How are people with liver mets doing?

MO called me with MRI of liver report. Immunotherapy is not working, there is an increase in the size of the liver lesions. I have gone through 15 lines of treatment so far. My choices are limited.

MO suggested Eribulin starting next week. I know some of you were on this drug for a long time - was it tolerable? What was the worst side effect you had? Has anyone tried icing for peripheral neuropathy and hair loss? Any tips and suggestions to deal with the side effects would be welcome.

Hi S3K5. I'm sorry to hear about the progression. I have just started Eribulin - second infusion of the first cycle tomorrow. I found the first infusion very tolerable with no nausea or issues. Biggest thing for me is fatigue which I really felt from about day 3-5 and then improved. I also had headaches which are a known SE but they weren't debilitating and, on day 4, woke with some achiness which again, is manageable. I know some have premeds but they don't do that here and I haven't needed them. The chemo nurse indicated that most people who have hair issues have thinning, not total hair loss although that's not something that I am particularly worried about. As to neuropathy, I haven't experienced it yet. While I've been on many treatments my time on Taxol was short and five years ago. I was on Vinorelbine for three months which can cause neuropathy but so far so good.

There are some that have been on Eribulin for quite awhile. Wishing you success on it.

NicoleRod , sorry to hear about your SEs with Eribulin. Are you on the same drug or has your MO switched you to a different drug? Hope you get on the treatment that is tolerable.

Sadiesservant , I am glad you didn't have overwhelming side effects after your first dose. Hope your other doses are equally easy. We'll keep each other updated on the Halaven thread.

Moth, thanks for your response. I go to Sloan Memorial Kettering Cancer center and the staff shortage is all over. Wait times are longer but my MO is kind of aggressive in terms of treatments. I hope you start Trodelvy soon and it does wonders for you.

Has anyone heard from Grannax or AlabamaDee?

S3 I stopped Eribulin back in Nov or Dec...I had 2 infusions of Trodelvy in Dec...then got covid and have not had any treatment since. So right now we are suppose to go back to Trodelvy....

sent you a PM, candy

Nicole- I have not PM'd her. You go ahead and see if she responds. From what I can tell, she has not logged onto BCO since Nov.

Hi all REF: Grannax...

I wrote to her and she asked me to share this with you all:

I found out the trial is not working so I told them I would not participate anymore. Also, I had the talk with my primary oncologist. I decided to do no more TX.

I am going to have a PleurX put in. The procedure is scheduled for January 20

Nicole,

Thanks for the info about Grannax, even though it's not great news.

Rosie...Dee is doing ok I have been in touch with her via email.

Thank you Nicole for letting us know about Grannax and Alabama Dee. I respect everyone's wishes for their future, but I do wish that they would just post a "goodbye" post that they are not going to post here anymore. To just drop off is scary and sad.

Wonder about HopeandGratitude too. She last posted in the summer I think. She was having progression and posted about that and then nothing.

Nicole, thanks for the update from Grannax. Sad to hear that she has decided to stop treatments.
I agree with Candy - a post to say goodbye would be good.

Many have stopped posting which is scary.

Thanks Nicole! Please let AlabamaDee know that we miss her terribly and hope she can join us again soon. Is she at least able to read the postings?

(cross posted with Mel's Living Room)

I had an interesting appointment with my MO about what my next treatment will be. I've recently flipped to triple negative. MO reviewed her two most likely recommendations (Xeloda and Taxol) and a clinical trial being done in my hospital system studying a notch protein in triple negative bc. She still wants to get the info from Foundation One before deciding on a next step. My contact info has been given to the clinical trial staff and I would need to qualify by being tested for this notch protein that's common with triple negative. That's about all I know about the trial other than it's been going for some time and accruing some positive results. I'm up for going further and finding out specifics and whether I qualify. Two weeks till next appointment and although I'm concerned about the new lesions, I could really use two weeks to recover from my hip/leg pain and my lack of appetite issue before starting a new treatment.

Edit: found the infohttps://clinicaltrials.gov/ct2/show/NCT04461600

Sorry to hear that, Nicole. I wasn’t sure what exactly neoadjuvant or adjuvant meant. I think neoadjuvant is before any other treatment, like to shrink tumor for surgery? I’ve had only Ibrance/Letrozole so far. Almost 3 years. My MO thought I’d be a long responder but I guess it wasn’t to be. I hope you have a great response to Trodelvy. If I remember right you’ve already had a good scan with it?

So I got my Pet report back Yesterday and surprisingly NED from three cycles of Ibrance and Fulvestrant. So happy! The only thing is, is that the pseudocirrhosis is progressing and I still have portal hypertension and ascites. We didn't really talk about that part except that my liver went from being enlarged to smaller, and that pseudocirrhosis looks like cirrhosis on imagine but not on labs. I have read only bad things about it and it's bringing me down even though i'm NED. But that's cause I was in failure in August/Sept and had the bleeds as well.

I know Husband's wife has it and I'm hoping he will chime in on If his wifes pseudocirrhosis eventually slowed down or is still progressing without loss of function as I know she's done quite well despite. Sigh.. Wish I could just take the good news and run with it instead of stressing about the other stuff.