of purified Inositol Hexaphosphate (IP6) from rice bran extracted in Japan. IP6 is a phosphorylated form of inositol commonly found in fiber-rich plant foods. IP6 supports immunity and cardiovascular health by enhancing Natural Killer (NK) cells and chelating reactive iron to protect against damaging hydroxyl free radicals.

    I hope this information will be useful for you guys.

    Here is the link I found:-

    http://www.nutrovita.com/1736/jarrow-formulas/ip6-inositol-hexophosphate.htm

  • lanihardage
    lanihardage Member Posts: 190
    edited January 2009

    Here are some medical research articles on IP6 and inositol. My oncologist recommended I take it for prevention. It has been shown in lab studies (not people) to reduce the prevalance of several kinds of cancer. In a clinical trial, it has been shown to enhance the anticancer effect of conventional chemotherapy, control cancer metastases, and improve the quality of life. 

    http://jn.nutrition.org/cgi/content/full/133/11/3778S

    http://www.worldwidehealthcenter.net/articles-355.html 

  • Bmarie
    Bmarie Member Posts: 129
    edited May 2009

    I know this is an old thread, but is anyone still on IP-6 & Inositol? I bought some and want to start it...Dosage for active cancer? 4-8 g?

    Any side effects?

    Thx so much!

  • Grace61
    Grace61 Member Posts: 53
    edited May 2009

    Hi BMarie, 

    I would like to know also as I just began taking it Thursday. I was instructed not to take it until at least 45 minutes before or after eating or taking other supplements. That takes a bit of juggling but so far so good. I am taking 7 grams.

     Please let me know how things are going for you.

    Grace

    Who just realized the true meaning of "the gift that keeps on giving" 

  • Bmarie
    Bmarie Member Posts: 129
    edited May 2009

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