Anyone stop Aromatase Inhibitor - Stage 4 HER2+/E+

Hello-

I was wondering if anyone who is HER2+/estrogen+ has successfully gotten off of an aromatase inhibitor but stayed on Herceptin without recurrence issues?

I am at my wits end with Letrozole. It has literally made me crazy and I have gained 55 pounds since I have been on it for 4 years now. Most of the weight I have gained in the last year, even if I starve myself it doesn't budge. I am not sedentary. My oncologist and internist have both told me that weight gain is part of the side effects of letrozole and I will have to work 5 times as hard as a normal person to try to get the weight down. I am on ridiculous amounts of anti-depressants and still struggle (was diagnosed with PTSD and clinical depression right after my mastectomy). I was diagnosed stage 4 from the get-go and have been NED for 3.5 years. I get Herceptin maintenance treatment every 3 weeks.

I am just tired of quality of life issues. Not sure it is worth my mental and physical health being on the aromatase inhibitor. There are studies that show how not having estrogen is very hard on the brain because it has a lot of estrogen receptors. I read about one lady who is documented as going psychotic on Letrozole and had no history of mental illness until she got on it, and I feel like that is exactly the boat I am in. The depression is suffocating and debilitating.

I have lost pretty much everything because of this cancer (my marriage, ability to have children, breasts, total hysterectomy). I was diagnosed at 36 and am now 41. My outlook on life is terrible - I just try to get through each day. My support system is my mom and dad, but my sister has been terrible and thinks I should just "get over it already" and we don't have a relationship because I moved back home to be near my family after my marriage imploded and she says that I ruined her life when I moved home because she says our mom spends too much time with me and is also jealous that her kids love me and has even kept them away from me just to be cruel. She and her husband also get pissed off when I visit their church because it is their church and I should find my own. I have been hoping my life would improve at some point, but it just isn't. I can't even find the silver lining in anything anymore, and I used to be a very positive and happy person.